Jens Høiriis Nielsen

Jens Høiriis Nielsen

Emeritus

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    ORCID: 0000-0001-8252-3048

    Introductory remarks on publicationslist

    153 scientific publications including 96 original papers, 3 patent applications and 54 reviews book chapters and conference proceedings. In addition app. abstracts and >250 invited lectures.


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    1. Published

      Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation

      Allevato, G., Billestrup, Nils, Goujon, L., Galsgaard, E. D., Norstedt, G., Postel-Vinay, M. C., Kelly, P. A. & Nielsen, Jens Høiriis, 21 Jul 1995, In: The Journal of Biological Chemistry. 270, 29, p. 17210-4 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine

      Andersen, H. U., Mauricio, D., Karlsen, A. E., Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, Feb 1996, In: European Journal of Endocrinology. 134, 2, p. 251-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

      Baekkeskov, S., Marner, B., Bilde, T., Ludvigsson, J., Lernmark, A. & Nielsen, Jens Høiriis, 8 Jul 1982, In: Nature. 298, 5870, p. 167-9 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      MicroRNA-29a is up-regulated in beta-cells by glucose and decreases glucose-stimulated insulin secretion

      Bagge, A., Clausen, T. R., Larsen, S., Ladefoged, M., Rosenstierne, M. W., Larsen, L., Vang, O., Nielsen, Jens Høiriis & Dalgaard, L. T., 21 Sep 2012, In: Biochemical and Biophysical Research Communications. 426, 2, p. 266-72 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans

      Bendtzen, K., Mandrup-Poulsen, Thomas, Nerup, J., Dinarello, C. A., Svenson, M. & Nielsen, Jens Høiriis, 20 Jun 1986, In: Science (New York, N.Y.). 232, 4757, p. 1545-7 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets

      Bergholdt, R., Karlsen, A. E., Hagedorn, P. H., Aalund, M., Nielsen, Jens Høiriis, Kruhoffer, M., Orntoft, T., Wang, H., Wollheim, C. B., Nerup, J. & Pociot, Flemming, 2007, In: Genes and Immunity. 8, 3, p. 232-238 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Expression profiling of human genetic and protein interaction networks in type 1 diabetes

      Bergholdt, R., Brorsson, C., Lage, K., Nielsen, Jens Høiriis, Brunak, S. & Pociot, Flemming, 2009, In: PLoS ONE. 4, 7, p. e6250

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      The stimulatory effect of growth hormone, prolactin, and placental lactogen on beta-cell proliferation is not mediated by insulin-like growth factor-I

      Billestrup, Nils & Nielsen, Jens Høiriis, Aug 1991, In: Endocrinology. 129, 2, p. 883-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Growth hormone receptor C-terminal domains required for growth hormone-induced intracellular free Ca2+ oscillations and gene transcription

      Billestrup, Nils, Bouchelouche, P., Allevato, G., Ilondo, M. & Nielsen, Jens Høiriis, 28 Mar 1995, In: Proceedings of the National Academy of Sciences of the United States of America. 92, 7, p. 2725-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Growth of the endocrine pancreas: the role of somatolactogenic hormones and receptors

      Billestrup, Nils, Møldrup, A., Allevato, G., Petersen, Erik Brinch, Pedersen, Johan, Hansen, J. A. & Nielsen, Jens Høiriis, Feb 1993, In: Biochemical Society Transactions. 21, 1, p. 146-9 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Molecular dissection of the growth hormone receptor. Identification of distinct cytoplasmic domains corresponding to different signaling pathways

      Billestrup, Nils, Allevato, G., Møldrup, A., Galsgaard, E. D., Amstrup, J., Hansen, J. A., Svensson, C. & Nielsen, Jens Høiriis, 7 Sep 1995, In: Annals of the New York Academy of Sciences. 766, p. 481-3 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Introduction of exogenous growth hormone receptors augments growth hormone-responsive insulin biosynthesis in rat insulinoma cells

