Jens Høiriis Nielsen

Jens Høiriis Nielsen

Emeritus

Member of:

    ORCID: 0000-0001-8252-3048

    Introductory remarks on publicationslist

    153 scientific publications including 96 original papers, 3 patent applications and 54 reviews book chapters and conference proceedings. In addition app. abstracts and >250 invited lectures.


    Publication year:
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    1 - 50 out of 117Page size: 50
    1. 2024
    2. Published

      Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells

      Ghiasi, S. M., Marchetti, P., Piemonti, L., Nielsen, Jens Høiriis, Porse, Bo Torben, Mandrup-Poulsen, Thomas & Rutter, G. A., 2024, In: Frontiers in Endocrinology. 15, 13 p., 1359147.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 2022
    4. Published

      High-Intensity Interval Training Improves Cardiac Function by miR-206 Dependent HSP60 Induction in Diabetic Rats

      Delfan, M., Amadeh Juybari, R., Gorgani-Firuzjaee, S., Nielsen, Jens Høiriis, Delfan, N., Laher, I., Saeidi, A., Granacher, U. & Zouhal, H., 2022, In: Frontiers in Cardiovascular Medicine. 9, 11 p., 927956.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Fetal Programming of the Endocrine Pancreas: Impact of a Maternal Low-Protein Diet on Gene Expression in the Perinatal Rat Pancreas

      Winkel, L., Rasmussen, Morten Arendt, Larsen, L., Dalgaard, L. T. & Nielsen, Jens Høiriis, 2022, In: International Journal of Molecular Sciences. 23, 19, 21 p., 11057.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. 2020
    7. Published

      Regulation of integrin alpha 6A by lactogenic hormones in rat pancreatic beta-cells: Implications for the physiological adaptation to pregnancy

      Moldrup, A., Lindberg, M. N., Galsgaard, E. D., Henriksen, U., Dalgaard, L. T. & Nielsen, Jens Høiriis, 2020, In: Acta Physiologica. 229, 3, 13 p., 13454.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Possible mechanisms involved in improved beta cell function in pregnant women with type 1 diabetes

      Nalla, A., Ringholm, L., Sorensen, S. N., Damm, Peter, Mathiesen, Elisabeth & Nielsen, Jens Høiriis, 2020, In: Heliyon. 6, 8, 6 p., 04569.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. 2018
    10. Published

      Localization of microRNA-375 in perinatal rat pancreas

      Larsen, L., Rosenstierne, M. W., Nielsen, Jens Høiriis & Dalgaard, L. T., 2018, In: Non-Coding RNAs in Endocrinology. 3, p. 1-4

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Trefoil factor 3 in perinatal pancreas is increased by gestational low protein diet and associated with accelerated beta-cell maturation

      Winkel, L., Bagge, A., Larsen, L., Haase, T. N., Rasmussen, M., Lykke, J., Holmgaard, D. B., Thim, L., Nielsen, Jens Høiriis & Dalgaard, L. T., 2018, In: Islets. 10, 3, p. 124–135

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. 2017
    13. Published

      Impact of maternal obesity and diabetes on fetal pancreatic development

      Nielsen, Jens Høiriis, Jaksch, C. A. M., Lessi, I. & Damasceno, D. C., Jun 2017, Fetal and Early Postnatal Programming and its Influence on Adult Health. Boca Raton: CRC Press, p. 125-140 16 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    14. 2016
    15. Published

      Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo

      Horn, S., Kirkegaard, J. S., Hoelper, S., Seymour, Philip Allan, Rescan, C., Nielsen, Jens Høiriis, Madsen, O. D., Jensen, J. N., Kruger, M., Gronborg, M. & Ahnfelt-Rønne, J., 2016, In: Molecular endocrinology (Baltimore, Md.). 30, 1, p. 133-143 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Effect of Diabetes on Circulating Pancreatic Hormones in Pregnant Rats and Their Offspring

      Iessi, I. L., Sinzato, Y. K., Gallego, F. Q., Nielsen, Jens Høiriis & Damasceno, D. C., Sep 2016, In: Hormone and Metabolic Research. 48, 10, p. 682-686 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Beta cell adaptation in pregnancy: a tribute to Claes Hellerström

      Nielsen, Jens Høiriis, May 2016, In: Upsala Journal of Medical Sciences. 121, 2, p. 151-154 4 p.

