Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes

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Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes. / Maytham, Kaisar; Hagelqvist, Per G; Engberg, Susanne; Forman, Julie L; Pedersen-Bjergaard, Ulrik; Knop, Filip K; Vilsbøll, Tina; Andersen, Andreas.

I: Frontiers in Endocrinology, Bind 15, 1352829, 2024.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Maytham, K, Hagelqvist, PG, Engberg, S, Forman, JL, Pedersen-Bjergaard, U, Knop, FK, Vilsbøll, T & Andersen, A 2024, 'Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes', Frontiers in Endocrinology, bind 15, 1352829. https://doi.org/10.3389/fendo.2024.1352829

APA

Maytham, K., Hagelqvist, P. G., Engberg, S., Forman, J. L., Pedersen-Bjergaard, U., Knop, F. K., Vilsbøll, T., & Andersen, A. (2024). Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes. Frontiers in Endocrinology, 15, [1352829]. https://doi.org/10.3389/fendo.2024.1352829

Vancouver

Maytham K, Hagelqvist PG, Engberg S, Forman JL, Pedersen-Bjergaard U, Knop FK o.a. Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes. Frontiers in Endocrinology. 2024;15. 1352829. https://doi.org/10.3389/fendo.2024.1352829

Author

Maytham, Kaisar ; Hagelqvist, Per G ; Engberg, Susanne ; Forman, Julie L ; Pedersen-Bjergaard, Ulrik ; Knop, Filip K ; Vilsbøll, Tina ; Andersen, Andreas. / Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes. I: Frontiers in Endocrinology. 2024 ; Bind 15.

Bibtex

@article{9b1ccc20a0e547ea82563814b4bba1f7,
title = "Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes",
abstract = "BACKGROUND: Hypoglycemia is common in individuals with type 1 diabetes, especially during exercise. We investigated the accuracy of two different continuous glucose monitoring systems during exercise-related hypoglycemia in an experimental setting.MATERIALS AND METHODS: Fifteen individuals with type 1 diabetes participated in two separate euglycemic-hypoglycemic clamp days (Clamp-exercise and Clamp-rest) including five phases: 1) baseline euglycemia, 2) plasma glucose (PG) decline ± exercise, 3) 15-minute hypoglycemia ± exercise, 4) 45-minute hypoglycemia, and 5) recovery euglycemia. Interstitial PG levels were measured every five minutes, using Dexcom G6 (DG6) and FreeStyle Libre 1 (FSL1). Yellow Springs Instruments 2900 was used as PG reference method, enabling mean absolute relative difference (MARD) assessment for each phase and Clarke error grid analysis for each day.RESULTS: Exercise had a negative effect on FSL1 accuracy in phase 2 and 3 compared to rest (ΔMARD = +5.3 percentage points [(95% CI): 1.6, 9.1] and +13.5 percentage points [6.4, 20.5], respectively). In contrast, exercise had a positive effect on DG6 accuracy during phase 2 and 4 compared to rest (ΔMARD = -6.2 percentage points [-11.2, -1.2] and -8.4 percentage points [-12.4, -4.3], respectively). Clarke error grid analysis showed a decrease in clinically acceptable treatment decisions during Clamp-exercise for FSL1 while a contrary increase was observed for DG6.CONCLUSION: Physical exercise had clinically relevant impact on the accuracy of the investigated continuous glucose monitoring systems and their ability to accurately detect hypoglycemia.",
keywords = "Humans, Diabetes Mellitus, Type 1/blood, Hypoglycemia/blood, Male, Exercise, Female, Adult, Blood Glucose/analysis, Blood Glucose Self-Monitoring/methods, Glucose Clamp Technique, Young Adult, Middle Aged, Continuous Glucose Monitoring",
author = "Kaisar Maytham and Hagelqvist, {Per G} and Susanne Engberg and Forman, {Julie L} and Ulrik Pedersen-Bjergaard and Knop, {Filip K} and Tina Vilsb{\o}ll and Andreas Andersen",
note = "Copyright {\textcopyright} 2024 Maytham, Hagelqvist, Engberg, Forman, Pedersen-Bjergaard, Knop, Vilsb{\o}ll and Andersen.",
year = "2024",
doi = "10.3389/fendo.2024.1352829",
language = "English",
volume = "15",
journal = "Frontiers in Endocrinology",
issn = "1664-2392",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes

AU - Maytham, Kaisar

AU - Hagelqvist, Per G

AU - Engberg, Susanne

AU - Forman, Julie L

AU - Pedersen-Bjergaard, Ulrik

AU - Knop, Filip K

AU - Vilsbøll, Tina

AU - Andersen, Andreas

N1 - Copyright © 2024 Maytham, Hagelqvist, Engberg, Forman, Pedersen-Bjergaard, Knop, Vilsbøll and Andersen.

