TY - JOUR

T1 - An Uncommon Case of Pediatric Esthesioneuroblastoma Presenting as SIADH

T2 - 18F-FDG PET/CT in Staging and Post-Therapeutic Assessment

AU - Fosbøl, Marie Øbro

AU - Bilde, Anders

AU - Friborg, Jeppe

AU - von Benzon, Eric

AU - Kjær, Andreas

AU - von Buchwald, Christian

AU - Borgwardt, Lise

PY - 2018

Y1 - 2018

N2 - Esthesioneuroblastoma (ENB) is an uncommon neuroendocrine tumor originating from the olfactory neuroepithelium and accounts for 3-6% of all intranasal tumors [¹]. ENBs can be locally aggressive and cause invasion and destruction of surrounding structures. Histological grading and clinical stage at presentation are highly predictive of survival and especially presence of lymph node and distant metastases are determining prognostic factors [²,³,⁴,⁵]. Thus, reliable imaging is essential in these patients. Conventional imaging modalities for staging ENB are magnetic resonance imaging (MRI) and computed tomography (CT). However, fluorine-18 fluoro-2-deoxy-d-glucose positron emission tomography/CT (18F-FDG PET/CT) has been reported as a valuable adjunct and was found to upstage 36% of ENB patients compared to conventional imaging [6]. We present a case demonstrating the diagnostic work-up and follow-up with 18F-FDG PET/CT in a young patient with ENB with a highly atypical clinical presentation.

AB - Esthesioneuroblastoma (ENB) is an uncommon neuroendocrine tumor originating from the olfactory neuroepithelium and accounts for 3-6% of all intranasal tumors [¹]. ENBs can be locally aggressive and cause invasion and destruction of surrounding structures. Histological grading and clinical stage at presentation are highly predictive of survival and especially presence of lymph node and distant metastases are determining prognostic factors [²,³,⁴,⁵]. Thus, reliable imaging is essential in these patients. Conventional imaging modalities for staging ENB are magnetic resonance imaging (MRI) and computed tomography (CT). However, fluorine-18 fluoro-2-deoxy-d-glucose positron emission tomography/CT (18F-FDG PET/CT) has been reported as a valuable adjunct and was found to upstage 36% of ENB patients compared to conventional imaging [6]. We present a case demonstrating the diagnostic work-up and follow-up with 18F-FDG PET/CT in a young patient with ENB with a highly atypical clinical presentation.

U2 - 10.3390/diagnostics8010008

DO - 10.3390/diagnostics8010008

M3 - Journal article

C2 - 29342907

VL - 8

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 1

M1 - 8

ER -