Induction of DNA damage by oxidised amino acids and proteins

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Induction of DNA damage by oxidised amino acids and proteins. / Luxford, Catherine; Dean, Roger T; Davies, Michael Jonathan.

In: Biogerontology, Vol. 3, No. 1-2, 2002, p. 95-102.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Luxford, C, Dean, RT & Davies, MJ 2002, 'Induction of DNA damage by oxidised amino acids and proteins', Biogerontology, vol. 3, no. 1-2, pp. 95-102.

APA

Luxford, C., Dean, R. T., & Davies, M. J. (2002). Induction of DNA damage by oxidised amino acids and proteins. Biogerontology, 3(1-2), 95-102.

Vancouver

Luxford C, Dean RT, Davies MJ. Induction of DNA damage by oxidised amino acids and proteins. Biogerontology. 2002;3(1-2):95-102.

Author

Luxford, Catherine ; Dean, Roger T ; Davies, Michael Jonathan. / Induction of DNA damage by oxidised amino acids and proteins. In: Biogerontology. 2002 ; Vol. 3, No. 1-2. pp. 95-102.

Bibtex

@article{d63e7584397945f1ac530b83a863cce8,
title = "Induction of DNA damage by oxidised amino acids and proteins",
abstract = "Exposure of amino acids, peptides and proteins to radicals in the presence of O2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO*), peroxyl (ROO*) and carbon-centred (R) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.",
keywords = "Amino Acids, Animals, Cattle, DNA Damage, Electrophoresis, Agar Gel, Hydrogen Peroxide, Oxidation-Reduction, Proteins",
author = "Catherine Luxford and Dean, {Roger T} and Davies, {Michael Jonathan}",
year = "2002",
language = "English",
volume = "3",
pages = "95--102",
journal = "Biogerontology",
issn = "1389-5729",
publisher = "Springer",
number = "1-2",

}

RIS

TY - JOUR

T1 - Induction of DNA damage by oxidised amino acids and proteins

AU - Luxford, Catherine

AU - Dean, Roger T

AU - Davies, Michael Jonathan

PY - 2002

Y1 - 2002

N2 - Exposure of amino acids, peptides and proteins to radicals in the presence of O2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO*), peroxyl (ROO*) and carbon-centred (R) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.

AB - Exposure of amino acids, peptides and proteins to radicals in the presence of O2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO*), peroxyl (ROO*) and carbon-centred (R) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.

KW - Amino Acids

KW - Animals

KW - Cattle

KW - DNA Damage

KW - Electrophoresis, Agar Gel

KW - Hydrogen Peroxide

KW - Oxidation-Reduction

KW - Proteins

M3 - Journal article

C2 - 12014851

VL - 3

SP - 95

EP - 102

JO - Biogerontology

JF - Biogerontology

SN - 1389-5729

IS - 1-2

ER -

ID: 138278219