TY - JOUR

T1 - An outbreak of suspected water-borne epidemic non-A non-B hepatitis in northern Botswana with a high prevalence of hepatitis B carriers and hepatitis delta markers among patients

AU - Byskov, Jens

AU - Wouters, J S

AU - Sathekge, T J

AU - Swanepoel, R

N1 - Transactions of the Royal Society of Trop Med and Hyg 1989;83:110-116.

PY - 1989

Y1 - 1989

N2 - From June to December 1985 273 cases of hepatitis and jaundice were diagnosed in Maun, northern Botswana. It was known before the outbreak that most adults were immune to hepatitis A virus, most had markers indicating past infection with hepatitis B virus (HBV), there was a mean prevalence of 13.6% (57/418) HBsAg carriers, and a proportion of people had antibodies to hepatitis delta virus (HDV). There was evidence that faecal contamination of water supplies preceded the outbreak; the epidemic curve suggested that there was a major common source of infection; the disease appeared to have affected 1-2% of the population; 90.3% (214/237) patients for whom information is available were aged 20 years or older; the disease was generally mild and affected pregnant women most severely. 49 patients were admitted to hospital and at least 4/273 died. There were prevalences of 47% (28/60) HBsAg and 69% (37/54) anti-HDV reactors among patients bled 1-43 d after the onset of illness. The main features of the outbreak conformed to published descriptions of water-borne epidemic non-A non-B hepatitis and it is postulated that the disease was most severe in patients with active HBV infection and in those with HDV superinfection, so that such patients were disproportionately represented amongst those seeking medical attention.

AB - From June to December 1985 273 cases of hepatitis and jaundice were diagnosed in Maun, northern Botswana. It was known before the outbreak that most adults were immune to hepatitis A virus, most had markers indicating past infection with hepatitis B virus (HBV), there was a mean prevalence of 13.6% (57/418) HBsAg carriers, and a proportion of people had antibodies to hepatitis delta virus (HDV). There was evidence that faecal contamination of water supplies preceded the outbreak; the epidemic curve suggested that there was a major common source of infection; the disease appeared to have affected 1-2% of the population; 90.3% (214/237) patients for whom information is available were aged 20 years or older; the disease was generally mild and affected pregnant women most severely. 49 patients were admitted to hospital and at least 4/273 died. There were prevalences of 47% (28/60) HBsAg and 69% (37/54) anti-HDV reactors among patients bled 1-43 d after the onset of illness. The main features of the outbreak conformed to published descriptions of water-borne epidemic non-A non-B hepatitis and it is postulated that the disease was most severe in patients with active HBV infection and in those with HDV superinfection, so that such patients were disproportionately represented amongst those seeking medical attention.

KW - Adolescent

KW - Adult

KW - Alanine Transaminase

KW - Aspartate Aminotransferases

KW - Bilirubin

KW - Botswana

KW - Disease Outbreaks

KW - Female

KW - Hepatitis Antibodies

KW - Hepatitis B

KW - Hepatitis B Antigens

KW - Hepatitis B Surface Antigens

KW - Hepatitis C

KW - Hepatitis D

KW - Hepatitis, Viral, Human

KW - Humans

KW - Male

KW - Water Microbiology

M3 - Journal article

C2 - 2513670

VL - 83

SP - 110

EP - 116

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 1

ER -