Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues

Research output: Contribution to journalComment/debateResearchpeer-review

We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.
Original languageEnglish
Article numbere1692643
JournalMolecular & Cellular Oncology
Issue number1
Number of pages3
Publication statusPublished - 2020

    Research areas

  • Proteomics, tyrosine kinase signaling, interaction proteomics, oncogenic signaling rewiring

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