Angiotensin-converting enzyme: an indicator of bleomycin-induced pulmonary toxicity in humans?

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Standard

Angiotensin-converting enzyme: an indicator of bleomycin-induced pulmonary toxicity in humans? / Sørensen, Peter G; Rømer, F K; Cortes, Dina.

I: European journal of cancer & clinical oncology, Bind 20, Nr. 11, 01.11.1984, s. 1405-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Sørensen, PG, Rømer, FK & Cortes, D 1984, 'Angiotensin-converting enzyme: an indicator of bleomycin-induced pulmonary toxicity in humans?', European journal of cancer & clinical oncology, bind 20, nr. 11, s. 1405-8.

APA

Sørensen, P. G., Rømer, F. K., & Cortes, D. (1984). Angiotensin-converting enzyme: an indicator of bleomycin-induced pulmonary toxicity in humans? European journal of cancer & clinical oncology, 20(11), 1405-8.

Vancouver

Sørensen PG, Rømer FK, Cortes D. Angiotensin-converting enzyme: an indicator of bleomycin-induced pulmonary toxicity in humans? European journal of cancer & clinical oncology. 1984 nov. 1;20(11):1405-8.

Author

Sørensen, Peter G ; Rømer, F K ; Cortes, Dina. / Angiotensin-converting enzyme: an indicator of bleomycin-induced pulmonary toxicity in humans?. I: European journal of cancer & clinical oncology. 1984 ; Bind 20, Nr. 11. s. 1405-8.

Bibtex

@article{27270995789f43e8809ec98f2220fbde,
title = "Angiotensin-converting enzyme: an indicator of bleomycin-induced pulmonary toxicity in humans?",
abstract = "In order to evaluate bleomycin-associated lung damage in humans, lung function parameters and serum levels of the endothelial-bound angiotensin-converting enzyme (ACE) were determined by serial measurements in 11 patients who were treated for testicular cancer. None developed clinical or radiological evidence of pulmonary damage. While the static and dynamic lung function parameters were unchanged, carbon monoxide diffusion capacity (DLCO) decreased significantly (P less than 0.01) during a total of 126 days of pulsed regimen, indicating damage to the alveolar-endothelial membrane. S-ACE was unchanged within each treatment course but increased significantly (P less than 0.05) from the initial value to the last treatment course. Two months after cessation of treatment S-ACE returned to pretreatment values. Although the changes were modest they might mirror treatment-associated endothelial damage.",
keywords = "Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, Bleomycin, Cisplatin, Humans, Lung Diseases, Male, Peptidyl-Dipeptidase A, Respiratory Function Tests, Teratoma, Testicular Neoplasms, Time Factors, Vinblastine",
author = "S{\o}rensen, {Peter G} and R{\o}mer, {F K} and Dina Cortes",
year = "1984",
month = nov,
day = "1",
language = "English",
volume = "20",
pages = "1405--8",
journal = "European Journal of Cancer and Clinical Oncology",
issn = "0277-5379",
publisher = "Pergamon Press",
number = "11",

}

RIS

TY - JOUR

T1 - Angiotensin-converting enzyme: an indicator of bleomycin-induced pulmonary toxicity in humans?

AU - Sørensen, Peter G

AU - Rømer, F K

AU - Cortes, Dina

PY - 1984/11/1

Y1 - 1984/11/1

N2 - In order to evaluate bleomycin-associated lung damage in humans, lung function parameters and serum levels of the endothelial-bound angiotensin-converting enzyme (ACE) were determined by serial measurements in 11 patients who were treated for testicular cancer. None developed clinical or radiological evidence of pulmonary damage. While the static and dynamic lung function parameters were unchanged, carbon monoxide diffusion capacity (DLCO) decreased significantly (P less than 0.01) during a total of 126 days of pulsed regimen, indicating damage to the alveolar-endothelial membrane. S-ACE was unchanged within each treatment course but increased significantly (P less than 0.05) from the initial value to the last treatment course. Two months after cessation of treatment S-ACE returned to pretreatment values. Although the changes were modest they might mirror treatment-associated endothelial damage.

AB - In order to evaluate bleomycin-associated lung damage in humans, lung function parameters and serum levels of the endothelial-bound angiotensin-converting enzyme (ACE) were determined by serial measurements in 11 patients who were treated for testicular cancer. None developed clinical or radiological evidence of pulmonary damage. While the static and dynamic lung function parameters were unchanged, carbon monoxide diffusion capacity (DLCO) decreased significantly (P less than 0.01) during a total of 126 days of pulsed regimen, indicating damage to the alveolar-endothelial membrane. S-ACE was unchanged within each treatment course but increased significantly (P less than 0.05) from the initial value to the last treatment course. Two months after cessation of treatment S-ACE returned to pretreatment values. Although the changes were modest they might mirror treatment-associated endothelial damage.

KW - Adolescent

KW - Adult

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Bleomycin

KW - Cisplatin

KW - Humans

KW - Lung Diseases

KW - Male

KW - Peptidyl-Dipeptidase A

KW - Respiratory Function Tests

KW - Teratoma

KW - Testicular Neoplasms

KW - Time Factors

KW - Vinblastine

M3 - Journal article

C2 - 6209143

VL - 20

SP - 1405

EP - 1408

JO - European Journal of Cancer and Clinical Oncology

JF - European Journal of Cancer and Clinical Oncology

SN - 0277-5379

IS - 11

ER -

ID: 34345618