      Billestrup, Nils, Møldrup, A., Serup, Palle, Mathews, L. S., Norstedt, G. & Nielsen, Jens Høiriis, Sep 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 18, p. 7210-4 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Molecular mechanism of growth hormone signalling

      Billestrup, Nils, Hansen, J. A., Hansen, L. H., Møldrup, A., Galsgaard, E. D. & Nielsen, Jens Høiriis, Apr 1998, In: Endocrine Journal. 45 Suppl, p. S41-5

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Identification of intracellular domains in the growth hormone receptor involved in signal transduction

      Billestrup, Nils, Allevato, G., Norstedt, G., Møldrup, A. & Nielsen, Jens Høiriis, Jul 1994, In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 206, 3, p. 205-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Expression of SMAD signal transduction molecules in the pancreas

      Brorson, M., Hougaard, D., Nielsen, Jens Høiriis, Tornehave, D. & Larsson, L., 2001, In: Histochemistry and Cell Biology. 116, 3, p. 263-7 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Binding of zinc to insulin and some insulin derivatives studied by paper electrophoresis

      Brunfeldt, K., Hansen, B. A. & Nielsen, Jens Høiriis, Jul 1969, In: Acta Endocrinologica. 61, 3, p. 561-76 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Direct long-term effect of hydrocortisone on insulin and glucagon release from mouse pancreatic islets in tissue culture

      Brunstedt, J. & Nielsen, Jens Høiriis, Apr 1981, In: Acta Endocrinologica. 96, 4, p. 498-504 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Long-term effect of pH on B-cell function in isolated islets of Langerhans in tissue culture

      Brunstedt, J. & Nielsen, Jens Høiriis, Sep 1978, In: Diabetologia. 15, 3, p. 181-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Preservation of beta cell function in adult human pancreatic islets for several months in vitro

      Brunstedt, J., Andersson, A., Frimodt-Møller, C. & Nielsen, Jens Høiriis, Feb 1979, In: Diabetologia. 16, 2, p. 97-100 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas

      Carlsson, C., Tornehave, D., Lindberg, K., Galante, P., Billestrup, Nils, Michelsen, B., Larsson, L. I. & Nielsen, Jens Høiriis, Sep 1997, In: Endocrinology. 138, 9, p. 3940-8 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Direct long-term effects of L-asparaginase on rat and human pancreatic islets

      Clausen, N. & Nielsen, Jens Høiriis, Aug 1989, In: Pediatric Research. 26, 2, p. 158-61 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Beta-cell ontogeny: growth and death

      Corbett, J., Serup, Palle, Bonner-Weir, S. & Nielsen, Jens Høiriis, Oct 1997, In: Diabetologia. 40 Suppl 3, p. B27-32

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      STAT5 activity in pancreatic beta cells.

      Dalgaard, L. T., Billestrup, N. & Nielsen, Jens Høiriis, 2008, In: Expert Review of Endocrinology & Metabolism. 3, 4, p. 423-439 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Suppression of FAT/CD36 mRNA by human growth hormone in pancreatic ß-cells

      Dalgaard, L. T., Thams, P. G., Gaarn, L. W., Jensen, J., Lee, Y. C. & Nielsen, Jens Høiriis, 1 Jul 2011, In: Biochemical and Biophysical Research Communications. 410, 2, p. 345-350 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      High-Intensity Interval Training Improves Cardiac Function by miR-206 Dependent HSP60 Induction in Diabetic Rats

      Delfan, M., Amadeh Juybari, R., Gorgani-Firuzjaee, S., Nielsen, Jens Høiriis, Delfan, N., Laher, I., Saeidi, A., Granacher, U. & Zouhal, H., 2022, In: Frontiers in Cardiovascular Medicine. 9, 11 p., 927956.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Biosynthesis and release of thyrotropin-releasing hormone immunoreactivity in rat pancreatic islets in organ culture. Effects of age, glucose, and streptozotocin

