Aortic dimensions in women with previous pre-eclampsia

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Standard

Aortic dimensions in women with previous pre-eclampsia. / Møller, Emma L.R.; Hauge, Maria G.; Pham, Michael H.C.; Damm, Peter; Kofoed, Klaus F.; Fuchs, Andreas; Kühl, Jørgen T.; Sigvardsen, Per E.; Ersbøll, Anne S.; Johansen, Marianne; Nordestgaard, Børge G.; Køber, Lars V.; Gustafsson, Finn; Linde, Jesper J.

I: Journal of Cardiovascular Computed Tomography, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Møller, ELR, Hauge, MG, Pham, MHC, Damm, P, Kofoed, KF, Fuchs, A, Kühl, JT, Sigvardsen, PE, Ersbøll, AS, Johansen, M, Nordestgaard, BG, Køber, LV, Gustafsson, F & Linde, JJ 2024, 'Aortic dimensions in women with previous pre-eclampsia', Journal of Cardiovascular Computed Tomography. https://doi.org/10.1016/j.jcct.2024.06.001

APA

Møller, E. L. R., Hauge, M. G., Pham, M. H. C., Damm, P., Kofoed, K. F., Fuchs, A., Kühl, J. T., Sigvardsen, P. E., Ersbøll, A. S., Johansen, M., Nordestgaard, B. G., Køber, L. V., Gustafsson, F., & Linde, J. J. (Accepteret/In press). Aortic dimensions in women with previous pre-eclampsia. Journal of Cardiovascular Computed Tomography. https://doi.org/10.1016/j.jcct.2024.06.001

Vancouver

Møller ELR, Hauge MG, Pham MHC, Damm P, Kofoed KF, Fuchs A o.a. Aortic dimensions in women with previous pre-eclampsia. Journal of Cardiovascular Computed Tomography. 2024. https://doi.org/10.1016/j.jcct.2024.06.001

Author

Møller, Emma L.R. ; Hauge, Maria G. ; Pham, Michael H.C. ; Damm, Peter ; Kofoed, Klaus F. ; Fuchs, Andreas ; Kühl, Jørgen T. ; Sigvardsen, Per E. ; Ersbøll, Anne S. ; Johansen, Marianne ; Nordestgaard, Børge G. ; Køber, Lars V. ; Gustafsson, Finn ; Linde, Jesper J. / Aortic dimensions in women with previous pre-eclampsia. I: Journal of Cardiovascular Computed Tomography. 2024.

Bibtex

@article{7906b72e1ae94375903d19a03c2e7e29,

title = "Aortic dimensions in women with previous pre-eclampsia",

abstract = "Background: Pre-eclampsia is a pregnancy related disorder associated with hypertension and vascular inflammation, factors that are also involved in the pathological pathway of aortic dilatation and aneurysm development. It is, however, unknown if younger women with previous pre-eclampsia have increased aortic dimensions. We tested the hypothesis that previous pre-eclampsia is associated with increased aortic dimensions in younger women. Methods: The study was a cross-sectional cohort study of women with previous pre-eclampsia, aged 40–55, from the PRECIOUS population matched by age and parity with women from the general population. Using contrast-enhanced CT, aortic diameters were measured in the aortic root, ascending aorta, descending aorta, at the level of the diaphragm, suprarenal aorta, and infrarenal aorta. Results: 1355 women (684 with previous pre-eclampsia and 671 from the general population), with a mean (standard deviation) age of 46.9 (4.4) were included. The pre-eclampsia group had larger mean (standard deviation) aortic diameters (mm) in all measured segments from the ascending to the infrarenal aorta (ascending: 33.4 (4.0) vs. 31.4 (3.7), descending: 23.9 (2.1) vs. 23.3 (2.0), diaphragm: 20.8 (1.8) vs. 20.4 (1.8), suprarenal: 22.9 (1.9) vs. 22.0 (2.0), infrarenal: 19.3 (1.6) vs. 18.6 (1.7), p < 0.001 for all, also after adjustment for age, height, parity, menopause, dyslipidemia, smoking and chronic hypertension. Guideline-defined ascending aortic aneurysms were found in 8 vs 2 women (p = 0.12). Conclusions: Women with previous pre-eclampsia have larger aortic dimensions compared with women from the general population. Pre-eclampsia was found to be an independent risk factor associated with a larger aortic diameter.",

keywords = "Aortic aneurysms, Aortic dimensions, Cardiac risk assessment in women, Pre-eclampsia",

author = "M{\o}ller, {Emma L.R.} and Hauge, {Maria G.} and Pham, {Michael H.C.} and Peter Damm and Kofoed, {Klaus F.} and Andreas Fuchs and K{\"u}hl, {J{\o}rgen T.} and Sigvardsen, {Per E.} and Ersb{\o}ll, {Anne S.} and Marianne Johansen and Nordestgaard, {B{\o}rge G.} and K{\o}ber, {Lars V.} and Finn Gustafsson and Linde, {Jesper J.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

doi = "10.1016/j.jcct.2024.06.001",

language = "English",

journal = "Journal of Cardiovascular Computed Tomography",

issn = "1934-5925",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Aortic dimensions in women with previous pre-eclampsia

AU - Møller, Emma L.R.

