TY - JOUR

T1 - Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood

T2 - A Proof-of-Concept Federated Analysis in 18 Birth Cohorts

AU - Cadman, Tim

AU - Elhakeem, Ahmed

AU - Vinther, Johan Lerbech

AU - Avraam, Demetris

AU - Carrasco, Paula

AU - Calas, Lucinda

AU - Cardol, Marloes

AU - Charles, Marie-Aline

AU - Corpeleijn, Eva

AU - Crozier, Sarah

AU - de Castro, Montserrat

AU - Estarlich, Marisa

AU - Fernandes, Amanda

AU - Fossatti, Serena

AU - Gruszfeld, Dariusz

AU - Guerlich, Kathrin

AU - Grote, Veit

AU - Haakma, Sido

AU - Harris, Jennifer R

AU - Heude, Barbara

AU - Huang, Rae-Chi

AU - Ibarluzea, Jesús

AU - Inskip, Hazel

AU - Jaddoe, Vincent

AU - Koletzko, Berthold

AU - Lioret, Sandrine

AU - Luque, Veronica

AU - Manios, Yannis

AU - Moirano, Giovenale

AU - Moschonis, George

AU - Nader, Johanna

AU - Nieuwenhuijsen, Mark

AU - Andersen, Anne-Marie Nybo

AU - McEachen, Rosie

AU - de Moira, Angela Pinot

AU - Popovic, Maja

AU - Roumeliotaki, Theano

AU - Salika, Theodosia

AU - Santa Marina, Loreto

AU - Santos, Susana

AU - Serbert, Sylvain

AU - Tzorovili, Evangelia

AU - Vafeiadi, Marina

AU - Verduci, Elvira

AU - Vrijheid, Martine

AU - Vrijkotte, T G M

AU - Welten, Marieke

AU - Wright, John

AU - Yang, Tiffany C

AU - Zugna, Daniela

AU - Lawlor, Deborah

N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.

PY - 2024

Y1 - 2024

N2 - International sharing of cohort data for research is important and challenging. We explored the feasibility of multicohort federated analyses by examining associations between 3 pregnancy exposures (maternal education, exposure to green vegetation, and gestational diabetes) and offspring body mass index (BMI) from infancy to age 17 years. We used data from 18 cohorts (n = 206,180 mother-child pairs) from the EU Child Cohort Network and derived BMI at ages 0-1, 2-3, 4-7, 8-13, and 14-17 years. Associations were estimated using linear regression via 1-stage individual participant data meta-analysis using DataSHIELD. Associations between lower maternal education and higher child BMI emerged from age 4 and increased with age (difference in BMI z score comparing low with high education, at age 2-3 years = 0.03 (95% confidence interval (CI): 0.00, 0.05), at 4-7 years = 0.16 (95% CI: 0.14, 0.17), and at 8-13 years = 0.24 (95% CI: 0.22, 0.26)). Gestational diabetes was positively associated with BMI from age 8 years (BMI z score difference = 0.18, 95% CI: 0.12, 0.25) but not at younger ages; however, associations attenuated towards the null when restricted to cohorts that measured gestational diabetes via universal screening. Exposure to green vegetation was weakly associated with higher BMI up to age 1 year but not at older ages. Opportunities of cross-cohort federated analyses are discussed.

AB - International sharing of cohort data for research is important and challenging. We explored the feasibility of multicohort federated analyses by examining associations between 3 pregnancy exposures (maternal education, exposure to green vegetation, and gestational diabetes) and offspring body mass index (BMI) from infancy to age 17 years. We used data from 18 cohorts (n = 206,180 mother-child pairs) from the EU Child Cohort Network and derived BMI at ages 0-1, 2-3, 4-7, 8-13, and 14-17 years. Associations were estimated using linear regression via 1-stage individual participant data meta-analysis using DataSHIELD. Associations between lower maternal education and higher child BMI emerged from age 4 and increased with age (difference in BMI z score comparing low with high education, at age 2-3 years = 0.03 (95% confidence interval (CI): 0.00, 0.05), at 4-7 years = 0.16 (95% CI: 0.14, 0.17), and at 8-13 years = 0.24 (95% CI: 0.22, 0.26)). Gestational diabetes was positively associated with BMI from age 8 years (BMI z score difference = 0.18, 95% CI: 0.12, 0.25) but not at younger ages; however, associations attenuated towards the null when restricted to cohorts that measured gestational diabetes via universal screening. Exposure to green vegetation was weakly associated with higher BMI up to age 1 year but not at older ages. Opportunities of cross-cohort federated analyses are discussed.

KW - Humans

KW - Diabetes, Gestational/epidemiology

KW - Female

KW - Pregnancy

KW - Body Mass Index

KW - Adolescent

KW - Infant

KW - Child, Preschool

KW - Child

KW - Educational Status

KW - Male

KW - Prenatal Exposure Delayed Effects/epidemiology

KW - Birth Cohort

KW - Infant, Newborn

KW - Adult

KW - Proof of Concept Study

KW - Parks, Recreational/statistics & numerical data

U2 - 10.1093/aje/kwad206

DO - 10.1093/aje/kwad206

M3 - Journal article

C2 - 37856700

VL - 193

SP - 753

EP - 763

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 5

ER -