GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors. / Ørskov, Cathrine; Hartmann, Bolette; Poulsen, Steen Seier; Thulesen, Jesper; Hare, Kristine Juul; Holst, Jens Juul.

In: Regulatory Peptides, Vol. 124, No. 1-3, 2005, p. 105-12.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ørskov, C, Hartmann, B, Poulsen, SS, Thulesen, J, Hare, KJ & Holst, JJ 2005, 'GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.', Regulatory Peptides, vol. 124, no. 1-3, pp. 105-12. https://doi.org/10.1016/j.regpep.2004.07.009

APA

Ørskov, C., Hartmann, B., Poulsen, S. S., Thulesen, J., Hare, K. J., & Holst, J. J. (2005). GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors. Regulatory Peptides, 124(1-3), 105-12. https://doi.org/10.1016/j.regpep.2004.07.009

Vancouver

Ørskov C, Hartmann B, Poulsen SS, Thulesen J, Hare KJ, Holst JJ. GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors. Regulatory Peptides. 2005;124(1-3):105-12. https://doi.org/10.1016/j.regpep.2004.07.009

Author

Ørskov, Cathrine ; Hartmann, Bolette ; Poulsen, Steen Seier ; Thulesen, Jesper ; Hare, Kristine Juul ; Holst, Jens Juul. / GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors. In: Regulatory Peptides. 2005 ; Vol. 124, No. 1-3. pp. 105-12.

Bibtex

@article{9df97e50ab5011ddb5e9000ea68e967b,
title = "GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.",
abstract = "BACKGROUND: Glucagon-like peptide-2 is thought to act as a growth factor for the gut, but the localization of the GLP-2 receptor and mechanism of action on epithelial growth is unclear. METHODS AND RESULTS: We found glucagon-like peptide-2 (GLP-2) receptors mainly on subepithelial myofibroblasts in rat, mouse, marmoset and human small and large intestine by immunohistochemistry and in situ hybridisation. By double labelling we found that these GLP-2 receptor immunoreactive cells also produce smooth muscle actin and keratinocyte growth factor (KGF). By subcutaneous infusion of either GLP-2 alone, GLP-2 plus KGF antibody, KGF antibody alone or saline in mice, we found that KGF antibody abolished the growth promoting effect of GLP-2 in the large intestine, but not in the small intestine. CONCLUSIONS: Our findings suggest that GLP-2 in the gut acts by activating receptors on the subepithelial myofibroblasts, causing the release of growth factors, which in turn stimulate intestinal growth.",
author = "Cathrine {\O}rskov and Bolette Hartmann and Poulsen, {Steen Seier} and Jesper Thulesen and Hare, {Kristine Juul} and Holst, {Jens Juul}",
note = "Keywords: Actins; Animals; Cell Proliferation; Colon; Female; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Fibroblasts; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Mice; Peptides; Rats; Receptors, Glucagon",
year = "2005",
doi = "10.1016/j.regpep.2004.07.009",
language = "English",
volume = "124",
pages = "105--12",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "1-3",

}

RIS

TY - JOUR

T1 - GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.

AU - Ørskov, Cathrine

AU - Hartmann, Bolette

AU - Poulsen, Steen Seier

AU - Thulesen, Jesper

AU - Hare, Kristine Juul

AU - Holst, Jens Juul

N1 - Keywords: Actins; Animals; Cell Proliferation; Colon; Female; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Fibroblasts; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Mice; Peptides; Rats; Receptors, Glucagon

PY - 2005

Y1 - 2005

N2 - BACKGROUND: Glucagon-like peptide-2 is thought to act as a growth factor for the gut, but the localization of the GLP-2 receptor and mechanism of action on epithelial growth is unclear. METHODS AND RESULTS: We found glucagon-like peptide-2 (GLP-2) receptors mainly on subepithelial myofibroblasts in rat, mouse, marmoset and human small and large intestine by immunohistochemistry and in situ hybridisation. By double labelling we found that these GLP-2 receptor immunoreactive cells also produce smooth muscle actin and keratinocyte growth factor (KGF). By subcutaneous infusion of either GLP-2 alone, GLP-2 plus KGF antibody, KGF antibody alone or saline in mice, we found that KGF antibody abolished the growth promoting effect of GLP-2 in the large intestine, but not in the small intestine. CONCLUSIONS: Our findings suggest that GLP-2 in the gut acts by activating receptors on the subepithelial myofibroblasts, causing the release of growth factors, which in turn stimulate intestinal growth.

AB - BACKGROUND: Glucagon-like peptide-2 is thought to act as a growth factor for the gut, but the localization of the GLP-2 receptor and mechanism of action on epithelial growth is unclear. METHODS AND RESULTS: We found glucagon-like peptide-2 (GLP-2) receptors mainly on subepithelial myofibroblasts in rat, mouse, marmoset and human small and large intestine by immunohistochemistry and in situ hybridisation. By double labelling we found that these GLP-2 receptor immunoreactive cells also produce smooth muscle actin and keratinocyte growth factor (KGF). By subcutaneous infusion of either GLP-2 alone, GLP-2 plus KGF antibody, KGF antibody alone or saline in mice, we found that KGF antibody abolished the growth promoting effect of GLP-2 in the large intestine, but not in the small intestine. CONCLUSIONS: Our findings suggest that GLP-2 in the gut acts by activating receptors on the subepithelial myofibroblasts, causing the release of growth factors, which in turn stimulate intestinal growth.

U2 - 10.1016/j.regpep.2004.07.009

DO - 10.1016/j.regpep.2004.07.009

M3 - Journal article

C2 - 15544847

VL - 124

SP - 105

EP - 112

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 1-3

ER -

ID: 8418118