Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2
Research output: Contribution to journal › Journal article
The compound NS5806 increases the transient outward current (I(to)) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, I(to) is thought to be mediated by K(V)4.3 and various ancillary proteins, yet, the exact subunit composition of I(to) channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative I(to) channel subunits and other potassium channels.
|Journal||British Journal of Pharmacology|
|Number of pages||17|
|Publication status||Published - Aug 2010|
- Animals, CHO Cells, Cloning, Molecular, Cricetinae, Cricetulus, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Humans, Ion Channel Gating, Kinetics, Kv Channel-Interacting Proteins, Kv1.4 Potassium Channel, Membrane Potentials, Nerve Tissue Proteins, Phenylurea Compounds, Potassium, Potassium Channels, Potassium Channels, Voltage-Gated, Shal Potassium Channels, Tetrazoles, Transfection, Xenopus laevis