Arterial and venous concentrations of phenobarbital, phenytoin, clonazepam, and diazepam after rapid intravenous injections
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Arterial and venous concentrations of phenobarbital, phenytoin, clonazepam, and diazepam after rapid intravenous injections. / Bøjholm, S; Paulson, O B; Flachs, Helga.
I: Clinical Pharmacology and Therapeutics, Bind 32, Nr. 4, 10.1982, s. 478-83.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Arterial and venous concentrations of phenobarbital, phenytoin, clonazepam, and diazepam after rapid intravenous injections
AU - Bøjholm, S
AU - Paulson, O B
AU - Flachs, Helga
PY - 1982/10
Y1 - 1982/10
N2 - Arterial and venous concentrations of phenobarbital, phenytoin, clonazepam, and diazepam were followed for 12 hr after a rapid intravenous injection. Initial blood samples were collected at intervals of only 5 sec. The arterial curves were initially much higher and steeper than the venous. For all four drugs the arterial curves could be described as triexponential functions. The initial part of the arterial curves were used in determining the initial supply to and uptake rate in the organs.
AB - Arterial and venous concentrations of phenobarbital, phenytoin, clonazepam, and diazepam were followed for 12 hr after a rapid intravenous injection. Initial blood samples were collected at intervals of only 5 sec. The arterial curves were initially much higher and steeper than the venous. For all four drugs the arterial curves could be described as triexponential functions. The initial part of the arterial curves were used in determining the initial supply to and uptake rate in the organs.
KW - Anticonvulsants/blood
KW - Arteries
KW - Clonazepam/blood
KW - Diazepam/blood
KW - Humans
KW - Injections, Intravenous
KW - Phenobarbital/blood
KW - Phenytoin/blood
KW - Time Factors
KW - Veins
U2 - 10.1038/clpt.1982.191
DO - 10.1038/clpt.1982.191
M3 - Journal article
C2 - 7116763
VL - 32
SP - 478
EP - 483
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
SN - 0009-9236
IS - 4
ER -
ID: 279620832