γδ T cells in homeostasis and host defence of epithelial barrier tissues

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

γδ T cells in homeostasis and host defence of epithelial barrier tissues. / Nielsen, Morten M.; Witherden, Deborah A.; Havran, Wendy L.

I: Nature Reviews. Microbiology, Bind 17, Nr. 12, 12.2017, s. 733-745.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Nielsen, MM, Witherden, DA & Havran, WL 2017, 'γδ T cells in homeostasis and host defence of epithelial barrier tissues', Nature Reviews. Microbiology, bind 17, nr. 12, s. 733-745. https://doi.org/10.1038/nri.2017.101

APA

Nielsen, M. M., Witherden, D. A., & Havran, W. L. (2017). γδ T cells in homeostasis and host defence of epithelial barrier tissues. Nature Reviews. Microbiology, 17(12), 733-745. https://doi.org/10.1038/nri.2017.101

Vancouver

Nielsen MM, Witherden DA, Havran WL. γδ T cells in homeostasis and host defence of epithelial barrier tissues. Nature Reviews. Microbiology. 2017 dec.;17(12):733-745. https://doi.org/10.1038/nri.2017.101

Author

Nielsen, Morten M. ; Witherden, Deborah A. ; Havran, Wendy L. / γδ T cells in homeostasis and host defence of epithelial barrier tissues. I: Nature Reviews. Microbiology. 2017 ; Bind 17, Nr. 12. s. 733-745.

Bibtex

@article{984fccb088c14f0f9d688c231f60c3df,
title = "γδ T cells in homeostasis and host defence of epithelial barrier tissues",
abstract = "Epithelial surfaces line the body and provide a crucial interface between the body and the external environment. Tissue-resident epithelial γδ T cells represent a major T cell population in the epithelial tissues and are ideally positioned to carry out barrier surveillance and aid in tissue homeostasis and repair. In this Review, we focus on the intraepithelial γδ T cell compartment of the two largest epithelial tissues in the body — namely, the epidermis and the intestine — and provide a comprehensive overview of the crucial contributions of intraepithelial γδ T cells to tissue integrity and repair, host homeostasis and protection in the context of the symbiotic relationship with the microbiome and during pathogen clearance. Finally, we describe epithelium-specific butyrophilin-like molecules and briefly review their emerging role in selectively shaping and regulating epidermal and intestinal γδ T cell repertoires.",
author = "Nielsen, {Morten M.} and Witherden, {Deborah A.} and Havran, {Wendy L.}",
year = "2017",
month = dec,
doi = "10.1038/nri.2017.101",
language = "English",
volume = "17",
pages = "733--745",
journal = "Nature Reviews. Microbiology",
issn = "1740-1526",
publisher = "nature publishing group",
number = "12",

}

RIS

TY - JOUR

T1 - γδ T cells in homeostasis and host defence of epithelial barrier tissues

AU - Nielsen, Morten M.

AU - Witherden, Deborah A.

AU - Havran, Wendy L.

PY - 2017/12

Y1 - 2017/12

N2 - Epithelial surfaces line the body and provide a crucial interface between the body and the external environment. Tissue-resident epithelial γδ T cells represent a major T cell population in the epithelial tissues and are ideally positioned to carry out barrier surveillance and aid in tissue homeostasis and repair. In this Review, we focus on the intraepithelial γδ T cell compartment of the two largest epithelial tissues in the body — namely, the epidermis and the intestine — and provide a comprehensive overview of the crucial contributions of intraepithelial γδ T cells to tissue integrity and repair, host homeostasis and protection in the context of the symbiotic relationship with the microbiome and during pathogen clearance. Finally, we describe epithelium-specific butyrophilin-like molecules and briefly review their emerging role in selectively shaping and regulating epidermal and intestinal γδ T cell repertoires.

AB - Epithelial surfaces line the body and provide a crucial interface between the body and the external environment. Tissue-resident epithelial γδ T cells represent a major T cell population in the epithelial tissues and are ideally positioned to carry out barrier surveillance and aid in tissue homeostasis and repair. In this Review, we focus on the intraepithelial γδ T cell compartment of the two largest epithelial tissues in the body — namely, the epidermis and the intestine — and provide a comprehensive overview of the crucial contributions of intraepithelial γδ T cells to tissue integrity and repair, host homeostasis and protection in the context of the symbiotic relationship with the microbiome and during pathogen clearance. Finally, we describe epithelium-specific butyrophilin-like molecules and briefly review their emerging role in selectively shaping and regulating epidermal and intestinal γδ T cell repertoires.

U2 - 10.1038/nri.2017.101

DO - 10.1038/nri.2017.101

M3 - Review

C2 - 28920588

VL - 17

SP - 733

EP - 745

JO - Nature Reviews. Microbiology

JF - Nature Reviews. Microbiology

SN - 1740-1526

IS - 12

ER -

ID: 186505782