β2-Adrenergic receptor polymorphisms, asthma and COPD: two large population-based studies

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Standard

β2-Adrenergic receptor polymorphisms, asthma and COPD: two large population-based studies. / Thomsen, M; Nordestgaard, B G; Sethi, A A; Tybjærg-Hansen, Anne; Dahl, Morten.

I: European Respiratory Journal, Bind 39, Nr. 3, 2012, s. 558-66.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Thomsen, M, Nordestgaard, BG, Sethi, AA, Tybjærg-Hansen, A & Dahl, M 2012, 'β2-Adrenergic receptor polymorphisms, asthma and COPD: two large population-based studies', European Respiratory Journal, bind 39, nr. 3, s. 558-66. https://doi.org/10.1183/09031936.00023511

APA

Thomsen, M., Nordestgaard, B. G., Sethi, A. A., Tybjærg-Hansen, A., & Dahl, M. (2012). β2-Adrenergic receptor polymorphisms, asthma and COPD: two large population-based studies. European Respiratory Journal, 39(3), 558-66. https://doi.org/10.1183/09031936.00023511

Vancouver

Thomsen M, Nordestgaard BG, Sethi AA, Tybjærg-Hansen A, Dahl M. β2-Adrenergic receptor polymorphisms, asthma and COPD: two large population-based studies. European Respiratory Journal. 2012;39(3):558-66. https://doi.org/10.1183/09031936.00023511

Author

Thomsen, M ; Nordestgaard, B G ; Sethi, A A ; Tybjærg-Hansen, Anne ; Dahl, Morten. / β2-Adrenergic receptor polymorphisms, asthma and COPD: two large population-based studies. I: European Respiratory Journal. 2012 ; Bind 39, Nr. 3. s. 558-66.

Bibtex

@article{574794b4b5ad45adb6fd545970b5dc5a,
title = "β2-Adrenergic receptor polymorphisms, asthma and COPD: two large population-based studies",
abstract = "The {\ss}2-adrenergic receptor (ADRB2) is an important regulator of airway smooth muscle tone. We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile,Gly16Arg,Gln27Glu) are associated with lung function, asthma or chronic obstructive pulmonary disease (COPD).We first genotyped 8,971 individuals from the Copenhagen City Heart Study for all three polymorphisms. To validate our findings we genotyped an additional 53,777 individuals from the Copenhagen General Population Study for the Thr164Ile polymorphism.We identified 60,910 Thr164Ile noncarriers, 1,822 heterozygotes and 16 homozygotes. In the Copenhagen City Heart Study the Thr164Ile genotype associated with reduced FEV1%predicted (trend:p=0.01) and FEV1/FVC (p=0.001): Thr164Ile heterozygotes had 3% and 2% reduced FEV1%predicted and FEV1/FVC, respectively, compared with noncarriers. The odds ratio for COPD in Thr164Ile heterozygotes was 1.46 (95%CI:1.05-2.02). In the Copenhagen General Population Study the Thr164 genotype associated with reduced FEV1%predicted (p=0.04) and FEV1/FVC (p",
author = "M Thomsen and Nordestgaard, {B G} and Sethi, {A A} and Anne Tybj{\ae}rg-Hansen and Morten Dahl",
year = "2012",
doi = "10.1183/09031936.00023511",
language = "English",
volume = "39",
pages = "558--66",
journal = "The European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "3",

}

RIS

TY - JOUR

T1 - β2-Adrenergic receptor polymorphisms, asthma and COPD: two large population-based studies

AU - Thomsen, M

AU - Nordestgaard, B G

AU - Sethi, A A

AU - Tybjærg-Hansen, Anne

AU - Dahl, Morten

PY - 2012

Y1 - 2012

N2 - The ß2-adrenergic receptor (ADRB2) is an important regulator of airway smooth muscle tone. We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile,Gly16Arg,Gln27Glu) are associated with lung function, asthma or chronic obstructive pulmonary disease (COPD).We first genotyped 8,971 individuals from the Copenhagen City Heart Study for all three polymorphisms. To validate our findings we genotyped an additional 53,777 individuals from the Copenhagen General Population Study for the Thr164Ile polymorphism.We identified 60,910 Thr164Ile noncarriers, 1,822 heterozygotes and 16 homozygotes. In the Copenhagen City Heart Study the Thr164Ile genotype associated with reduced FEV1%predicted (trend:p=0.01) and FEV1/FVC (p=0.001): Thr164Ile heterozygotes had 3% and 2% reduced FEV1%predicted and FEV1/FVC, respectively, compared with noncarriers. The odds ratio for COPD in Thr164Ile heterozygotes was 1.46 (95%CI:1.05-2.02). In the Copenhagen General Population Study the Thr164 genotype associated with reduced FEV1%predicted (p=0.04) and FEV1/FVC (p

AB - The ß2-adrenergic receptor (ADRB2) is an important regulator of airway smooth muscle tone. We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile,Gly16Arg,Gln27Glu) are associated with lung function, asthma or chronic obstructive pulmonary disease (COPD).We first genotyped 8,971 individuals from the Copenhagen City Heart Study for all three polymorphisms. To validate our findings we genotyped an additional 53,777 individuals from the Copenhagen General Population Study for the Thr164Ile polymorphism.We identified 60,910 Thr164Ile noncarriers, 1,822 heterozygotes and 16 homozygotes. In the Copenhagen City Heart Study the Thr164Ile genotype associated with reduced FEV1%predicted (trend:p=0.01) and FEV1/FVC (p=0.001): Thr164Ile heterozygotes had 3% and 2% reduced FEV1%predicted and FEV1/FVC, respectively, compared with noncarriers. The odds ratio for COPD in Thr164Ile heterozygotes was 1.46 (95%CI:1.05-2.02). In the Copenhagen General Population Study the Thr164 genotype associated with reduced FEV1%predicted (p=0.04) and FEV1/FVC (p

U2 - 10.1183/09031936.00023511

DO - 10.1183/09031936.00023511

M3 - Journal article

C2 - 22075484

VL - 39

SP - 558

EP - 566

JO - The European Respiratory Journal

JF - The European Respiratory Journal

SN - 0903-1936

IS - 3

ER -

ID: 40184599