Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans

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Caffeine (CAF) impedes insulin-mediated glucose disposal (IMGD) and increases plasma adrenaline concentrations ([ADR]; 0.6 nm). While the antagonism of ADR abolishes the CAF effect, infusion of ADR (0.75 nm) has no effect on IMGD. We have now examined CAF and ADR in concert to determine whether or not they elicit an additive response on IMGD. We hypothesized that CAF + ADR would elicit a greater effect than either CAF or ADR alone (i.e. that CAF effects would not be solely attributed to ADR). Subjects (n = 8) completed four trials in a randomized manner. An isoglycaemic-hyperinsulinaemic clamp was performed 30 min after the following treatments were administered: (1) placebo capsules and saline infusion ([ADR] = 0.29 nm) (PL trial), (2) CAF capsules (dose = 5 mg kg(-1)) and saline infusion ([ADR] = 0.62 nm) (CAF trial), (3) PL capsules and ADR infusion ([ADR] = 1.19 nm) (ADR trial), and (4) CAF capsules (dose = 5 mg kg(-1)) and ADR infusion ([ADR] = 0.93 nm) (CAF + ADR trial). As expected, CAF, ADR and CAF + ADR decreased (P
Original languageEnglish
JournalJournal of Physiology
Issue numberPt 3
Pages (from-to)1069-77
Number of pages8
Publication statusPublished - 2007

Bibliographical note

Keywords: Adult; Blood Glucose; Blood Pressure; Caffeine; Central Nervous System Stimulants; Drug Interactions; Epinephrine; Fatty Acids, Nonesterified; Heart Rate; Humans; Hyperinsulinism; Insulin; Male

ID: 12771939