Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants

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Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants. / Benned-Jensen, Tau; Rosenkilde, M M.

In: British Journal of Pharmacology, Vol. 159, No. 5, 03.2010, p. 1092-105.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Benned-Jensen, T & Rosenkilde, MM 2010, 'Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants', British Journal of Pharmacology, vol. 159, no. 5, pp. 1092-105. https://doi.org/10.1111/j.1476-5381.2009.00633.x

APA

Benned-Jensen, T., & Rosenkilde, M. M. (2010). Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants. British Journal of Pharmacology, 159(5), 1092-105. https://doi.org/10.1111/j.1476-5381.2009.00633.x

Vancouver

Benned-Jensen T, Rosenkilde MM. Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants. British Journal of Pharmacology. 2010 Mar;159(5):1092-105. https://doi.org/10.1111/j.1476-5381.2009.00633.x

Author

Benned-Jensen, Tau ; Rosenkilde, M M. / Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants. In: British Journal of Pharmacology. 2010 ; Vol. 159, No. 5. pp. 1092-105.

Bibtex

@article{59dc40c6421948ad94c0fd5fe6f8680c,
title = "Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants",
abstract = "In humans and non-human primates, the 7TM receptor GPR17 exists in two isoforms differing only by the length of the N-terminus. Of these, only the short isoform has previously been characterized. Hence, we investigated gene expression and ligand-binding profiles of both splice variants and furthermore uncovered and characterized constitutive activity of both isoforms.",
keywords = "Binding, Competitive, Brain, Cell Line, Gene Expression, Humans, Kidney, Leukotrienes, Ligands, Myocardium, Protein Binding, Protein Isoforms, Receptors, G-Protein-Coupled, Reverse Transcriptase Polymerase Chain Reaction",
author = "Tau Benned-Jensen and Rosenkilde, {M M}",
year = "2010",
month = mar,
doi = "10.1111/j.1476-5381.2009.00633.x",
language = "English",
volume = "159",
pages = "1092--105",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley",
number = "5",

}

RIS

TY - JOUR

T1 - Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants

AU - Benned-Jensen, Tau

AU - Rosenkilde, M M

PY - 2010/3

Y1 - 2010/3

N2 - In humans and non-human primates, the 7TM receptor GPR17 exists in two isoforms differing only by the length of the N-terminus. Of these, only the short isoform has previously been characterized. Hence, we investigated gene expression and ligand-binding profiles of both splice variants and furthermore uncovered and characterized constitutive activity of both isoforms.

AB - In humans and non-human primates, the 7TM receptor GPR17 exists in two isoforms differing only by the length of the N-terminus. Of these, only the short isoform has previously been characterized. Hence, we investigated gene expression and ligand-binding profiles of both splice variants and furthermore uncovered and characterized constitutive activity of both isoforms.

KW - Binding, Competitive

KW - Brain

KW - Cell Line

KW - Gene Expression

KW - Humans

KW - Kidney

KW - Leukotrienes

KW - Ligands

KW - Myocardium

KW - Protein Binding

KW - Protein Isoforms

KW - Receptors, G-Protein-Coupled

KW - Reverse Transcriptase Polymerase Chain Reaction

U2 - 10.1111/j.1476-5381.2009.00633.x

DO - 10.1111/j.1476-5381.2009.00633.x

M3 - Journal article

C2 - 20148890

VL - 159

SP - 1092

EP - 1105

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 5

ER -

ID: 48317125