Thomas Jespersen

Thomas Jespersen

Professor

Member of:


    1. Published

      hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics.

      Grunnet, Morten, Olesen, Søren-Peter, Klærke, Dan Arne & Jespersen, Thomas, 2005, In: Biochemical and Biophysical Research Communications. 328, 4, p. 1146-53 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    2. Published

      KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.

      Grunnet, Morten, Rasmussen, H. B., Hay-Schmidt, Anders, Rosenstierne, M., Klærke, Dan Arne, Olesen, Søren-Peter & Jespersen, Thomas, 2003, In: Biophysical Journal. 85, 3, p. 1525-37 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Characterization of two new dominant ClC-1 channel mutations associated with myotonia.

      Grunnet, Morten, Jespersen, Thomas, Colding-Jørgensen, E., Schwartz, M., Klærke, Dan Arne, Vissing, John, Olesen, Søren-Peter & Dunø, M., 2003, In: Muscle & Nerve. 28, 6, p. 722-32 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      Recruitment of motor neuronal persistent inward currents shapes withdrawal reflexes in the frog

      Grunnet, Morten, Jespersen, Thomas & Perrier, Jean-Francois Marie, 2004, In: Journal of Neuroscience Research. 78, p. 845-854

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      KCNE4 is an inhibitory subunit to the KCNQ1 channel.

      Grunnet, Morten, Jespersen, Thomas, Rasmussen, Hanne Borger, Ljungstrøm, T., Jorgensen, N. K., Olesen, Søren-Peter & Klærke, Dan Arne, 2002, In: Journal of Physiology. 542, Pt 1, p. 119-30 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      KCNQ1 channels sense small changes in cell volume.

      Grunnet, Morten, Jespersen, Thomas, MacAulay, Nanna, Jørgensen, N. K., Schmitt, Nicole, Pongs, O., Olesen, Søren-Peter & Klærke, Dan Arne, 2003, In: Journal of Physiology. 549, Pt 2, p. 419-27 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      5-HT1A receptors modulate small-conductance Ca2+-activated K+ channels.

      Grunnet, Morten, Jespersen, Thomas & Perrier, J., 2004, In: Journal of Neuroscience Research. 78, 6, p. 845-54 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Antiarrhythmic and electrophysiologic effects of flecainide on acutely induced atrial fibrillation in healthy horses

      Haugaard, M. M., Pehrson, S., Carstensen, Helena, Madsen, M. F., Hesselkilde, E. Z., Præstegaard, K. F., Diness, J. G., Grunnet, M., Jespersen, Thomas & Buhl, Rikke, 2015, In: Journal of Veterinary Internal Medicine. 29, 1, p. 339-347 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses

      Haugaard, M. M., Hesselkilde, E. Z., Pehrson, S. M., Carstensen, Helena, Madsen, M. F., Præstegaard, K. F., Sørensen, U. S., Diness, J. G., Grunnet, M., Buhl, Rikke & Jespersen, Thomas, Apr 2015, In: Heart rhythm : the official journal of the Heart Rhythm Society. 12, 4, p. 825-835 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Atrieflimmer og elektrofysiologi hos heste

      Haugaard, M. M., Buhl, Rikke & Jespersen, Thomas, 2011, In: Dansk Veterinaertidsskrift. 12, p. 28-31 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      The role of CAV3 in long-QT syndrome: clinical and functional assessment of a caveolin-3/Kv11.1 double heterozygote versus caveolin-3 single heterozygote

      Hedley, P. L., Kanters, Jørgen K., Dembic, M., Jespersen, Thomas, Skibsbye, L., Aidt, F. H., Eschen, O., Graff, C., Behr, E. R., Schlamowitz, S., Corfield, V., McKenna, W. J. & Christiansen, M., Oct 2013, In: Circulation: Cardiovascular Genetics. 6, 5, p. 452-61 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation

      Heijman, J., Zhou, X., Morotti, S., Molina, C. E., Abu-Taha, I. H., Tekook, M., Jespersen, Thomas, Zhang, Y., Dobrev, S., Milting, H., Gummert, J., Karck, M., Kamler, M., El-Armouche, A., Saljic, Arnela, Grandi, E., Nattel, S. & Dobrev, D., 2023, In: Circulation Research. 132, 9, p. E116-E133

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Published

      3D-electroanatomical mapping of the left atrium and catheter-based pulmonary vein isolation in pigs: A practical guide

