1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry: A review of its recent applications in drug design
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry : A review of its recent applications in drug design. / Bolchi, Cristiano; Bavo, Francesco; Appiani, Rebecca; Roda, Gabriella; Pallavicini, Marco.
I: European Journal of Medicinal Chemistry, Bind 200, 112419, 15.08.2020.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - 1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry
T2 - A review of its recent applications in drug design
AU - Bolchi, Cristiano
AU - Bavo, Francesco
AU - Appiani, Rebecca
AU - Roda, Gabriella
AU - Pallavicini, Marco
PY - 2020/8/15
Y1 - 2020/8/15
N2 - 1,4-Benzodioxane has long been a versatile template widely employed to design molecules endowed with diverse bioactivities. Its use spans the last decades of medicinal chemistry until today concerning many strategies of drug discovery, not excluding the most advanced ones. Here, more than fifty benzodioxane-related lead compounds, selected from recent literature, are presented showing the different approaches with which they have been developed. Agonists and antagonists at neuronal nicotinic, α1 adrenergic and serotoninergic receptor subtypes and antitumor and antibacterial agents form the most representative classes, but a variety of other biological targets are addressed by benzodioxane-containing compounds.
AB - 1,4-Benzodioxane has long been a versatile template widely employed to design molecules endowed with diverse bioactivities. Its use spans the last decades of medicinal chemistry until today concerning many strategies of drug discovery, not excluding the most advanced ones. Here, more than fifty benzodioxane-related lead compounds, selected from recent literature, are presented showing the different approaches with which they have been developed. Agonists and antagonists at neuronal nicotinic, α1 adrenergic and serotoninergic receptor subtypes and antitumor and antibacterial agents form the most representative classes, but a variety of other biological targets are addressed by benzodioxane-containing compounds.
KW - 1,4-Benzodioxane
KW - 5-HT
KW - alpha1-AR
KW - Antibacterial
KW - Anticancer
KW - nAChR
U2 - 10.1016/j.ejmech.2020.112419
DO - 10.1016/j.ejmech.2020.112419
M3 - Review
C2 - 32502862
AN - SCOPUS:85085663167
VL - 200
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
SN - 0223-5234
M1 - 112419
ER -
ID: 259878678