Acute beta-blockade changes the extracellular distribution of thyroid hormones
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Acute beta-blockade changes the extracellular distribution of thyroid hormones. / Kayser, L.; Perrild, H.; Petersen, P. H.; Skovsted, L.; Hansen, J. E.M.
I: Journal of Endocrinological Investigation: Official Journal of the Italian Scociety of Endocrinology, Bind 13, Nr. 4, 04.1990, s. 277-281.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Acute beta-blockade changes the extracellular distribution of thyroid hormones
AU - Kayser, L.
AU - Perrild, H.
AU - Petersen, P. H.
AU - Skovsted, L.
AU - Hansen, J. E.M.
PY - 1990/4
Y1 - 1990/4
N2 - The acute (within hours) changes in the concentrations of T4, T3, reverse-T3 (rT3) and T3 resin uptake test (T3RU) were studied in 31 hyperthyroid patients for 4 h after po treatment with either acebutolol, Oxprenolol, pindolol or timolol. In 21 of the patients, the changes were compared to changes in the serum concentrations of α2-macroglobulin (a macromoleculë) and two middle-sized molecules; thyroid hormone-binding globulin (TBG) and albumin in order to calculate the changes in extracellular distribution of the thyroid hormones and to distinguish between changes due to a changed metabolism and changes due to a changed distribution of the thyroid hormones. Acebutolol, Oxprenolol and timolol caused a decrease in serum T3 after 1/2 h, and acebutolol and Oxprenolol also a decrease in rT3 after 1/2-1 h, the changes reversed within 2 h. A concomitant decrease in serum albumin and TBG suggests a change in the extracellular distribution of middlesized molecules to which thyroid hormones are attached, as an explanation of the acute decrease (1 h) of the thyroid hormones. The small and insignificant change in α2-macroglobulin indicates that the changes are mainly extravascular, but the difference of α2-macroglobulin changes between the drugs (acebutolol/timolol vs pindolol/oxprenolol) could depend on the intrinsic sympathomimetic activity of the drugs.
AB - The acute (within hours) changes in the concentrations of T4, T3, reverse-T3 (rT3) and T3 resin uptake test (T3RU) were studied in 31 hyperthyroid patients for 4 h after po treatment with either acebutolol, Oxprenolol, pindolol or timolol. In 21 of the patients, the changes were compared to changes in the serum concentrations of α2-macroglobulin (a macromoleculë) and two middle-sized molecules; thyroid hormone-binding globulin (TBG) and albumin in order to calculate the changes in extracellular distribution of the thyroid hormones and to distinguish between changes due to a changed metabolism and changes due to a changed distribution of the thyroid hormones. Acebutolol, Oxprenolol and timolol caused a decrease in serum T3 after 1/2 h, and acebutolol and Oxprenolol also a decrease in rT3 after 1/2-1 h, the changes reversed within 2 h. A concomitant decrease in serum albumin and TBG suggests a change in the extracellular distribution of middlesized molecules to which thyroid hormones are attached, as an explanation of the acute decrease (1 h) of the thyroid hormones. The small and insignificant change in α2-macroglobulin indicates that the changes are mainly extravascular, but the difference of α2-macroglobulin changes between the drugs (acebutolol/timolol vs pindolol/oxprenolol) could depend on the intrinsic sympathomimetic activity of the drugs.
KW - acute changes
KW - albumin
KW - beta-adrenergic blockade
KW - Thyroid
KW - α -macroglobulin
UR - http://www.scopus.com/inward/record.url?scp=0025299612&partnerID=8YFLogxK
U2 - 10.1007/BF03349560
DO - 10.1007/BF03349560
M3 - Journal article
C2 - 1695234
AN - SCOPUS:0025299612
VL - 13
SP - 277
EP - 281
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 4
ER -
ID: 335355612