Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2

Research output: Contribution to journalJournal articleResearch

The compound NS5806 increases the transient outward current (I(to)) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, I(to) is thought to be mediated by K(V)4.3 and various ancillary proteins, yet, the exact subunit composition of I(to) channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative I(to) channel subunits and other potassium channels.
Original languageEnglish
JournalBritish Journal of Pharmacology
Issue number8
Pages (from-to)2028-44
Number of pages17
Publication statusPublished - Aug 2010

    Research areas

  • Animals, CHO Cells, Cloning, Molecular, Cricetinae, Cricetulus, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Humans, Ion Channel Gating, Kinetics, Kv Channel-Interacting Proteins, Kv1.4 Potassium Channel, Membrane Potentials, Nerve Tissue Proteins, Phenylurea Compounds, Potassium, Potassium Channels, Potassium Channels, Voltage-Gated, Shal Potassium Channels, Tetrazoles, Transfection, Xenopus laevis

ID: 32434189