beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia.

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Standard

beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia. / Marsal, Jan; Brakebusch, Cord; Bungartz, Gerd; Fässler, Reinhard; Agace, William W.

I: European Journal of Immunology, Bind 35, Nr. 6, 2005, s. 1805-11.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Marsal, J, Brakebusch, C, Bungartz, G, Fässler, R & Agace, WW 2005, 'beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia.', European Journal of Immunology, bind 35, nr. 6, s. 1805-11. https://doi.org/10.1002/eji.200425941

APA

Marsal, J., Brakebusch, C., Bungartz, G., Fässler, R., & Agace, W. W. (2005). beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia. European Journal of Immunology, 35(6), 1805-11. https://doi.org/10.1002/eji.200425941

Vancouver

Marsal J, Brakebusch C, Bungartz G, Fässler R, Agace WW. beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia. European Journal of Immunology. 2005;35(6):1805-11. https://doi.org/10.1002/eji.200425941

Author

Marsal, Jan ; Brakebusch, Cord ; Bungartz, Gerd ; Fässler, Reinhard ; Agace, William W. / beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia. I: European Journal of Immunology. 2005 ; Bind 35, Nr. 6. s. 1805-11.

Bibtex

@article{82fa0390589411dd8d9f000ea68e967b,
title = "beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia.",
abstract = "beta(1) integrins are thought to play a central role in maintaining lymphocytes within mucosal epithelia via their interactions with extracellular matrix proteins and subepithelial cellular components within and underlying the basement membrane. In the current study type a (CD8alphabetaTCRalphabeta) and type b (CD8alphaalphaTCRgammadelta and CD8alphaalphaTCRalphabeta) intraepithelial lymphocyte (IEL) subsets within the mouse small intestine were found to express functional beta(1) integrin and the beta(1) integrin alpha chain partners alpha(1), alpha(2), and alpha(4). Using inducible beta(1) integrin-knockout bone marrow-chimeric mice we demonstrate that IEL expression of alpha(1) and alpha(2) but not alpha(4) is dependent on expression of the beta(1) chain. Importantly, deletion of the beta(1) chain in IEL did not alter the number or composition of lymphocytes within the intestinal epithelium. Thus, while IEL express functional beta(1) integrins, these are not required to maintain lymphocytes within intestinal epithelia. This result is discussed in the light of conventional views of intestinal lymphocyte homing and localization.",
author = "Jan Marsal and Cord Brakebusch and Gerd Bungartz and Reinhard F{\"a}ssler and Agace, {William W}",
note = "Keywords: Animals; Antigens, CD29; Integrin alpha1beta1; Intestinal Mucosa; Lymphocytes; Mice; Mice, Inbred C57BL",
year = "2005",
doi = "10.1002/eji.200425941",
language = "English",
volume = "35",
pages = "1805--11",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "6",

}

RIS

TY - JOUR

T1 - beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia.

AU - Marsal, Jan

AU - Brakebusch, Cord

AU - Bungartz, Gerd

AU - Fässler, Reinhard

AU - Agace, William W

N1 - Keywords: Animals; Antigens, CD29; Integrin alpha1beta1; Intestinal Mucosa; Lymphocytes; Mice; Mice, Inbred C57BL

PY - 2005

Y1 - 2005

N2 - beta(1) integrins are thought to play a central role in maintaining lymphocytes within mucosal epithelia via their interactions with extracellular matrix proteins and subepithelial cellular components within and underlying the basement membrane. In the current study type a (CD8alphabetaTCRalphabeta) and type b (CD8alphaalphaTCRgammadelta and CD8alphaalphaTCRalphabeta) intraepithelial lymphocyte (IEL) subsets within the mouse small intestine were found to express functional beta(1) integrin and the beta(1) integrin alpha chain partners alpha(1), alpha(2), and alpha(4). Using inducible beta(1) integrin-knockout bone marrow-chimeric mice we demonstrate that IEL expression of alpha(1) and alpha(2) but not alpha(4) is dependent on expression of the beta(1) chain. Importantly, deletion of the beta(1) chain in IEL did not alter the number or composition of lymphocytes within the intestinal epithelium. Thus, while IEL express functional beta(1) integrins, these are not required to maintain lymphocytes within intestinal epithelia. This result is discussed in the light of conventional views of intestinal lymphocyte homing and localization.

AB - beta(1) integrins are thought to play a central role in maintaining lymphocytes within mucosal epithelia via their interactions with extracellular matrix proteins and subepithelial cellular components within and underlying the basement membrane. In the current study type a (CD8alphabetaTCRalphabeta) and type b (CD8alphaalphaTCRgammadelta and CD8alphaalphaTCRalphabeta) intraepithelial lymphocyte (IEL) subsets within the mouse small intestine were found to express functional beta(1) integrin and the beta(1) integrin alpha chain partners alpha(1), alpha(2), and alpha(4). Using inducible beta(1) integrin-knockout bone marrow-chimeric mice we demonstrate that IEL expression of alpha(1) and alpha(2) but not alpha(4) is dependent on expression of the beta(1) chain. Importantly, deletion of the beta(1) chain in IEL did not alter the number or composition of lymphocytes within the intestinal epithelium. Thus, while IEL express functional beta(1) integrins, these are not required to maintain lymphocytes within intestinal epithelia. This result is discussed in the light of conventional views of intestinal lymphocyte homing and localization.

U2 - 10.1002/eji.200425941

DO - 10.1002/eji.200425941

M3 - Journal article

C2 - 15884052

VL - 35

SP - 1805

EP - 1811

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 6

ER -

ID: 5141188