Induction of DNA damage by oxidised amino acids and proteins
Research output: Contribution to journal › Journal article › peer-review
Exposure of amino acids, peptides and proteins to radicals in the presence of O2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO*), peroxyl (ROO*) and carbon-centred (R) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.
Original language | English |
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Journal | Biogerontology |
Volume | 3 |
Issue number | 1-2 |
Pages (from-to) | 95-102 |
Number of pages | 8 |
ISSN | 1389-5729 |
Publication status | Published - 2002 |
- Amino Acids, Animals, Cattle, DNA Damage, Electrophoresis, Agar Gel, Hydrogen Peroxide, Oxidation-Reduction, Proteins
Research areas
ID: 138278219