PY - 2024

Y1 - 2024

N2 - BACKGROUND: Hypoglycemia is common in individuals with type 1 diabetes, especially during exercise. We investigated the accuracy of two different continuous glucose monitoring systems during exercise-related hypoglycemia in an experimental setting.MATERIALS AND METHODS: Fifteen individuals with type 1 diabetes participated in two separate euglycemic-hypoglycemic clamp days (Clamp-exercise and Clamp-rest) including five phases: 1) baseline euglycemia, 2) plasma glucose (PG) decline ± exercise, 3) 15-minute hypoglycemia ± exercise, 4) 45-minute hypoglycemia, and 5) recovery euglycemia. Interstitial PG levels were measured every five minutes, using Dexcom G6 (DG6) and FreeStyle Libre 1 (FSL1). Yellow Springs Instruments 2900 was used as PG reference method, enabling mean absolute relative difference (MARD) assessment for each phase and Clarke error grid analysis for each day.RESULTS: Exercise had a negative effect on FSL1 accuracy in phase 2 and 3 compared to rest (ΔMARD = +5.3 percentage points [(95% CI): 1.6, 9.1] and +13.5 percentage points [6.4, 20.5], respectively). In contrast, exercise had a positive effect on DG6 accuracy during phase 2 and 4 compared to rest (ΔMARD = -6.2 percentage points [-11.2, -1.2] and -8.4 percentage points [-12.4, -4.3], respectively). Clarke error grid analysis showed a decrease in clinically acceptable treatment decisions during Clamp-exercise for FSL1 while a contrary increase was observed for DG6.CONCLUSION: Physical exercise had clinically relevant impact on the accuracy of the investigated continuous glucose monitoring systems and their ability to accurately detect hypoglycemia.

AB - BACKGROUND: Hypoglycemia is common in individuals with type 1 diabetes, especially during exercise. We investigated the accuracy of two different continuous glucose monitoring systems during exercise-related hypoglycemia in an experimental setting.MATERIALS AND METHODS: Fifteen individuals with type 1 diabetes participated in two separate euglycemic-hypoglycemic clamp days (Clamp-exercise and Clamp-rest) including five phases: 1) baseline euglycemia, 2) plasma glucose (PG) decline ± exercise, 3) 15-minute hypoglycemia ± exercise, 4) 45-minute hypoglycemia, and 5) recovery euglycemia. Interstitial PG levels were measured every five minutes, using Dexcom G6 (DG6) and FreeStyle Libre 1 (FSL1). Yellow Springs Instruments 2900 was used as PG reference method, enabling mean absolute relative difference (MARD) assessment for each phase and Clarke error grid analysis for each day.RESULTS: Exercise had a negative effect on FSL1 accuracy in phase 2 and 3 compared to rest (ΔMARD = +5.3 percentage points [(95% CI): 1.6, 9.1] and +13.5 percentage points [6.4, 20.5], respectively). In contrast, exercise had a positive effect on DG6 accuracy during phase 2 and 4 compared to rest (ΔMARD = -6.2 percentage points [-11.2, -1.2] and -8.4 percentage points [-12.4, -4.3], respectively). Clarke error grid analysis showed a decrease in clinically acceptable treatment decisions during Clamp-exercise for FSL1 while a contrary increase was observed for DG6.CONCLUSION: Physical exercise had clinically relevant impact on the accuracy of the investigated continuous glucose monitoring systems and their ability to accurately detect hypoglycemia.

KW - Humans

KW - Diabetes Mellitus, Type 1/blood

KW - Hypoglycemia/blood

KW - Male

KW - Exercise

KW - Female

KW - Adult

KW - Blood Glucose/analysis

KW - Blood Glucose Self-Monitoring/methods

KW - Glucose Clamp Technique

KW - Young Adult

KW - Middle Aged

KW - Continuous Glucose Monitoring

U2 - 10.3389/fendo.2024.1352829

DO - 10.3389/fendo.2024.1352829

M3 - Journal article

C2 - 38686202

VL - 15

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

M1 - 1352829

ER -

ID: 391045728