      Research output: Contribution to journal › Review › Research › peer-review

    18. Published

      β-Cell Adaptability during Pregnancy

      Nielsen, Jens Høiriis, Horn, S., Kirkegaard, J. S., Nalla, A. & Søstrup, B., 2016, Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes. Bentham Science Publishers, p. 123-168 45 p. (Current and Future Developments in Physiology, Vol. 1).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    19. 2014
    20. Published

      CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients

      Fløyel, T., Brorsson, C., Nielsen, L. B., Miani, M., Bang-Berthelsen, C. H., Friedrichsen, M., Overgaard, A. J., Berchtold, L. A., Wiberg, A., Poulsen, P., Hansen, L., Rosinger, S., Boehm, B. O., Ram, R., Nguyen, Q., Mehta, M., Morahan, G., Concannon, P., Bergholdt, R., Nielsen, J. H. & 7 others, Reinheckel, T., von Herrath, M., Vaag, Allan, Eizirik, D. L., Mortensen, H. B., Størling, J. & Pociot, Flemming, 15 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. 10305-10310 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      The mitogenic effect of Gas6 on pancreatic beta cells is mediated via the receptor tyrosine kinase Axl

      Haase, T. N., Gustafsson, A., Nalla, A., Ringholm, L., Damm, Peter, Mathiesen, Elisabeth, Dahlback, B., Billestrup, Nils & Nielsen, Jens Høiriis, Sep 2014, In: Diabetologia. 57, 1 Suppl, p. S173-S174 408.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    22. Published

      Programming of glucose-insulin homoeostasis: long-term consequences of pre-natal versus early post-natal nutrition insults. Evidence from a sheep model

      Kongsted, A. H., Tygesen, M. P., Husted, S. V., Oliver, M. H., Tolver, Anders, Christensen, V. G., Nielsen, Jens Høiriis & Nielsen, M. O., 2014, In: Acta Physiologica (Print). 210, 1, p. 84-98 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Functional characteristics of neonatal rat β cells with distinct markers

      Martens, G. A., Motté, E., Kramer, G., Stangé, G., Gaarn, L. W., Hellemans, K., Nielsen, Jens Høiriis, Aerts, J. M., Ling, Z. & Pipeleers, D., Feb 2014, In: Journal of Molecular Endocrinology. 52, 1, p. 11-28 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy

      Nalla, A., Ringholm, L., Søstrup, B., Højrup, P., Thim, L., Levery, S. B., Vakhrushev, Sergey, Billestrup, Nils, Mathiesen, Elisabeth, Damm, Peter & Nielsen, Jens Høiriis, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1181-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Impact of fetal and neonatal environment on beta cell function and development of diabetes

      Nielsen, Jens Høiriis, Haase, T. N., Jaksch, C., Nalla, A., Søstrup, B., Nalla, A. A., Larsen, L., Rasmussen, M., Dalgaard, L. T., Gaarn, L. W., Thams, P., Kofod, H. & Billestrup, Nils, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1109-22 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Co-ordinated regulation of neurogenin-3 expression in the maternal and fetal pancreas during pregnancy

      Søstrup, B., Gaarn, L. W., Nalla, A., Billestrup, Nils & Nielsen, Jens Høiriis, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1190-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. 2013
    28. Published

      Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell

      Haase, T. N., Rasmussen, M., Jaksch, C. A. M., Gaarn, L. W., Petersen, C. K., Billestrup, Nils & Nielsen, Jens Høiriis, Apr 2013, In: Diabetologia. 56, 4, p. 763-773 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Beta Cell Workshop 2013 Kyoto

      Heller, R. S., Madsen, O. D. & Nielsen, Jens Høiriis, 11 Jun 2013, In: Islets. 5, 3, p. 107-110 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. 2012
    31. Published

      MicroRNA-29a is up-regulated in beta-cells by glucose and decreases glucose-stimulated insulin secretion

      Bagge, A., Clausen, T. R., Larsen, S., Ladefoged, M., Rosenstierne, M. W., Larsen, L., Vang, O., Nielsen, Jens Høiriis & Dalgaard, L. T., 21 Sep 2012, In: Biochemical and Biophysical Research Communications. 426, 2, p. 266-72 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Workshop on programming beta cell development, impairment and regeneration

      Heller, S. & Nielsen, Jens Høiriis, 2012, In: Islets. 4, 2, p. 119-22 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. 2011
    34. Published

