Generation and propagation of radical reactions on proteins

Research output: Contribution to journalJournal articleResearchpeer-review

The oxidation of proteins by free radicals is thought to play a major role in many oxidative processes within cells and is implicated in a number of human diseases as well as ageing. This review summarises information on the formation of radicals on peptides and proteins and how radical damage may be propagated and transferred within protein structures. The emphasis of this article is primarily on the deleterious actions of radicals generated on proteins, and their mechanisms of action, rather than on enzymatic systems where radicals are deliberately formed as transient intermediates. The final section of this review examines the control of protein oxidation and how such damage might be limited by antioxidants.

Original languageEnglish
JournalB B A - Reviews on Cancer
Issue number2-3
Pages (from-to)196-219
Number of pages24
Publication statusPublished - 2 Apr 2001

    Research areas

  • Alcohols, Animals, Antioxidants, Binding Sites, Electron Spin Resonance Spectroscopy, Free Radicals, Humans, Kinetics, Models, Chemical, Oxidation-Reduction, Peroxides, Phenols, Proteins

ID: 138280278