      Dolva, L. O., Welinder, B. S., Hanssen, K. F. & Nielsen, Jens Høiriis, Dec 1983, In: The Journal of Clinical Investigation. 72, 6, p. 1867-73 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Stimulatory effect of serum from diabetic patients on insulin release from mouse pancreatic islets maintained in tissue culture

      Eff, C., Deckert, T., Andersson, A. & Nielsen, Jens Høiriis, 1981, In: Diabetologia. 20, 1, p. 60-5 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients

      Fløyel, T., Brorsson, C., Nielsen, L. B., Miani, M., Bang-Berthelsen, C. H., Friedrichsen, M., Overgaard, A. J., Berchtold, L. A., Wiberg, A., Poulsen, P., Hansen, L., Rosinger, S., Boehm, B. O., Ram, R., Nguyen, Q., Mehta, M., Morahan, G., Concannon, P., Bergholdt, R., Nielsen, J. H. & 7 others, Reinheckel, T., von Herrath, M., Vaag, Allan, Eizirik, D. L., Mortensen, H. B., Størling, J. & Pociot, Flemming, 15 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. 10305-10310 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells: possible physiological implications

      Friedrichsen, B. N., Carlsson, C., Møldrup, A., Michelsen, B., Jensen, C. H., Teisner, B. & Nielsen, Jens Høiriis, Feb 2003, In: Journal of Endocrinology. 176, 2, p. 257-66 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells

      Friedrichsen, B. N., Richter, H. E., Hansen, J. A., Rhodes, C. J., Nielsen, Jens Høiriis, Billestrup, Nils & Møldrup, A., May 2003, In: Molecular endocrinology (Baltimore, Md.). 17, 5, p. 945-58 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.

      Friedrichsen, B. N., Neubauer, N., Lee, Y. C., Gram, V. K., Blume, N., Petersen, J. S., Nielsen, Jens Høiriis & Møldrup, A., 2006, In: Journal of Endocrinology. 188, 3, p. 481-92 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Growth hormone - and prolactin- induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5)

      Friedrichsen, B. N., Galsgaard, E. D., Nielsen, Jens Høiriis & Møldrup, A., 2001, In: Molecular Endocrinology. 15, p. 136-148

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Effect of 5'-flanking sequence deletions on expression of the human insulin gene in transgenic mice

      Fromont-Racine, M., Bucchini, D., gjc556, gjc556, Desbois, P., Linde, S., Saulnier, C., Ripoche, M. A., Jami, J., Pictet, R. & Nielsen, Jens Høiriis, May 1990, In: Molecular endocrinology (Baltimore, Md.). 4, 5, p. 669-77 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Regulation of prolactin receptor (PRLR) gene expression in insulin-producing cells. Prolactin and growth hormone activate one of the rat prlr gene promoters via STAT5a and STAT5b

      Galsgaard, E. D., Møldrup, A. & Nielsen, Jens Høiriis, 25 Jun 1999, In: The Journal of Biological Chemistry. 274, 26, p. 18686-92 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Expression of dominant-negative STAT5 inhibits growth hormone- and prolactin-induced proliferation of insulin-producing cells

      Galsgaard, E. D., Friedrichsen, B. N., Møldrup, A. & Nielsen, Jens Høiriis, 2001, In: Diabetes. 50 Suppl 1, Vol.50, Suppl.1, p. 40-41

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene

      Galsgaard, E. D., Gouilleux, F., Groner, B., Serup, Palle, Billestrup, Nils & Nielsen, Jens Høiriis, Jun 1996, In: Molecular endocrinology (Baltimore, Md.). 10, 6, p. 652-60 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells

      Ghiasi, S. M., Marchetti, P., Piemonti, L., Nielsen, Jens Høiriis, Porse, Bo Torben, Mandrup-Poulsen, Thomas & Rutter, G. A., 2024, In: Frontiers in Endocrinology. 15, 13 p., 1359147.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Cytoplasmic sequences of the growth hormone receptor necessary for signal transduction