      Suppression of FAT/CD36 mRNA by human growth hormone in pancreatic ß-cells

      Dalgaard, L. T., Thams, P. G., Gaarn, L. W., Jensen, J., Lee, Y. C. & Nielsen, Jens Høiriis, 1 Jul 2011, In: Biochemical and Biophysical Research Communications. 410, 2, p. 345-350 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Expression and Localization of microRNAs in Perinatal Rat Pancreas: Role of miR-21 in Regulation of Cholesterol Metabolism

      Larsen, L., Rosenstierne, M. W., Gaarn, L. W., Bagge, A., Pedersen, L., Dahmcke, C. M., Nielsen, Jens Høiriis & Dalgaard, L. T., 11 Oct 2011, In: PLOS ONE. 6, 10, p. e25997 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. 2010
    37. Published

      AKAP 18 a and g have opposing effects on insulin release in INS 1E cells

      Nielsen, Jens Høiriis, Lee, Y. C. & Thams, P. G., 2010, In: FEBS Letter. 584, p. 81-85

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. 2009
    39. Published

      Expression profiling of human genetic and protein interaction networks in type 1 diabetes

      Bergholdt, R., Brorsson, C., Lage, K., Nielsen, Jens Høiriis, Brunak, S. & Pociot, Flemming, 2009, In: PLoS ONE. 4, 7, p. e6250

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      CXCL12/SDF-1 over-expression in human insulinomas and its biological relevance

      Ilhan, A., Nabokikh, A., Maj, M., Vidakovic, M., Nielsen, Jens Høiriis, Prikoszovich, T., Niederle, B., Base, W., Luger, A. & Wagner, L., 2009, In: Molecular and Cellular Endocrinology. 298, 1-2, p. 1-10 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. 2008
    42. Published

      STAT5 activity in pancreatic beta cells.

      Dalgaard, L. T., Billestrup, N. & Nielsen, Jens Høiriis, 2008, In: Expert Review of Endocrinology & Metabolism. 3, 4, p. 423-439 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Regulation of beta cell replication.

      Lee, Y. C. & Nielsen, Jens Høiriis, 2008, In: Molecular and Cellular Endocrinology.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. 2007
    45. Published

      Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets

      Bergholdt, R., Karlsen, A. E., Hagedorn, P. H., Aalund, M., Nielsen, Jens Høiriis, Kruhoffer, M., Orntoft, T., Wang, H., Wollheim, C. B., Nerup, J. & Pociot, Flemming, 2007, In: Genes and Immunity. 8, 3, p. 232-238 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Remarkable heterogeneity displayed by oval cells in rat and mouse models of stem cell-mediated liver regeneration.

      Jelnes, P., Santoni-Rugiu, E., Rasmussen, M., Friis, S. L., Nielsen, Jens Høiriis, Tygstrup, N. & Bisgaard, Hanne Cathrine, 2007, In: Hepatology. 45, 6, p. 1462-70 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Reduced TGF-beta1 expression and its target genes in human insulinomas

      Nabokikh, A., Ilhan, A., Bilban, M., Gartner, W., Vila, G., Niederle, B., Nielsen, Jens Høiriis, Wagner, O., Base, W., Luger, A. & Wagner, L., 2007, In: Experimental and Clinical Endocrinology and Diabetes. 115, 10, p. 674-682 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. 2006
    49. Published

      Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.

      Friedrichsen, B. N., Neubauer, N., Lee, Y. C., Gram, V. K., Blume, N., Petersen, J. S., Nielsen, Jens Høiriis & Møldrup, A., 2006, In: Journal of Endocrinology. 188, 3, p. 481-92 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes.

      Jackerott, M., Møldrup, A., Thams, P., Galsgaard, E. D., Knudsen, J., Lee, Y. C. & Nielsen, Jens Høiriis, 2006, In: Diabetes. 55, 10, p. 2705-12 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      Trefoil factors are expressed in human and rat endocrine pancreas: differential regulation by growth hormone.

      Jackerott, M., Lee, Y. C., Møllgård, Kjeld, Kofod, H., Jensen, J., Rohleder, S., Neubauer, N., Gaarn, L. W., Lykke, J., Dodge, R., Dalgaard, L. T., Søstrup, B., Jensen, D. B., Thim, L., Nexø, E., Thams, P., Bisgaard, Hanne Cathrine & Nielsen, Jens Høiriis, 2006, In: Endocrinology. 147, 12, p. 5752-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Cytokine signalling in embryonic stem cells.

