Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2
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Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2. / Lundby, Alicia; Jespersen, Thomas; Schmitt, Nicole; Grunnet, Morten; Olesen, Søren-Peter; Cordeiro, Jonathan M; Calloe, Kirstine.
In: British Journal of Pharmacology, Vol. 160, No. 8, 08.2010, p. 2028-44.Research output: Contribution to journal › Journal article › Research
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TY - JOUR
T1 - Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2
AU - Lundby, Alicia
AU - Jespersen, Thomas
AU - Schmitt, Nicole
AU - Grunnet, Morten
AU - Olesen, Søren-Peter
AU - Cordeiro, Jonathan M
AU - Calloe, Kirstine
PY - 2010/8
Y1 - 2010/8
N2 - The compound NS5806 increases the transient outward current (I(to)) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, I(to) is thought to be mediated by K(V)4.3 and various ancillary proteins, yet, the exact subunit composition of I(to) channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative I(to) channel subunits and other potassium channels.
AB - The compound NS5806 increases the transient outward current (I(to)) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, I(to) is thought to be mediated by K(V)4.3 and various ancillary proteins, yet, the exact subunit composition of I(to) channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative I(to) channel subunits and other potassium channels.
KW - Animals
KW - CHO Cells
KW - Cloning, Molecular
KW - Cricetinae
KW - Cricetulus
KW - Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
KW - Humans
KW - Ion Channel Gating
KW - Kinetics
KW - Kv Channel-Interacting Proteins
KW - Kv1.4 Potassium Channel
KW - Membrane Potentials
KW - Nerve Tissue Proteins
KW - Phenylurea Compounds
KW - Potassium
KW - Potassium Channels
KW - Potassium Channels, Voltage-Gated
KW - Shal Potassium Channels
KW - Tetrazoles
KW - Transfection
KW - Xenopus laevis
U2 - 10.1111/j.1476-5381.2010.00859.x
DO - 10.1111/j.1476-5381.2010.00859.x
M3 - Journal article
C2 - 20649599
VL - 160
SP - 2028
EP - 2044
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 0007-1188
IS - 8
ER -
ID: 32434189