Characterization of oral and intravenous glucose handling in truncally vagotomised subjects with pyloroplasty

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OBJECTIVE: Glucagon-like peptide-1 (GLP-1) is rapidly inactivated by dipeptidyl peptidase 4, but may interact with vagal neurons at its site of secretion. We investigated the role of vagal innervation for handling of oral and iv glucose. Design and methods: Truncally vagotomised subjects (n=16) and matched controls (n=10) underwent 50g oral glucose tolerance test (OGTT)±vildagliptin, a DPP-4 inhibitor (DPP-4i) and isoglycaemic iv glucose infusion (IIGI) copying the OGTT without DPP-4i. Results: Isoglycaemia was obtained with 25±2 g glucose in vagotomised subjects and 18±2 g in controls (P
Original languageEnglish
JournalEuropean Journal of Endocrinology
Pages (from-to)187-201
Number of pages14
Publication statusPublished - 23 May 2013

ID: 45842367