Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans. / Battram, D S; Graham, T E; Dela, F.

In: Journal of Physiology, Vol. 583, No. Pt 3, 2007, p. 1069-77.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Battram, DS, Graham, TE & Dela, F 2007, 'Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans', Journal of Physiology, vol. 583, no. Pt 3, pp. 1069-77. https://doi.org/10.1113/jphysiol.2007.130526

APA

Battram, D. S., Graham, T. E., & Dela, F. (2007). Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans. Journal of Physiology, 583(Pt 3), 1069-77. https://doi.org/10.1113/jphysiol.2007.130526

Vancouver

Battram DS, Graham TE, Dela F. Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans. Journal of Physiology. 2007;583(Pt 3):1069-77. https://doi.org/10.1113/jphysiol.2007.130526

Author

Battram, D S ; Graham, T E ; Dela, F. / Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans. In: Journal of Physiology. 2007 ; Vol. 583, No. Pt 3. pp. 1069-77.

Bibtex

@article{c5e0b0105f2c11dea8de000ea68e967b,
title = "Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans",
abstract = "Caffeine (CAF) impedes insulin-mediated glucose disposal (IMGD) and increases plasma adrenaline concentrations ([ADR]; 0.6 nm). While the antagonism of ADR abolishes the CAF effect, infusion of ADR (0.75 nm) has no effect on IMGD. We have now examined CAF and ADR in concert to determine whether or not they elicit an additive response on IMGD. We hypothesized that CAF + ADR would elicit a greater effect than either CAF or ADR alone (i.e. that CAF effects would not be solely attributed to ADR). Subjects (n = 8) completed four trials in a randomized manner. An isoglycaemic-hyperinsulinaemic clamp was performed 30 min after the following treatments were administered: (1) placebo capsules and saline infusion ([ADR] = 0.29 nm) (PL trial), (2) CAF capsules (dose = 5 mg kg(-1)) and saline infusion ([ADR] = 0.62 nm) (CAF trial), (3) PL capsules and ADR infusion ([ADR] = 1.19 nm) (ADR trial), and (4) CAF capsules (dose = 5 mg kg(-1)) and ADR infusion ([ADR] = 0.93 nm) (CAF + ADR trial). As expected, CAF, ADR and CAF + ADR decreased (P",
author = "Battram, {D S} and Graham, {T E} and F Dela",
note = "Keywords: Adult; Blood Glucose; Blood Pressure; Caffeine; Central Nervous System Stimulants; Drug Interactions; Epinephrine; Fatty Acids, Nonesterified; Heart Rate; Humans; Hyperinsulinism; Insulin; Male",
year = "2007",
doi = "10.1113/jphysiol.2007.130526",
language = "English",
volume = "583",
pages = "1069--77",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "Pt 3",

}

RIS

TY - JOUR

T1 - Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans

AU - Battram, D S

AU - Graham, T E

AU - Dela, F

N1 - Keywords: Adult; Blood Glucose; Blood Pressure; Caffeine; Central Nervous System Stimulants; Drug Interactions; Epinephrine; Fatty Acids, Nonesterified; Heart Rate; Humans; Hyperinsulinism; Insulin; Male

PY - 2007

Y1 - 2007

N2 - Caffeine (CAF) impedes insulin-mediated glucose disposal (IMGD) and increases plasma adrenaline concentrations ([ADR]; 0.6 nm). While the antagonism of ADR abolishes the CAF effect, infusion of ADR (0.75 nm) has no effect on IMGD. We have now examined CAF and ADR in concert to determine whether or not they elicit an additive response on IMGD. We hypothesized that CAF + ADR would elicit a greater effect than either CAF or ADR alone (i.e. that CAF effects would not be solely attributed to ADR). Subjects (n = 8) completed four trials in a randomized manner. An isoglycaemic-hyperinsulinaemic clamp was performed 30 min after the following treatments were administered: (1) placebo capsules and saline infusion ([ADR] = 0.29 nm) (PL trial), (2) CAF capsules (dose = 5 mg kg(-1)) and saline infusion ([ADR] = 0.62 nm) (CAF trial), (3) PL capsules and ADR infusion ([ADR] = 1.19 nm) (ADR trial), and (4) CAF capsules (dose = 5 mg kg(-1)) and ADR infusion ([ADR] = 0.93 nm) (CAF + ADR trial). As expected, CAF, ADR and CAF + ADR decreased (P

AB - Caffeine (CAF) impedes insulin-mediated glucose disposal (IMGD) and increases plasma adrenaline concentrations ([ADR]; 0.6 nm). While the antagonism of ADR abolishes the CAF effect, infusion of ADR (0.75 nm) has no effect on IMGD. We have now examined CAF and ADR in concert to determine whether or not they elicit an additive response on IMGD. We hypothesized that CAF + ADR would elicit a greater effect than either CAF or ADR alone (i.e. that CAF effects would not be solely attributed to ADR). Subjects (n = 8) completed four trials in a randomized manner. An isoglycaemic-hyperinsulinaemic clamp was performed 30 min after the following treatments were administered: (1) placebo capsules and saline infusion ([ADR] = 0.29 nm) (PL trial), (2) CAF capsules (dose = 5 mg kg(-1)) and saline infusion ([ADR] = 0.62 nm) (CAF trial), (3) PL capsules and ADR infusion ([ADR] = 1.19 nm) (ADR trial), and (4) CAF capsules (dose = 5 mg kg(-1)) and ADR infusion ([ADR] = 0.93 nm) (CAF + ADR trial). As expected, CAF, ADR and CAF + ADR decreased (P

U2 - 10.1113/jphysiol.2007.130526

DO - 10.1113/jphysiol.2007.130526

M3 - Journal article

C2 - 17656440

VL - 583

SP - 1069

EP - 1077

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - Pt 3

ER -

ID: 12771939