      Hertel, Julie Norup, Jerltorp, K., Hansen, Malthe Emil Høtbjerg, Isaksen, Jonas L., Sattler, Stefan M, Linz, Benedikt Maximilian, Chaldoupi, S. M., Jespersen, Thomas, Saljic, Arnela, Gang, Uffe Jakob Ortved, Manninger, M. & Dr Linz, Dominik Karl, 2023, In: Frontiers in Cardiovascular Medicine. 10, 8 p., 1139364.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      First catheter-based high-density endocardial 3D electroanatomical mapping of the right atrium in standing horses

      Hesselkilde, E., Dr Linz, Dominik Karl, Saljic, Arnela, Carstensen, Helena, Kutieleh, R., Jespersen, Thomas, Sanders, P. & Buhl, Rikke, 2021, In: Equine Veterinary Journal. 53, 4, p. 186-193

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      A novel approach for obtaining 12-lead electrocardiograms in horses

      Hesselkilde, E. M., Isaksen, Jonas L., Petersen, B. V., Carstensen, Helena, Jespersen, Thomas, Pehrson, S., Kanters, Jørgen K. & Buhl, Rikke, 2021, In: Journal of Veterinary Internal Medicine. 35, 1, p. 521-531

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation

      Hesselkilde, E. Z., Carstensen, Helena, Haugaard, M. M., Carlson, J., Pehrson, S., Jespersen, Thomas, Buhl, Rikke & Platonov, P. G., Dec 2017, In: B M C Cardiovascular Disorders. 17, 6 p., 289.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Implantable loop recorders for arrhythmia detection - a new promising diagnostic tool for longterm arrhythmia monitoring

      Hesselkilde, E. Z., Carsten, H., Fenner, Merle Friederike, Jespersen, Thomas, T-felt, J., Sattler, Stefan M & Buhl, Rikke, 2019, In: Acta Physiologica. 227, S721, p. 93-93 35.

      Research output: Contribution to journalConference abstract in journalResearchpeer-review

    18. Published

      Longitudinal study of electrical, functional and structural remodelling in an equine model of atrial fibrillation

      Hesselkilde, E. Z., Carstensen, Helena, Flethøj, M., Fenner, Merle Friederike, Kruse, D. D., Sattler, Stefan M, Tfelt-Hansen, Jacob, Pehrson, S., Braunstein, T. H., Carlson, J., Platonov, P. G., Jespersen, Thomas & Buhl, Rikke, 2019, In: BMC Cardiovascular Disorders. 19, 1, 12 p., 228.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      O11 | In vitro and in vivo effects of dapagliflozin on adenosine diphosphate induced platelet aggregation response in Göttingen minipigs

      Hinz, K., Lyhne, Mille Kronborg, Debes, Karina Poulsdóttir, Reimann, Maria Josefine, Flethøj, M., Bruun, Camilla Vibeke Sichlau, Ludvigsen, Trine Pagh, Kirchhoff, J., Jespersen, Thomas, Pedersen, H. D., Møller, J. E. & Olsen, Lisbeth Høier, 2023, In: Journal of Veterinary Pharmacology and Therapeutics. 46, S1, p. 33 1 p., O11.

      Research output: Contribution to journalConference abstract in journalResearchpeer-review

    20. Published

      Electrophysiologic effects of the IK1 inhibitor PA-6 are modulated by extracellular potassium in isolated guinea pig hearts

      Hoeker, G. S., Skarsfeldt, M. A., Jespersen, Thomas & Poelzing, S., Jan 2017, In: Physiological Reports. 5, 1, 10 p., e13120.

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      Does KCNE5 play a role in long QT syndrome?

      Hofman-Bang, J., Jespersen, Thomas, Grunnet, Morten, Larsen, Lars Allan, Andersen, P. S., Kanters, Jørgen K., Kjeldsen, K. & Christiansen, M., 2004, In: Clinica Chimica Acta. 345, 1-2, p. 49-53 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Sick sinus syndrome, progressive cardiac conduction disease, atrial flutter and ventricular tachycardia caused by a novel SCN5A mutation

      Holst, A. G., Liang, B., Jespersen, Thomas, Bundgård, Henning, Haunso, S., Svendsen, Jesper Hastrup & Tfelt-Hansen, J., 2010, In: Cardiology. 115, 4, p. 311-6 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      A Novel SCN5A Mutation in a Patient with Coexistence of Brugada Syndrome Traits and Ischaemic Heart Disease

      Holst, A. G., Callø, Kirstine, Jespersen, Thomas, Cedergreen, P., Winkel, B. G., Jensen, H. K., Leren, T. P., Haunso, S., Svendsen, Jesper Hastrup & Tfelt-Hansen, J., 2009, In: Case Reports in Medicine. 2009, p. 963645