      Kristensen, D. M., Kalisz, M. & Nielsen, Jens Høiriis, 2006, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 113, 11-12, p. 756-72 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. 2005
    54. Published

      STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric oxide production.

      Jensen, J., Galsgaard, E. D., Karlsen, A. E., Lee, Y. C. & Nielsen, Jens Høiriis, 2005, In: Journal of Endocrinology. 187, 1, p. 25-36 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. 2004
    56. Published

      Development and Life Cycle of a β-Cell

      Serup, P. & Nielsen, Jens Høiriis, 2004, International Textbook of Diabetes Mellitus, Third Edition. Chichester: IEEE Computer Society Press, p. 59-78

      Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research

    57. 2003
    58. Published

      Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells: possible physiological implications

      Friedrichsen, B. N., Carlsson, C., Møldrup, A., Michelsen, B., Jensen, C. H., Teisner, B. & Nielsen, Jens Høiriis, Feb 2003, In: Journal of Endocrinology. 176, 2, p. 257-66 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells

      Friedrichsen, B. N., Richter, H. E., Hansen, J. A., Rhodes, C. J., Nielsen, Jens Høiriis, Billestrup, Nils & Møldrup, A., May 2003, In: Molecular endocrinology (Baltimore, Md.). 17, 5, p. 945-58 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. 2001
    61. Published

      Expression of SMAD signal transduction molecules in the pancreas

      Brorson, M., Hougaard, D., Nielsen, Jens Høiriis, Tornehave, D. & Larsson, L., 2001, In: Histochemistry and Cell Biology. 116, 3, p. 263-7 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Growth hormone - and prolactin- induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5)

      Friedrichsen, B. N., Galsgaard, E. D., Nielsen, Jens Høiriis & Møldrup, A., 2001, In: Molecular Endocrinology. 15, p. 136-148

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Expression of dominant-negative STAT5 inhibits growth hormone- and prolactin-induced proliferation of insulin-producing cells

      Galsgaard, E. D., Friedrichsen, B. N., Møldrup, A. & Nielsen, Jens Høiriis, 2001, In: Diabetes. 50 Suppl 1, Vol.50, Suppl.1, p. 40-41

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. Published

      Suppressor of cytokine signaling 3 (SOCS-3) protects ß-cells against interleukin-1ß- and interferon-¿- mediated toxicity

      Karlsen, A. E., Rønn, S. G., Lindberg, K., Jonannesen, J., Galsgaard, E. D., Pociot, F., Nielsen, Jens Høiriis, Mandrup-Poulsen, T. R., Nerup, J. & Billestrup, N., 2001, In: Proceedings of the National Academy of Science of the United States of America. Vol.98, p. 12191-12196

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Published

      Regulation of ß-cell mass by hormones and growth factors

      Nielsen, Jens Høiriis, Galsgaard, E. D., Møldrup, A., Friedrichsen, B. N., Billestrup, N., Hansen, J. A., Lee, Y. C. & Carlson, C., 2001, In: Diabetes. Vol.50. Suppl.1, p. 25-29

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. 1999
    67. Published

      Regulation of prolactin receptor (PRLR) gene expression in insulin-producing cells. Prolactin and growth hormone activate one of the rat prlr gene promoters via STAT5a and STAT5b

      Galsgaard, E. D., Møldrup, A. & Nielsen, Jens Høiriis, 25 Jun 1999, In: The Journal of Biological Chemistry. 274, 26, p. 18686-92 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins

      Hansen, J. A., Lindberg, K., Hilton, D. J., Nielsen, Jens Høiriis & Billestrup, Nils, Nov 1999, In: Molecular endocrinology (Baltimore, Md.). 13, 11, p. 1832-43 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Published

      Developmental expression of proprotein convertase 1/3 in the rat

      Lee, Y. C., Damholt, A. B., Billestrup, Nils, Kisbye, T., Galante, P., Michelsen, B., Kofod, H. & Nielsen, Jens Høiriis, 10 Sep 1999, In: Molecular and Cellular Endocrinology. 155, 1-2, p. 27-35 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      Beta cell proliferation and growth factors

      Nielsen, Jens Høiriis, Svensson, C., Møldrup, A., Galsgaard, E. D. & Billestrup, Nils, Jan 1999, In: Journal of Molecular Medicine. 77, 1, p. 62-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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