      Goujon, L., Allevato, G., Simonin, G., Paquereau, L., Le Cam, A., Clark, J., Djiane, J., Postel-Vinay, M. C., Nielsen, Jens Høiriis & Edery, M., 1 Feb 1994, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 3, p. 957-61 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling

      Gromada, J., Bokvist, K., Ding, W. G., Holst, Jens Juul, Nielsen, Jens Høiriis & Rorsman, P., 1998, In: Diabetes. 47, 1, p. 57-65 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell

      Haase, T. N., Rasmussen, M., Jaksch, C. A. M., Gaarn, L. W., Petersen, C. K., Billestrup, Nils & Nielsen, Jens Høiriis, Apr 2013, In: Diabetologia. 56, 4, p. 763-773 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      The mitogenic effect of Gas6 on pancreatic beta cells is mediated via the receptor tyrosine kinase Axl

      Haase, T. N., Gustafsson, A., Nalla, A., Ringholm, L., Damm, Peter, Mathiesen, Elisabeth, Dahlback, B., Billestrup, Nils & Nielsen, Jens Høiriis, Sep 2014, In: Diabetologia. 57, 1 Suppl, p. S173-S174 408.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    42. Published

      Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets

      Hansen, B. S., Linde, S., Spinas, G. A., Welinder, B. S., Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, 1988, In: Biomedica Biochimica Acta. 47, 4-5, p. 305-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      New approaches to therapy and diagnosis of diabetes

      Hansen, B. A., Lernmark, A., Owerbach, D., Welinder, B. & Nielsen, Jens Høiriis, Feb 1982, In: Diabetologia. 22, 2, p. 61-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Variations in insulin responsiveness in rat fat cells are due to metabolic differences rather than insulin binding

      Hansen, F. M., Nilsson, P., Sonne, O., Hustvedt, B. E., Nilsson-Ehle, P., Løvø, A. & Nielsen, Jens Høiriis, Feb 1983, In: Diabetologia. 24, 2, p. 131-5 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      The influence of sexual hormones on lipogenesis and lipolysis in rat fat cells

      Hansen, F. M., Fahmy, N. & Nielsen, Jens Høiriis, Dec 1980, In: Acta Endocrinologica. 95, 4, p. 566-70 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      The influence of body weight and cell size on lipogenesis and lipolysis of isolated rat fat cells

      Hansen, F. M., Gliemann, J. & Nielsen, Jens Høiriis, 5 Dec 1974, In: European Journal of Clinical Investigation. 4, 6, p. 411-8 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      The role of GH receptor tyrosine phosphorylation in Stat5 activation

      Hansen, J. A., Hansen, Lars Hestbjerg, Wang, X., Kopchick, J. J., Gouilleux, F., Groner, B., Møldrup, A., Galsgaard, E. D., Nielsen, Jens Høiriis & Billestrup, Nils, Jun 1997, In: Journal of Molecular Endocrinology. 18, 3, p. 213-21 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins

      Hansen, J. A., Lindberg, K., Hilton, D. J., Nielsen, Jens Høiriis & Billestrup, Nils, Nov 1999, In: Molecular endocrinology (Baltimore, Md.). 13, 11, p. 1832-43 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Characterization of the inhibitory effect of growth hormone on primary preadipocyte differentiation

      Hansen, L. H., Madsen, B., Teisner, B., Nielsen, Jens Høiriis & Billestrup, Nils, Aug 1998, In: Molecular endocrinology (Baltimore, Md.). 12, 8, p. 1140-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation

      Hansen, L. H., Wang, X., Kopchick, J. J., Bouchelouche, P., Galsgaard, E. D., Nielsen, Jens Høiriis & Billestrup, Nils, 24 May 1996, In: The Journal of Biological Chemistry. 271, 21, p. 12669-73 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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