A long-term follow-up study of hyposensitization with immunoblotting

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Standard

A long-term follow-up study of hyposensitization with immunoblotting. / Jarolim, E; Poulsen, L K; Stadler, B M; Mosbech, H; Oesterballe, O; Kraft, D; Weeke, B.

I: The Journal of allergy and clinical immunology, Bind 85, Nr. 6, 06.1990, s. 996-1004.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jarolim, E, Poulsen, LK, Stadler, BM, Mosbech, H, Oesterballe, O, Kraft, D & Weeke, B 1990, 'A long-term follow-up study of hyposensitization with immunoblotting', The Journal of allergy and clinical immunology, bind 85, nr. 6, s. 996-1004.

APA

Jarolim, E., Poulsen, L. K., Stadler, B. M., Mosbech, H., Oesterballe, O., Kraft, D., & Weeke, B. (1990). A long-term follow-up study of hyposensitization with immunoblotting. The Journal of allergy and clinical immunology, 85(6), 996-1004.

Vancouver

Jarolim E, Poulsen LK, Stadler BM, Mosbech H, Oesterballe O, Kraft D o.a. A long-term follow-up study of hyposensitization with immunoblotting. The Journal of allergy and clinical immunology. 1990 jun.;85(6):996-1004.

Author

Jarolim, E ; Poulsen, L K ; Stadler, B M ; Mosbech, H ; Oesterballe, O ; Kraft, D ; Weeke, B. / A long-term follow-up study of hyposensitization with immunoblotting. I: The Journal of allergy and clinical immunology. 1990 ; Bind 85, Nr. 6. s. 996-1004.

Bibtex

@article{698312b8030e43eb8060ae137b976752,
title = "A long-term follow-up study of hyposensitization with immunoblotting",
abstract = "The formation of specific IgE, IgG1, and IgG4 antibodies was investigated by immunoblotting during hyposensitization with timothy grass-pollen extract and 6 years later, Until the end of immunotherapy, specific IgG antibody levels increased. Also simultaneously, the number of allergenic components detected by IgG increased. However, this IgG response was similar in responding and nonresponding patients; thus, it did not correlate with the clinical outcome of the therapy. More allergenic compounds were also detected by IgE on immunoblots, but again without correlation to success of therapy. Six years after immunotherapy, the therapeutic effect was still present, although by now the observed immunoglobulin-binding patterns were similar to patterns observed in the same patients' sera collected before the initiation of hyposensitization. Thus, changes of antibody-binding patterns in immunoblot do not relate to the success or failure of immunotherapy.",
keywords = "Allergens, Desensitization, Immunologic, Follow-Up Studies, Humans, Hypersensitivity, Immunoblotting, Immunoglobulin E, Immunoglobulin G, Immunotherapy, Protein Binding, Time Factors, Journal Article",
author = "E Jarolim and Poulsen, {L K} and Stadler, {B M} and H Mosbech and O Oesterballe and D Kraft and B Weeke",
year = "1990",
month = jun,
language = "English",
volume = "85",
pages = "996--1004",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - A long-term follow-up study of hyposensitization with immunoblotting

AU - Jarolim, E

AU - Poulsen, L K

AU - Stadler, B M

AU - Mosbech, H

AU - Oesterballe, O

AU - Kraft, D

AU - Weeke, B

PY - 1990/6

Y1 - 1990/6

N2 - The formation of specific IgE, IgG1, and IgG4 antibodies was investigated by immunoblotting during hyposensitization with timothy grass-pollen extract and 6 years later, Until the end of immunotherapy, specific IgG antibody levels increased. Also simultaneously, the number of allergenic components detected by IgG increased. However, this IgG response was similar in responding and nonresponding patients; thus, it did not correlate with the clinical outcome of the therapy. More allergenic compounds were also detected by IgE on immunoblots, but again without correlation to success of therapy. Six years after immunotherapy, the therapeutic effect was still present, although by now the observed immunoglobulin-binding patterns were similar to patterns observed in the same patients' sera collected before the initiation of hyposensitization. Thus, changes of antibody-binding patterns in immunoblot do not relate to the success or failure of immunotherapy.

AB - The formation of specific IgE, IgG1, and IgG4 antibodies was investigated by immunoblotting during hyposensitization with timothy grass-pollen extract and 6 years later, Until the end of immunotherapy, specific IgG antibody levels increased. Also simultaneously, the number of allergenic components detected by IgG increased. However, this IgG response was similar in responding and nonresponding patients; thus, it did not correlate with the clinical outcome of the therapy. More allergenic compounds were also detected by IgE on immunoblots, but again without correlation to success of therapy. Six years after immunotherapy, the therapeutic effect was still present, although by now the observed immunoglobulin-binding patterns were similar to patterns observed in the same patients' sera collected before the initiation of hyposensitization. Thus, changes of antibody-binding patterns in immunoblot do not relate to the success or failure of immunotherapy.

KW - Allergens

KW - Desensitization, Immunologic

KW - Follow-Up Studies

KW - Humans

KW - Hypersensitivity

KW - Immunoblotting

KW - Immunoglobulin E

KW - Immunoglobulin G

KW - Immunotherapy

KW - Protein Binding

KW - Time Factors

KW - Journal Article

M3 - Journal article

C2 - 2355159

VL - 85

SP - 996

EP - 1004

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 6

ER -

ID: 169715232