a-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg

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a-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg. / Keller, David M; Sander, Mikael; Stallknecht, Bente Merete; Crandall, Craig G.

I: Journal of Physiology, Bind 588, Nr. Pt 19, 01.10.2010, s. 3799-808.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Keller, DM, Sander, M, Stallknecht, BM & Crandall, CG 2010, 'a-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg', Journal of Physiology, bind 588, nr. Pt 19, s. 3799-808. https://doi.org/10.1113/jphysiol.2010.194506

APA

Keller, D. M., Sander, M., Stallknecht, B. M., & Crandall, C. G. (2010). a-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg. Journal of Physiology, 588(Pt 19), 3799-808. https://doi.org/10.1113/jphysiol.2010.194506

Vancouver

Keller DM, Sander M, Stallknecht BM, Crandall CG. a-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg. Journal of Physiology. 2010 okt. 1;588(Pt 19):3799-808. https://doi.org/10.1113/jphysiol.2010.194506

Author

Keller, David M ; Sander, Mikael ; Stallknecht, Bente Merete ; Crandall, Craig G. / a-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg. I: Journal of Physiology. 2010 ; Bind 588, Nr. Pt 19. s. 3799-808.

Bibtex

@article{77cb8984fad6468996d13a861f8e210e,
title = "a-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg",
abstract = "This study tested the hypothesis that passive leg heating attenuates a-adrenergic vasoconstriction within that limb. Femoral blood flow (FBF, femoral artery ultrasound Doppler) and femoral vascular conductance (FVC, FBF/mean arterial blood pressure), as well as calf muscle blood flow (CalfBF, ¹³³xenon) and calf vascular conductance (CalfVC) were measured during intra-arterial infusion of an a1-adrenoreceptor agonist, phenylephrine (PE, 0.025 to 0.8 µg kg¿1 min¿1) and an a2-adrenoreceptor agonist, BHT-933 (1.0 to 10 µg kg¿1 min¿1) during normothermia and passive leg heating (water-perfused pant leg). Passive leg heating (~46¿C water temperature) increased FVC from 4.5 ± 0.5 to 11.9 ± 1.3 ml min¿1 mmHg¿1 (P <0.001). Interestingly, CalfBF (1.8±0.2 vs. 2.8±0.3mlmin¿1 (100 g)¿1) and CalfVC (2.0±0.3 vs. 3.9±0.5mlmin¿1 (100 g)¿1 mmHg¿1 ×100) were also increased by this perturbation (P ",
keywords = "Adrenergic alpha-1 Receptor Agonists, Adrenergic alpha-2 Receptor Antagonists, Adrenergic alpha-Agonists, Adult, Azepines, Blood Pressure, Body Temperature, Dose-Response Relationship, Drug, Hot Temperature, Humans, Leg, Male, Muscle, Skeletal, Phenylephrine, Receptors, Adrenergic, alpha, Regional Blood Flow, Ultrasonography, Doppler, Vasoconstriction, Xenon Radioisotopes, Young Adult",
author = "Keller, {David M} and Mikael Sander and Stallknecht, {Bente Merete} and Crandall, {Craig G}",
year = "2010",
month = oct,
day = "1",
doi = "10.1113/jphysiol.2010.194506",
language = "English",
volume = "588",
pages = "3799--808",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "Pt 19",

}

RIS

TY - JOUR

T1 - a-Adrenergic vasoconstrictor responsiveness is preserved in the heated human leg

AU - Keller, David M

AU - Sander, Mikael

AU - Stallknecht, Bente Merete

AU - Crandall, Craig G

PY - 2010/10/1

Y1 - 2010/10/1

N2 - This study tested the hypothesis that passive leg heating attenuates a-adrenergic vasoconstriction within that limb. Femoral blood flow (FBF, femoral artery ultrasound Doppler) and femoral vascular conductance (FVC, FBF/mean arterial blood pressure), as well as calf muscle blood flow (CalfBF, ¹³³xenon) and calf vascular conductance (CalfVC) were measured during intra-arterial infusion of an a1-adrenoreceptor agonist, phenylephrine (PE, 0.025 to 0.8 µg kg¿1 min¿1) and an a2-adrenoreceptor agonist, BHT-933 (1.0 to 10 µg kg¿1 min¿1) during normothermia and passive leg heating (water-perfused pant leg). Passive leg heating (~46¿C water temperature) increased FVC from 4.5 ± 0.5 to 11.9 ± 1.3 ml min¿1 mmHg¿1 (P <0.001). Interestingly, CalfBF (1.8±0.2 vs. 2.8±0.3mlmin¿1 (100 g)¿1) and CalfVC (2.0±0.3 vs. 3.9±0.5mlmin¿1 (100 g)¿1 mmHg¿1 ×100) were also increased by this perturbation (P

AB - This study tested the hypothesis that passive leg heating attenuates a-adrenergic vasoconstriction within that limb. Femoral blood flow (FBF, femoral artery ultrasound Doppler) and femoral vascular conductance (FVC, FBF/mean arterial blood pressure), as well as calf muscle blood flow (CalfBF, ¹³³xenon) and calf vascular conductance (CalfVC) were measured during intra-arterial infusion of an a1-adrenoreceptor agonist, phenylephrine (PE, 0.025 to 0.8 µg kg¿1 min¿1) and an a2-adrenoreceptor agonist, BHT-933 (1.0 to 10 µg kg¿1 min¿1) during normothermia and passive leg heating (water-perfused pant leg). Passive leg heating (~46¿C water temperature) increased FVC from 4.5 ± 0.5 to 11.9 ± 1.3 ml min¿1 mmHg¿1 (P <0.001). Interestingly, CalfBF (1.8±0.2 vs. 2.8±0.3mlmin¿1 (100 g)¿1) and CalfVC (2.0±0.3 vs. 3.9±0.5mlmin¿1 (100 g)¿1 mmHg¿1 ×100) were also increased by this perturbation (P

KW - Adrenergic alpha-1 Receptor Agonists

KW - Adrenergic alpha-2 Receptor Antagonists

KW - Adrenergic alpha-Agonists

KW - Adult

KW - Azepines

KW - Blood Pressure

KW - Body Temperature

KW - Dose-Response Relationship, Drug

KW - Hot Temperature

KW - Humans

KW - Leg

KW - Male

KW - Muscle, Skeletal

KW - Phenylephrine

KW - Receptors, Adrenergic, alpha

KW - Regional Blood Flow

KW - Ultrasonography, Doppler

KW - Vasoconstriction

KW - Xenon Radioisotopes

KW - Young Adult

U2 - 10.1113/jphysiol.2010.194506

DO - 10.1113/jphysiol.2010.194506

M3 - Journal article

C2 - 20693291

VL - 588

SP - 3799

EP - 3808

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - Pt 19

ER -

ID: 33941195