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      Functionally Selective AT(1) Receptor Activation Reduces Ischemia Reperfusion Injury

      Hostrup, A., Christensen, G. L., Bentzen, Bo Hjorth, Liang, B., Aplin, M., Grunnet, Morten, Hansen, J. L. & Jespersen, Thomas, 30 Jul 2012, In: Cellular Physiology and Biochemistry. 30, 3, p. 642-652 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      Pharmacological blockade of small conductance Ca-activated K channels by ICA reduces arrhythmic load in rats with acute myocardial infarction

      Hundahl, L. A., Sattler, S. M., Skibsbye, L., Diness, J. G., Tfelt-Hansen, Jacob & Jespersen, Thomas, Jun 2017, In: Pflügers Archiv - European Journal of Physiology. 469, 5-6, p. 739-750 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction

      Hundahl, L. A., Tfelt-Hansen, Jacob & Jespersen, Thomas, Nov 2017, In: Journal of Cardiovascular Pharmacology and Therapeutics. 22, 6, p. 514-528 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Published
    28. Published

      Regulation of APD and Force by the Na+/Ca2+ Exchanger in Human-Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue

      Ismaili, D., Gurr, K., Horvath, A., Yuan, L., Lemoine, M. D., Schulz, C., Sani, J., Petersen, J., Reichenspurner, H., Kirchhof, P., Jespersen, Thomas, Eschenhagen, T., Hansen, A., Koivumaeki, J. T. & Christ, T., 2022, In: Cells. 11, 15, 15 p., 2424.

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. Published

      Common and rare variants in SCN10A modulate the risk of atrial fibrillation.

      Jabbari, J., Olesen, Morten Steen Salling, Yuan, L., Nielsen, J. B., Liang, B., Macri, V., Christophersen, I. E., Nielsen, N., Sajadieh, Ahmad, Ellinor, P. T., Grunnet, Morten, Haunsø, Stig, Holst, A. G., Svendsen, Jesper Hastrup & Jespersen, Thomas, 2015, In: Circulation: Cardiovascular Genetics. 8, 1, p. 64-73 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Published

      The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes.

      Jensen, H. S., Callø, Kirstine, Jespersen, Thomas, Jensen, B. S. & Olesen, Søren-Peter, 2005, In: Brain Research. 139, 1, p. 52-62 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published

      Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes

      Jespersen, Thomas, Grunnet, Morten, Angelo, K., Klærke, Dan Arne & Olesen, Poul, 1 Mar 2002, In: BioTechniques. 32, 3, p. 536-8, 540

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published
    33. Published

      Expression of heterologous genes from an IRES translational cassette in replication competent murine leukemia virus vectors

      Jespersen, Thomas, Duch, M. R., Carrasco, M. L., Warming, S. & Pedersen, F. S., 1 Nov 1999, In: Gene. 239, 2, p. 227-35 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Published

      Efficient non-PCR-mediated overlap extension of PCR fragments by exonuclease "end polishing"

      Jespersen, Thomas, Duch, M. R. & Pedersen, F. S., 1 Jul 1997, In: BioTechniques. 23, 1, p. 48, 50, 52

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Published

      The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.

      Jespersen, Thomas, Membrez, M., Nicolas, C. S., Pitard, B., Staub, O., Olesen, Søren-Peter, Baró, I. & Abriel, H., 2007, In: Cardiovascular Research. 74, 1, p. 64-74 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published

      Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1.

      Jespersen, Thomas, Gavillet, B., van Bemmelen, M. X., Cordonier, S., Thomas, M. A., Staub, O. & Abriel, H., 2006, In: Biochemical and Biophysical Research Communications. 348, 4, p. 1455-62 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    37. Published

      The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?

      Jespersen, Thomas, Grunnet, Morten, Rasmussen, Hanne Borger, Jørgensen, N. B., Jensen, H., Angelo, K., Olesen, Søren-Peter & Klærke, Dan Arne, 2006, In: Biochemical and Biophysical Research Communications. 341, 4, p. 979-88 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    38. Published

      Regulation and physiological function of Na(v) 1.5 and KCNQ1 channels

      Jespersen, Thomas, 2011, In: Acta Physiologica (Print). 202 Suppl 683, p. 1-26 26 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Published

      Kondo physics in tunable semicondouctor nanowire quantum dots

      Jespersen, Thomas, Aagesen, M., Sørensen, Claus Birger, Lindelof, Poul Erik & Nygård, Jesper, 2006, In: Physical Review B. Condensed Matter and Materials Physics. 74, 23, p. 233304

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Cardiac Arrhythmia - new considerations: The Cardiac Ion Channels

      Jespersen, Thomas, 29 Feb 2012, Cardiac Arrhythmias - new considerations. Breijo-Marquez, F. R. (ed.). Croatia: InTech, p. 45-72 29 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    41. Published

      Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif.

