4-Aminosalicylic acid, in contrast to 5-aminosalicylic acid, has no effect on arachidonic acid metabolism in human neutrophils, or on the free radical 1,1-diphenyl-2-picrylhydrazyl

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Standard

4-Aminosalicylic acid, in contrast to 5-aminosalicylic acid, has no effect on arachidonic acid metabolism in human neutrophils, or on the free radical 1,1-diphenyl-2-picrylhydrazyl. / Nielsen, O H; Ahnfelt-Rønne, I.

I: Pharmacology & Toxicology, Bind 62, Nr. 4, 04.1988, s. 223-6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nielsen, OH & Ahnfelt-Rønne, I 1988, '4-Aminosalicylic acid, in contrast to 5-aminosalicylic acid, has no effect on arachidonic acid metabolism in human neutrophils, or on the free radical 1,1-diphenyl-2-picrylhydrazyl', Pharmacology & Toxicology, bind 62, nr. 4, s. 223-6.

APA

Nielsen, O. H., & Ahnfelt-Rønne, I. (1988). 4-Aminosalicylic acid, in contrast to 5-aminosalicylic acid, has no effect on arachidonic acid metabolism in human neutrophils, or on the free radical 1,1-diphenyl-2-picrylhydrazyl. Pharmacology & Toxicology, 62(4), 223-6.

Vancouver

Nielsen OH, Ahnfelt-Rønne I. 4-Aminosalicylic acid, in contrast to 5-aminosalicylic acid, has no effect on arachidonic acid metabolism in human neutrophils, or on the free radical 1,1-diphenyl-2-picrylhydrazyl. Pharmacology & Toxicology. 1988 apr.;62(4):223-6.

Author

Nielsen, O H ; Ahnfelt-Rønne, I. / 4-Aminosalicylic acid, in contrast to 5-aminosalicylic acid, has no effect on arachidonic acid metabolism in human neutrophils, or on the free radical 1,1-diphenyl-2-picrylhydrazyl. I: Pharmacology & Toxicology. 1988 ; Bind 62, Nr. 4. s. 223-6.

Bibtex

@article{fdd2223ea6914a62ad74a45549b9dfa3,
title = "4-Aminosalicylic acid, in contrast to 5-aminosalicylic acid, has no effect on arachidonic acid metabolism in human neutrophils, or on the free radical 1,1-diphenyl-2-picrylhydrazyl",
abstract = "5-Aminosalicylic acid seems to be the active moiety of sulfasalazine in the treatment of chronic inflammatory bowel disease. Even if the precise mode of action is obscure, it is assumed that two of the main mechanisms are inhibitory effects on the lipoxygenation of arachidonic acid and interaction with free radicals. As 4-aminosalicylic acid has been claimed to be beneficial in the topical treatment of ulcerative colitis, it was tested whether this drug possesses any influence on the 5-lipoxygenase activity in human neutrophils in vitro or whether it acts as a radical scavenger. The change of the amino residue from carbon-5 to carbon-4 abolished the effect in the two systems tested. The reported clinical observations on 4-aminosalicylic acid in the treatment of chronic inflammatory bowel disease remain to be confirmed and cannot be explained by interference with arachidonic acid metabolism or free oxygen radicals.",
keywords = "Aminosalicylic Acid/pharmacology, Aminosalicylic Acids/pharmacology, Arachidonic Acid, Arachidonic Acids/metabolism, Biphenyl Compounds, Free Radicals, Humans, Hydrazines/metabolism, Mesalamine, Neutrophils/drug effects, Picrates",
author = "Nielsen, {O H} and I Ahnfelt-R{\o}nne",
year = "1988",
month = apr,
language = "English",
volume = "62",
pages = "223--6",
journal = "Pharmacology and Toxicology",
issn = "0901-9928",
publisher = "Munksgaard ",
number = "4",

}

RIS

TY - JOUR

T1 - 4-Aminosalicylic acid, in contrast to 5-aminosalicylic acid, has no effect on arachidonic acid metabolism in human neutrophils, or on the free radical 1,1-diphenyl-2-picrylhydrazyl

AU - Nielsen, O H

AU - Ahnfelt-Rønne, I

PY - 1988/4

Y1 - 1988/4

N2 - 5-Aminosalicylic acid seems to be the active moiety of sulfasalazine in the treatment of chronic inflammatory bowel disease. Even if the precise mode of action is obscure, it is assumed that two of the main mechanisms are inhibitory effects on the lipoxygenation of arachidonic acid and interaction with free radicals. As 4-aminosalicylic acid has been claimed to be beneficial in the topical treatment of ulcerative colitis, it was tested whether this drug possesses any influence on the 5-lipoxygenase activity in human neutrophils in vitro or whether it acts as a radical scavenger. The change of the amino residue from carbon-5 to carbon-4 abolished the effect in the two systems tested. The reported clinical observations on 4-aminosalicylic acid in the treatment of chronic inflammatory bowel disease remain to be confirmed and cannot be explained by interference with arachidonic acid metabolism or free oxygen radicals.

AB - 5-Aminosalicylic acid seems to be the active moiety of sulfasalazine in the treatment of chronic inflammatory bowel disease. Even if the precise mode of action is obscure, it is assumed that two of the main mechanisms are inhibitory effects on the lipoxygenation of arachidonic acid and interaction with free radicals. As 4-aminosalicylic acid has been claimed to be beneficial in the topical treatment of ulcerative colitis, it was tested whether this drug possesses any influence on the 5-lipoxygenase activity in human neutrophils in vitro or whether it acts as a radical scavenger. The change of the amino residue from carbon-5 to carbon-4 abolished the effect in the two systems tested. The reported clinical observations on 4-aminosalicylic acid in the treatment of chronic inflammatory bowel disease remain to be confirmed and cannot be explained by interference with arachidonic acid metabolism or free oxygen radicals.

KW - Aminosalicylic Acid/pharmacology

KW - Aminosalicylic Acids/pharmacology

KW - Arachidonic Acid

KW - Arachidonic Acids/metabolism

KW - Biphenyl Compounds

KW - Free Radicals

KW - Humans

KW - Hydrazines/metabolism

KW - Mesalamine

KW - Neutrophils/drug effects

KW - Picrates

M3 - Journal article

C2 - 3133649

VL - 62

SP - 223

EP - 226

JO - Pharmacology and Toxicology

JF - Pharmacology and Toxicology

SN - 0901-9928

IS - 4

ER -

ID: 218729251