AU - Hauge, Maria G.

AU - Pham, Michael H.C.

AU - Damm, Peter

AU - Kofoed, Klaus F.

AU - Fuchs, Andreas

AU - Kühl, Jørgen T.

AU - Sigvardsen, Per E.

AU - Ersbøll, Anne S.

AU - Johansen, Marianne

AU - Nordestgaard, Børge G.

AU - Køber, Lars V.

AU - Gustafsson, Finn

AU - Linde, Jesper J.

PY - 2024

Y1 - 2024

N2 - Background: Pre-eclampsia is a pregnancy related disorder associated with hypertension and vascular inflammation, factors that are also involved in the pathological pathway of aortic dilatation and aneurysm development. It is, however, unknown if younger women with previous pre-eclampsia have increased aortic dimensions. We tested the hypothesis that previous pre-eclampsia is associated with increased aortic dimensions in younger women. Methods: The study was a cross-sectional cohort study of women with previous pre-eclampsia, aged 40–55, from the PRECIOUS population matched by age and parity with women from the general population. Using contrast-enhanced CT, aortic diameters were measured in the aortic root, ascending aorta, descending aorta, at the level of the diaphragm, suprarenal aorta, and infrarenal aorta. Results: 1355 women (684 with previous pre-eclampsia and 671 from the general population), with a mean (standard deviation) age of 46.9 (4.4) were included. The pre-eclampsia group had larger mean (standard deviation) aortic diameters (mm) in all measured segments from the ascending to the infrarenal aorta (ascending: 33.4 (4.0) vs. 31.4 (3.7), descending: 23.9 (2.1) vs. 23.3 (2.0), diaphragm: 20.8 (1.8) vs. 20.4 (1.8), suprarenal: 22.9 (1.9) vs. 22.0 (2.0), infrarenal: 19.3 (1.6) vs. 18.6 (1.7), p < 0.001 for all, also after adjustment for age, height, parity, menopause, dyslipidemia, smoking and chronic hypertension. Guideline-defined ascending aortic aneurysms were found in 8 vs 2 women (p = 0.12). Conclusions: Women with previous pre-eclampsia have larger aortic dimensions compared with women from the general population. Pre-eclampsia was found to be an independent risk factor associated with a larger aortic diameter.

AB - Background: Pre-eclampsia is a pregnancy related disorder associated with hypertension and vascular inflammation, factors that are also involved in the pathological pathway of aortic dilatation and aneurysm development. It is, however, unknown if younger women with previous pre-eclampsia have increased aortic dimensions. We tested the hypothesis that previous pre-eclampsia is associated with increased aortic dimensions in younger women. Methods: The study was a cross-sectional cohort study of women with previous pre-eclampsia, aged 40–55, from the PRECIOUS population matched by age and parity with women from the general population. Using contrast-enhanced CT, aortic diameters were measured in the aortic root, ascending aorta, descending aorta, at the level of the diaphragm, suprarenal aorta, and infrarenal aorta. Results: 1355 women (684 with previous pre-eclampsia and 671 from the general population), with a mean (standard deviation) age of 46.9 (4.4) were included. The pre-eclampsia group had larger mean (standard deviation) aortic diameters (mm) in all measured segments from the ascending to the infrarenal aorta (ascending: 33.4 (4.0) vs. 31.4 (3.7), descending: 23.9 (2.1) vs. 23.3 (2.0), diaphragm: 20.8 (1.8) vs. 20.4 (1.8), suprarenal: 22.9 (1.9) vs. 22.0 (2.0), infrarenal: 19.3 (1.6) vs. 18.6 (1.7), p < 0.001 for all, also after adjustment for age, height, parity, menopause, dyslipidemia, smoking and chronic hypertension. Guideline-defined ascending aortic aneurysms were found in 8 vs 2 women (p = 0.12). Conclusions: Women with previous pre-eclampsia have larger aortic dimensions compared with women from the general population. Pre-eclampsia was found to be an independent risk factor associated with a larger aortic diameter.

KW - Aortic aneurysms

KW - Aortic dimensions

KW - Cardiac risk assessment in women

KW - Pre-eclampsia

U2 - 10.1016/j.jcct.2024.06.001

DO - 10.1016/j.jcct.2024.06.001

M3 - Journal article

C2 - 38866633

AN - SCOPUS:85195633586

JO - Journal of Cardiovascular Computed Tomography

JF - Journal of Cardiovascular Computed Tomography

SN - 1934-5925

ER -

ID: 395134141

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