Julien Ochala
Associate Professor - Promotion Programme
- Published
NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy
Ranu, N., Laitila, J., Dugdale, H. F., Mariano, J., Kolb, J. S., Wallgren-Pettersson, C., Witting, N., Vissing, J., Vilchez, J. J., Fiorillo, C., Zanoteli, E., Auranen, M., Jokela, M., Tasca, G., Claeys, K. G., Voermans, N. C., Palmio, J., Huovinen, S., Moggio, M., Beck, T. N. & 3 others, , 2022, In: Acta Neuropathologica Communications. 10, 185.Research output: Contribution to journal › Journal article › Research › peer-review
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A Laing distal myopathy-associated proline substitution in the β-myosin rod perturbs myosin cross-bridging activity
Buvoli, M., Wilson, G. C., Buvoli, A., Gugel, J. F., Hau, A., Bönnemann, C. G., Paradas, C., Ryba, D. M., Woulfe, K. C., Walker, L. A., Buvoli, T., Ochala, Julien & Leinwand, L. A., 2024, In: The Journal of Clinical Investigation. 134, 9, 16 p., :e172599.Research output: Contribution to journal › Journal article › Research › peer-review
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A myopathy-linked tropomyosin mutation severely alters thin filament conformational changes during activation
Ochala, Julien, Iwamoto, H., Larsson, L. & Yagi, N., 25 May 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 21, p. 9807-12 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A myopathy-related actin mutation increases contractile function
Lindqvist, J., Pénisson-Besnier, I., Iwamoto, H., Li, M., Yagi, N. & Ochala, Julien, May 2012, In: Acta Neuropathologica. 123, 5, p. 739-746 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A rational approach to selective targeting of skeletal myosin
Katarina Antonovic, A., Ochala, Julien & Fornili, A., 2023, In: Biophysical Journal. 122, 3S1, p. 117aResearch output: Contribution to journal › Journal article › Research › peer-review
Aberrant post-translational modifications compromise human myosin motor function in old age
Li, M., Ogilvie, H., Ochala, Julien, Artemenko, K., Iwamoto, H., Yagi, N., Bergquist, J. & Larsson, L., Apr 2015, In: Aging Cell. 14, 2, p. 228-35 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Abnormal myosin post-translational modifications and ATP turnover time associated with human congenital myopathy-related RYR1 mutations
Sonne, A., Antonovic, A. K., Thomsen, Elise Julie Melhedegaard, Akter, F., Andersen, J. L., Jungbluth, H., Witting, N., Vissing, John, Zanoteli, E., Fornili, A. & Ochala, Julien, 2023, In: Acta Physiologica. 239, 2, 14 p., e14035.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity
Crombie, E. M., Kim, S., Adamson, S., Dong, H., Lu, T. C., Wu, Y., Wu, Y., Levy, Y., Stimple, N., Lam, W. M. R., Hey, H. W. D., Withers, D. J., Hsu, A. L., Bay, B. H., Ochala, Julien & Tsai, S. Y., 2023, In: Journal of Cachexia, Sarcopenia and Muscle. 14, p. 198–213Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Binding pocket dynamics along the recovery stroke of human β-cardiac myosin
Akter, F., Ochala, Julien & Fornili, A., 2023, In: PLOS Computational Biology. 19, 5, 14 p., e1011099.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ca2+ sensitizers: An emerging class of agents for counterbalancing weakness in skeletal muscle diseases?
Ochala, Julien, Feb 2010, In: Neuromuscular Disorders. 20, 2, p. 98-101 4 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle
Negoita, F., Addinsall, A. B., Hellberg, K., Bringas, C. F., Hafen, P. S., Sermersheim, T. J., Agerholm, M., Lewis, C. T. A., Ahwazi, D., Ling, N. X. Y., Larsen, J. K., Deshmukh, A. S., Hossain, M. A., Oakhill, J. S., Ochala, J., Brault, J. J., Sankar, U., Drewry, D. H., Scott, J. W., Witczak, C. A. & 1 others, , 2023, In: Molecular Metabolism. 75, 14 p., 101761.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Can we talk about myoblast fusion?
