Angiotensin converting enzyme inhibition and cerebral blood flow autoregulation in normotensive and hypertensive man
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Angiotensin converting enzyme inhibition and cerebral blood flow autoregulation in normotensive and hypertensive man. / Waldemar, G; Schmidt, J F; Andersen, A R; Vorstrup, S; Ibsen, H; Paulson, O B.
I: Journal of Hypertension, Bind 7, Nr. 3, 03.1989, s. 229-35.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Angiotensin converting enzyme inhibition and cerebral blood flow autoregulation in normotensive and hypertensive man
AU - Waldemar, G
AU - Schmidt, J F
AU - Andersen, A R
AU - Vorstrup, S
AU - Ibsen, H
AU - Paulson, O B
PY - 1989/3
Y1 - 1989/3
N2 - The acute effect on the lower limit of cerebral blood flow (CBF) autoregulation of an angiotensin converting enzyme (ACE) inhibitor, captopril, was studied in normotensive volunteers and in hypertensive patients. Baseline CBF was measured using xenon-133 inhalation tomography, and changes in CBF were measured using the arterio-venous oxygen difference method. Cerebral blood flow autoregulation was studied in two separate normotensive groups, one group of 12 volunteers serving as a control, and one group of 12 volunteers studied after the administration of captopril 50 mg. In a group of seven hypertensive patients CBF autoregulation was studied before and 1 h after the administration of captopril 25 mg. In the normotensive volunteers the median lower limit of CBF autoregulation was 83 and 74 mmHg in the untreated and the captopril-treated group, respectively, with no significant difference between the two groups. In five of the hypertensive patients the lower limit of CBF autoregulation was lowered by captopril, in median by 22 mmHg. However, in two patients it was increased, by 3 and 13 mmHg, respectively. It is proposed that the shift in the lower limit of CBF autoregulation seen in some of our cases, and which has previously been documented in experimental studies, may be dependent on the activity of the sympathetic nervous system.
AB - The acute effect on the lower limit of cerebral blood flow (CBF) autoregulation of an angiotensin converting enzyme (ACE) inhibitor, captopril, was studied in normotensive volunteers and in hypertensive patients. Baseline CBF was measured using xenon-133 inhalation tomography, and changes in CBF were measured using the arterio-venous oxygen difference method. Cerebral blood flow autoregulation was studied in two separate normotensive groups, one group of 12 volunteers serving as a control, and one group of 12 volunteers studied after the administration of captopril 50 mg. In a group of seven hypertensive patients CBF autoregulation was studied before and 1 h after the administration of captopril 25 mg. In the normotensive volunteers the median lower limit of CBF autoregulation was 83 and 74 mmHg in the untreated and the captopril-treated group, respectively, with no significant difference between the two groups. In five of the hypertensive patients the lower limit of CBF autoregulation was lowered by captopril, in median by 22 mmHg. However, in two patients it was increased, by 3 and 13 mmHg, respectively. It is proposed that the shift in the lower limit of CBF autoregulation seen in some of our cases, and which has previously been documented in experimental studies, may be dependent on the activity of the sympathetic nervous system.
KW - Adult
KW - Angiotensin-Converting Enzyme Inhibitors/pharmacology
KW - Captopril/pharmacology
KW - Cerebrovascular Circulation/drug effects
KW - Female
KW - Homeostasis/drug effects
KW - Humans
KW - Hypertension/physiopathology
KW - Male
KW - Middle Aged
KW - Peptidyl-Dipeptidase A/physiology
M3 - Journal article
C2 - 2540235
VL - 7
SP - 229
EP - 235
JO - Journal of Hypertension, Supplement
JF - Journal of Hypertension, Supplement
SN - 0952-1178
IS - 3
ER -
ID: 275282046