Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues

Research output: Contribution to journal › Comment/debate › Research › peer-review

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Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues. / Emdal, Kristina B.; Lundby, Alicia.

In: Molecular & Cellular Oncology, Vol. 7, No. 1, e1692643, 2020.

Research output: Contribution to journal › Comment/debate › Research › peer-review

Harvard

Emdal, KB & Lundby, A 2020, 'Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues', Molecular & Cellular Oncology, vol. 7, no. 1, e1692643. https://doi.org/10.1080/23723556.2019.1692643

APA

Emdal, K. B., & Lundby, A. (2020). Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues. Molecular & Cellular Oncology, 7(1), [e1692643]. https://doi.org/10.1080/23723556.2019.1692643

Vancouver

Emdal KB, Lundby A. Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues. Molecular & Cellular Oncology. 2020;7(1). e1692643. https://doi.org/10.1080/23723556.2019.1692643

Author

Emdal, Kristina B. ; Lundby, Alicia. / Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues. In: Molecular & Cellular Oncology. 2020 ; Vol. 7, No. 1.

Bibtex

@article{10d66615bdec4eaa8a4a11c525fdd371,
title = "Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues",
abstract = "We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.",
keywords = "Proteomics, tyrosine kinase signaling, interaction proteomics, oncogenic signaling rewiring",
author = "Emdal, {Kristina B.} and Alicia Lundby",
year = "2020",
doi = "10.1080/23723556.2019.1692643",
language = "English",
volume = "7",
journal = "Molecular & Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - Molecular switches in signaling networks as a mechanism of action for oncogenic mutations in proximity of tyrosine residues

AU - Emdal, Kristina B.

AU - Lundby, Alicia

PY - 2020

Y1 - 2020

N2 - We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.

AB - We developed a mass spectrometry-based proteomics strategy to study oncogenic phosphotyrosine signaling networks in tissues. We outlined epidermal growth factor-dependent phosphotyrosine signaling in lung tissue and discovered that cancer mutations in vicinity of phosphotyrosine sites can induce molecular switches in recruited protein complexes, which ultimately alter the signaling outcome of the network activation.

KW - Proteomics

KW - tyrosine kinase signaling

KW - interaction proteomics

KW - oncogenic signaling rewiring

U2 - 10.1080/23723556.2019.1692643

DO - 10.1080/23723556.2019.1692643

M3 - Comment/debate

C2 - 31993501

VL - 7

JO - Molecular & Cellular Oncology

JF - Molecular & Cellular Oncology

SN - 2372-3556

IS - 1

M1 - e1692643

ER -

ID: 232009636