Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2

Research output: Contribution to journal › Journal article › Research

Standard

Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2. / Lundby, Alicia; Jespersen, Thomas; Schmitt, Nicole; Grunnet, Morten; Olesen, Søren-Peter; Cordeiro, Jonathan M; Calloe, Kirstine.

In: British Journal of Pharmacology, Vol. 160, No. 8, 08.2010, p. 2028-44.

Research output: Contribution to journal › Journal article › Research

Harvard

Lundby, A, Jespersen, T, Schmitt, N, Grunnet, M, Olesen, S-P, Cordeiro, JM & Calloe, K 2010, 'Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2', British Journal of Pharmacology, vol. 160, no. 8, pp. 2028-44. https://doi.org/10.1111/j.1476-5381.2010.00859.x

APA

Lundby, A., Jespersen, T., Schmitt, N., Grunnet, M., Olesen, S-P., Cordeiro, J. M., & Calloe, K. (2010). Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2. British Journal of Pharmacology, 160(8), 2028-44. https://doi.org/10.1111/j.1476-5381.2010.00859.x

Vancouver

Lundby A, Jespersen T, Schmitt N, Grunnet M, Olesen S-P, Cordeiro JM et al. Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2. British Journal of Pharmacology. 2010 Aug;160(8):2028-44. https://doi.org/10.1111/j.1476-5381.2010.00859.x

Author

Lundby, Alicia ; Jespersen, Thomas ; Schmitt, Nicole ; Grunnet, Morten ; Olesen, Søren-Peter ; Cordeiro, Jonathan M ; Calloe, Kirstine. / Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2. In: British Journal of Pharmacology. 2010 ; Vol. 160, No. 8. pp. 2028-44.

Bibtex

@article{b4e416049107427da0c0546cca0a2a4f,
title = "Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2",
abstract = "The compound NS5806 increases the transient outward current (I(to)) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, I(to) is thought to be mediated by K(V)4.3 and various ancillary proteins, yet, the exact subunit composition of I(to) channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative I(to) channel subunits and other potassium channels.",
keywords = "Animals, CHO Cells, Cloning, Molecular, Cricetinae, Cricetulus, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Humans, Ion Channel Gating, Kinetics, Kv Channel-Interacting Proteins, Kv1.4 Potassium Channel, Membrane Potentials, Nerve Tissue Proteins, Phenylurea Compounds, Potassium, Potassium Channels, Potassium Channels, Voltage-Gated, Shal Potassium Channels, Tetrazoles, Transfection, Xenopus laevis",
author = "Alicia Lundby and Thomas Jespersen and Nicole Schmitt and Morten Grunnet and S{\o}ren-Peter Olesen and Cordeiro, {Jonathan M} and Kirstine Calloe",
year = "2010",
month = aug,
doi = "10.1111/j.1476-5381.2010.00859.x",
language = "English",
volume = "160",
pages = "2028--44",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley",
number = "8",

}

RIS

TY - JOUR

T1 - Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2

AU - Lundby, Alicia

AU - Jespersen, Thomas

AU - Schmitt, Nicole

AU - Grunnet, Morten

AU - Olesen, Søren-Peter

AU - Cordeiro, Jonathan M

AU - Calloe, Kirstine

PY - 2010/8

Y1 - 2010/8

N2 - The compound NS5806 increases the transient outward current (I(to)) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, I(to) is thought to be mediated by K(V)4.3 and various ancillary proteins, yet, the exact subunit composition of I(to) channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative I(to) channel subunits and other potassium channels.

AB - The compound NS5806 increases the transient outward current (I(to)) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, I(to) is thought to be mediated by K(V)4.3 and various ancillary proteins, yet, the exact subunit composition of I(to) channels is still debated. Here we characterize the effect of NS5806 on heterologously expressed putative I(to) channel subunits and other potassium channels.

KW - Animals

KW - CHO Cells

KW - Cloning, Molecular

KW - Cricetinae

KW - Cricetulus

KW - Dipeptidyl-Peptidases and Tripeptidyl-Peptidases

KW - Humans

KW - Ion Channel Gating

KW - Kinetics

KW - Kv Channel-Interacting Proteins

KW - Kv1.4 Potassium Channel

KW - Membrane Potentials

KW - Nerve Tissue Proteins

KW - Phenylurea Compounds

KW - Potassium

KW - Potassium Channels

KW - Potassium Channels, Voltage-Gated

KW - Shal Potassium Channels

KW - Tetrazoles

KW - Transfection

KW - Xenopus laevis

U2 - 10.1111/j.1476-5381.2010.00859.x

DO - 10.1111/j.1476-5381.2010.00859.x

M3 - Journal article

C2 - 20649599

VL - 160

SP - 2028

EP - 2044

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 8

ER -

ID: 32434189