9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The preparation of 6-(9-acridinylamino)hexanoic acid DHBT ester and N alpha-Fmoc-N epsilon-(4-nitrophenylsulfonyl)-L-lysine DHBT ester and their application in solid phase peptide synthesis are described. The 9-acridinylamino ligand was shown to confer high DNA affinity, probably by intercalation, to the resulting peptides. The 4-nitrophenylsulfamido ligand furthermore resulted in "photonuclease" activity of some of the modified peptides.
Originalsprog | Engelsk |
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Tidsskrift | International Journal of Peptide and Protein Research |
Vol/bind | 32 |
Udgave nummer | 5 |
Sider (fra-til) | 331-343 |
Antal sider | 13 |
ISSN | 0367-8377 |
Status | Udgivet - nov. 1988 |
ID: 203631170