      Jespersen, Thomas, Rasmussen, Hanne Borger, Grunnet, Morten, Jensen, H. S., Angelo, K., Dupuis, D. S., Vogel, L. K., Jorgensen, N. K., Klærke, Dan Arne & Olesen, Søren-Peter, 2004, In: Journal of Cell Science. 117, Pt 19, p. 4517-26 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published

      The KCNQ1 potassium channel: from gene to physiological function.

      Jespersen, Thomas, Grunnet, Morten & Olesen, Søren-Peter, 2005, In: Physiology. 20, p. 408-16 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    43. Published

      Effect of Selective IK,ACh Inhibition by XAF-1407 in an Equine Model of Tachypacing-induced Persistent Atrial Fibrillation (AF)

      Jespersen, Thomas, Fenner, Merle Friederike & Buhl, Rikke, 2019, In: Acta Physiologica. 227, S721, p. 96-96

      Research output: Contribution to journalConference abstract in journalResearchpeer-review

    44. Published

      Urinary markers of nucleic acid oxidation increase with age, obesity and insulin resistance in Danish children and adolescents

      Jors, A., Lund, M. A. ,. V., Jespersen, Thomas, Hansen, Torben, Poulsen, Henrik Enghusen & Holm, Jens-Christian, 2020, In: Free Radical Biology and Medicine. 155, p. 81-86

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      Double mutation at the putative protein kinase C phosphorylation sites Thr151 plus Thr323 in the mouse leukotrieneD4 receptor eliminates homologous desensitization

      Jørgensen, S. T., Eriksen, H. N., Dausell, J., Jespersen, Thomas, Lambert, Ian Henry & Hoffmann, E. K., 2013, In: Cellular Physiology and Biochemistry. 31, 2-3, p. 366-378 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    46. Published

      Flecainide provocation reveals concealed brugada syndrome in a long QT syndrome family with a novel L1786Q mutation in SCN5A. SCN5A mutations associated with overlap phenotype of long QT syndrome type 3 and Brugada syndrome.

      Kanters, Jørgen K., Yuan, L., Hedley, P. L., Stoevring, B., Jons, C., Bloch Thomsen, P. E., Grunnet, Morten, Christiansen, M. & Jespersen, Thomas, 6 Mar 2014, In: Circulation Journal. 78, 5, p. 1136-43 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Combined gating and trafficking defect in Kv11.1 manifests as a malignant long QT syndrome phenotype in a large Danish p.F29L founder family

      Kanters, Jørgen K., Skibsbye, L., Hedley, P. L., Dembic, M., Liang, B., Hagen, C. M., Eschen, O., Grunnet, Morten, Christiansen, M. & Jespersen, Thomas, 2015, In: Scandinavian Journal of Clinical & Laboratory Investigation. 75, 8, p. 699-709 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      Antiarrhythmic effect of the Ca(2+)-activated K(+) (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation

      Kirchhoff, J. E., Diness, Jonas Goldin, Abildgaard, L., Sheykhzade, Majid, Grunnet, Morten & Jespersen, Thomas, 8 Oct 2016, In: Pfluegers Archiv. 468, 11, p. 1853–1863 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    49. Published

      The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts

      Kirchhoff, J. E., Skarsfeldt, M., Muthukumarasamy, K. M., Simó-Vicens, R., Bomholtz, Sofia Hammami, Abildgaard, L., Jespersen, Thomas, Sørensen, U. S., Grunnet, Morten, Bentzen, Bo Hjorth & Diness, Jonas Goldin, 2019, In: Frontiers in Pharmacology. 10, 13 p., 668.

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Published

      Synergistic antiarrhythmic effect of combining inhibition of Ca(2+)-activated K(+) (SK) channels and voltage-gated Na(+) channels in an isolated heart model of atrial fibrillation

      Kirchhoff, J. E., Goldin Diness, J., Sheykhzade, Majid, Grunnet, M. & Jespersen, Thomas, Feb 2015, In: Heart rhythm : the official journal of the Heart Rhythm Society. 12, 2, p. 409-18 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    ID: 8117