Gestational Hypertension and High-Density Lipoprotein Function: An Explorative Study in Overweight/Obese Women of the DALI Cohort
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Gestational Hypertension and High-Density Lipoprotein Function : An Explorative Study in Overweight/Obese Women of the DALI Cohort. / Stadler, Julia T.; van Poppel, M. N. M.; Christoffersen, Christina; Hill, David; Wadsack, Christian; Simmons, David; Desoye, Gernot; Marsche, Gunther; DALI Core Investigator Grp.
In: Antioxidants, Vol. 12, No. 1, 68, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Gestational Hypertension and High-Density Lipoprotein Function
T2 - An Explorative Study in Overweight/Obese Women of the DALI Cohort
AU - Stadler, Julia T.
AU - van Poppel, M. N. M.
AU - Christoffersen, Christina
AU - Hill, David
AU - Wadsack, Christian
AU - Simmons, David
AU - Desoye, Gernot
AU - Marsche, Gunther
AU - DALI Core Investigator Grp, null
PY - 2023
Y1 - 2023
N2 - Gestational hypertension (GHTN) is associated with an increased cardiovascular risk for mothers and their offspring later in life. High-density lipoproteins (HDL) are anti-atherogenic by promoting efflux of cholesterol from macrophages and suppression of endothelial cell activation. Functional impairment of HDL in GHTN-complicated pregnancies may affect long-term health of both mothers and offspring. We studied functional parameters of maternal and neonatal HDL in 192 obese women (pre-pregnancy BMI >= 29), who were at high risk for GHTN. Maternal blood samples were collected longitudinally at
AB - Gestational hypertension (GHTN) is associated with an increased cardiovascular risk for mothers and their offspring later in life. High-density lipoproteins (HDL) are anti-atherogenic by promoting efflux of cholesterol from macrophages and suppression of endothelial cell activation. Functional impairment of HDL in GHTN-complicated pregnancies may affect long-term health of both mothers and offspring. We studied functional parameters of maternal and neonatal HDL in 192 obese women (pre-pregnancy BMI >= 29), who were at high risk for GHTN. Maternal blood samples were collected longitudinally at
KW - gestational hypertension
KW - HDL
KW - cholesterol efflux capacity
KW - paraoxonase-1
KW - apolipoprotein M
KW - pregnancy
KW - obesity
KW - APOLIPOPROTEIN-M
KW - CARDIOVASCULAR-DISEASE
KW - CHOLESTEROL EFFLUX
KW - PREECLAMPSIA
KW - PREGNANCY
KW - PROTEIN
KW - RISK
KW - POLYMORPHISMS
KW - CAPACITY
U2 - 10.3390/antiox12010068
DO - 10.3390/antiox12010068
M3 - Journal article
C2 - 36670930
VL - 12
JO - Antioxidants
JF - Antioxidants
SN - 2076-3921
IS - 1
M1 - 68
ER -
ID: 335690724