A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening

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A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening. / van den Berg, Rosa; Kooijman, Sander; Noordam, Raymond; Ramkisoensing, Ashna; Abreu-Vieira, Gustavo; Tambyrajah, Lauren L.; Dijk, Wieneke; Ruppert, Philip; Mol, Isabel M.; Kramar, Barbara; Caputo, Rosanna; Puig, Laura Sardón; de Ruiter, Evelien M.; Kroon, Jan; Hoekstra, Menno; van der Sluis, Ronald J.; Meijer, Onno C.; Willems van Dijk, Ko; van Kerkhof, Linda W.M.; Christodoulides, Constantinos; Karpe, Fredrik; Gerhart-Hines, Zachary; Kersten, Sander; Meijer, Johanna H.; Coomans, Claudia P.; van Heemst, Diana; Biermasz, Nienke R.; Rensen, Patrick C.N.

I: Cell Reports, Bind 22, Nr. 13, 2018, s. 3521-3533.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

van den Berg, R, Kooijman, S, Noordam, R, Ramkisoensing, A, Abreu-Vieira, G, Tambyrajah, LL, Dijk, W, Ruppert, P, Mol, IM, Kramar, B, Caputo, R, Puig, LS, de Ruiter, EM, Kroon, J, Hoekstra, M, van der Sluis, RJ, Meijer, OC, Willems van Dijk, K, van Kerkhof, LWM, Christodoulides, C, Karpe, F, Gerhart-Hines, Z, Kersten, S, Meijer, JH, Coomans, CP, van Heemst, D, Biermasz, NR & Rensen, PCN 2018, 'A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening', Cell Reports, bind 22, nr. 13, s. 3521-3533. https://doi.org/10.1016/j.celrep.2018.03.004

APA

van den Berg, R., Kooijman, S., Noordam, R., Ramkisoensing, A., Abreu-Vieira, G., Tambyrajah, L. L., Dijk, W., Ruppert, P., Mol, I. M., Kramar, B., Caputo, R., Puig, L. S., de Ruiter, E. M., Kroon, J., Hoekstra, M., van der Sluis, R. J., Meijer, O. C., Willems van Dijk, K., van Kerkhof, L. W. M., ... Rensen, P. C. N. (2018). A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening. Cell Reports, 22(13), 3521-3533. https://doi.org/10.1016/j.celrep.2018.03.004

Vancouver

van den Berg R, Kooijman S, Noordam R, Ramkisoensing A, Abreu-Vieira G, Tambyrajah LL o.a. A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening. Cell Reports. 2018;22(13):3521-3533. https://doi.org/10.1016/j.celrep.2018.03.004

Author

van den Berg, Rosa ; Kooijman, Sander ; Noordam, Raymond ; Ramkisoensing, Ashna ; Abreu-Vieira, Gustavo ; Tambyrajah, Lauren L. ; Dijk, Wieneke ; Ruppert, Philip ; Mol, Isabel M. ; Kramar, Barbara ; Caputo, Rosanna ; Puig, Laura Sardón ; de Ruiter, Evelien M. ; Kroon, Jan ; Hoekstra, Menno ; van der Sluis, Ronald J. ; Meijer, Onno C. ; Willems van Dijk, Ko ; van Kerkhof, Linda W.M. ; Christodoulides, Constantinos ; Karpe, Fredrik ; Gerhart-Hines, Zachary ; Kersten, Sander ; Meijer, Johanna H. ; Coomans, Claudia P. ; van Heemst, Diana ; Biermasz, Nienke R. ; Rensen, Patrick C.N. / A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening. I: Cell Reports. 2018 ; Bind 22, Nr. 13. s. 3521-3533.

Bibtex

@article{6702a51909644f128287ae52d1c538c1,
title = "A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening",
abstract = "Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity. van den Berg et al. show a strong circadian rhythm in fatty acid uptake by brown adipose tissue that peaks at wakening regardless of the light exposure period. Consequently, postprandial lipid handling by brown adipose tissue is highest at wakening, resulting in the lowest postprandial plasma lipid excursions.",
keywords = "angiopoietin-like 4, APOE3-Leiden.CETP mice, brown adipose tissue, circadian rhythm, diurnal rhythm, fatty acids, lipoprotein lipase, postprandial lipid response, triglycerides",
author = "{van den Berg}, Rosa and Sander Kooijman and Raymond Noordam and Ashna Ramkisoensing and Gustavo Abreu-Vieira and Tambyrajah, {Lauren L.} and Wieneke Dijk and Philip Ruppert and Mol, {Isabel M.} and Barbara Kramar and Rosanna Caputo and Puig, {Laura Sard{\'o}n} and {de Ruiter}, {Evelien M.} and Jan Kroon and Menno Hoekstra and {van der Sluis}, {Ronald J.} and Meijer, {Onno C.} and {Willems van Dijk}, Ko and {van Kerkhof}, {Linda W.M.} and Constantinos Christodoulides and Fredrik Karpe and Zachary Gerhart-Hines and Sander Kersten and Meijer, {Johanna H.} and Coomans, {Claudia P.} and {van Heemst}, Diana and Biermasz, {Nienke R.} and Rensen, {Patrick C.N.}",
year = "2018",
doi = "10.1016/j.celrep.2018.03.004",
language = "English",
volume = "22",
pages = "3521--3533",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "13",

}

RIS

TY - JOUR

T1 - A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening

AU - van den Berg, Rosa

AU - Kooijman, Sander

AU - Noordam, Raymond

AU - Ramkisoensing, Ashna

AU - Abreu-Vieira, Gustavo

AU - Tambyrajah, Lauren L.

AU - Dijk, Wieneke

AU - Ruppert, Philip

AU - Mol, Isabel M.

AU - Kramar, Barbara

AU - Caputo, Rosanna

AU - Puig, Laura Sardón

AU - de Ruiter, Evelien M.

AU - Kroon, Jan

AU - Hoekstra, Menno

AU - van der Sluis, Ronald J.

AU - Meijer, Onno C.

AU - Willems van Dijk, Ko

AU - van Kerkhof, Linda W.M.

AU - Christodoulides, Constantinos

AU - Karpe, Fredrik

AU - Gerhart-Hines, Zachary

AU - Kersten, Sander

AU - Meijer, Johanna H.

AU - Coomans, Claudia P.

AU - van Heemst, Diana

AU - Biermasz, Nienke R.

AU - Rensen, Patrick C.N.

PY - 2018

Y1 - 2018

N2 - Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity. van den Berg et al. show a strong circadian rhythm in fatty acid uptake by brown adipose tissue that peaks at wakening regardless of the light exposure period. Consequently, postprandial lipid handling by brown adipose tissue is highest at wakening, resulting in the lowest postprandial plasma lipid excursions.

AB - Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity. van den Berg et al. show a strong circadian rhythm in fatty acid uptake by brown adipose tissue that peaks at wakening regardless of the light exposure period. Consequently, postprandial lipid handling by brown adipose tissue is highest at wakening, resulting in the lowest postprandial plasma lipid excursions.

KW - angiopoietin-like 4

KW - APOE3-Leiden.CETP mice

KW - brown adipose tissue

KW - circadian rhythm

KW - diurnal rhythm

KW - fatty acids

KW - lipoprotein lipase

KW - postprandial lipid response

KW - triglycerides

U2 - 10.1016/j.celrep.2018.03.004

DO - 10.1016/j.celrep.2018.03.004

M3 - Journal article

C2 - 29590620

AN - SCOPUS:85044505277

VL - 22

SP - 3521

EP - 3533

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 13

ER -

ID: 195255536