Dugdale, H. F. & Ochala, Julien, 2021, In: American Journal of Physiology - Cell Physiology. 321, 3, p. C504-C506Research output: Contribution to journal › Review › Research › peer-review
Candidate gene expression and coding sequence variants in Warmblood horses with myofibrillar myopathy
Williams, Z. J., Velez-Irizarry, D., Petersen, J. L., Ochala, Julien, Finno, C. J. & Valberg, S. J., 2020, (Accepted/In press) In: Equine Veterinary Journal.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in mechanical properties of human plantar flexor muscles in ageing
Ochala, Julien, Lambertz, D., Pousson, M., Goubel, F. & Van Hoecke, J., Mar 2004, In: Experimental Gerontology. 39, 3, p. 349-358 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in muscle and joint elasticity following long-term strength training in old age
Ochala, Julien, Lambertz, D., Hoecke, J. & Pousson, M., Jul 2007, In: European Journal of Applied Physiology. 100, 5, p. 491-498 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparative study of binding pocket structure and dynamics in cardiac and skeletal myosin
Antonovic, A. K., Ochala, Julien & Fornili, A., 2023, In: Biophysical Journal. 122, 1, p. 54-62Research output: Contribution to journal › Journal article › Research › peer-review
Congenital myopathies: disorders of excitation-contraction coupling and muscle contraction
Jungbluth, H., Treves, S., Zorzato, F., Sarkozy, A., Ochala, Julien, Sewry, C., Phadke, R., Gautel, M. & Muntoni, F., Mar 2018, In: Nature Reviews. Neurology. 14, 3, p. 151-167 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms
Ochala, Julien, Gokhin, D. S., Pénisson-Besnier, I., Quijano-Roy, S., Monnier, N., Lunardi, J., Romero, N. B. & Fowler, V. M., Oct 2012, In: Human Molecular Genetics. 21, 20, p. 4473-4485 13 p., dds289.Research output: Contribution to journal › Journal article › Research › peer-review
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Correction: Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle (PLoS ONE)
Joanne, P., Hourdé, C., Ochala, Julien, Caudéran, Y., Medja, F., Vignaud, A., Mouisel, E., Hadj-Said, W., Arandel, L., Garcia, L., Goyenvalle, A., Mounier, R., Zibroba, D., Sakamato, K., Butler-Browne, G., Agbulut, O. & Ferry, A., 27 Jun 2013, In: PLoS ONE. 8, 6Research output: Contribution to journal › Comment/debate › Research › peer-review
Current and future therapeutic approaches to the congenital myopathies
Jungbluth, H., Ochala, Julien, Treves, S. & Gautel, M., Apr 2017, In: Seminars in Cell and Developmental Biology. 64, p. 191-200 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Defective regulation of contractile function in muscle fibres carrying an E41K β-tropomyosin mutation
Ochala, Julien, Li, M., Ohlsson, M., Oldfors, A. & Larsson, L., 15 Jun 2008, In: Journal of Physiology. 586, 12, p. 2993-3004 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action
Svensson, K., Dent, J. R., Tahvilian, S., Martins, V. F., Sathe, A., Ochala, Julien, Patel, M. S. & Schenk, S., Nov 2018, In: American Journal of Physiology - Endocrinology and Metabolism. 315, 5, p. E1034-E1045Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Diaphragm muscle weakness in an experimental porcine intensive care unit model
Ochala, Julien, Renaud, G., Diez, M. L., Banduseela, V. C., Aare, S., Ahlbeck, K., Radell, P. J., Eriksson, L. I. & Larsson, L., 2011, In: PLoS ONE. 6, 6, e20558.Research output: Contribution to journal › Journal article › Research › peer-review
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Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy
Ochala, Julien, Lehtokari, V. L., Iwamoto, H., Li, M., Feng, H. Z., Jin, J. P., Yagi, N., Wallgren-Pettersson, C., Pénisson-Besnier, I. & Larsson, L., Jun 2011, In: FASEB Journal. 25, 6, p. 1903-1913 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct underlying mechanisms of limb and respiratory muscle fiber weaknesses in nemaline myopathy
Lindqvist, J., Cheng, A. J., Renaud, G., Hardeman, E. C. & Ochala, Julien, Jun 2013, In: Journal of Neuropathology and Experimental Neurology. 72, 6, p. 472-481 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle
Roy, P., Rau, F., Ochala, Julien, Messéant, J., Fraysse, B., Lainé, J., Agbulut, O., Butler-Browne, G., Furling, D. & Ferry, A., 20 Jul 2016, In: Skeletal Muscle. 6, 1, 23.Research output: Contribution to journal › Journal article › Research › peer-review
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EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation
Ochala, Julien, Radell, P. J., Eriksson, L. I. & Larsson, L., Feb 2010, In: Pflugers Archiv European Journal of Physiology. 459, 3, p. 475-483 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Early clinical and pre-clinical therapy development in Nemaline myopathy
Fisher, G., Mackels, L., Markati, T., Sarkozy, A., Ochala, Julien, Jungbluth, H., Ramdas, S. & Servais, L., 28 Dec 2022, In: Expert Opinion On Therapeutic Targets. 26, 10, p. 853–867Research output: Contribution to journal › Review › Research › peer-review
Effect of PGC1-beta ablation on myonuclear organisation
Beedour, R., Ross, J. A., Levy, Y. & Ochala, Julien, 1 Dec 2019, In: Journal of Muscle Research and Cell Motility. 40, 3-4, p. 335-341 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of strength training on musculotendinous stiffness in elderly individuals
Ochala, Julien, Lambertz, D., Van Hoecke, J. & Pousson, M., May 2005, In: European Journal of Applied Physiology. 94, 1-2, p. 126-133 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of a R133W β-tropomyosin mutation on regulation of muscle contraction in single human muscle fibres
Ochala, Julien, Li, M., Tajsharghi, H., Kimber, E., Tulinius, M., Oldfors, A. & Larsson, L., 1 Jun 2007, In: Journal of Physiology. 581, 3, p. 1283-1292 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres
Ochala, Julien & Larsson, L., Apr 2008, In: Experimental Physiology. 93, 4, p. 486-495 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres
Ross, J. A., Pearson, A., Levy, Y., Cardel, B., Handschin, C. & Ochala, Julien, 1 Jun 2017, In: Journal of Cellular Physiology. 232, 6, p. 1270-1274 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Factors underlying the early limb muscle weakness in acute quadriplegic myopathy using an experimental ICU porcine model
Ochala, Julien, Ahlbeck, K., Radell, P. J., Eriksson, L. I. & Larsson, L., 2011, In: PLoS ONE. 6, 6, e20876.Research output: Contribution to journal › Journal article › Research › peer-review
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Fine-regulation of myosin relaxed states in vertebrate muscle
Thomsen, Elise Julie Melhedegaard, Sonne, A., Bertelsen, Mads Frost, Vermeulen, E., Ganswindt, A., Wang, T. & Ochala, Julien, 2022, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36Research output: Contribution to journal › Journal article › Research › peer-review
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Gender differences in human muscle and joint mechanical properties during plantar flexion in old age
Ochala, Julien, Valour, D., Pousson, M., Lambertz, D. & Van Hoecke, J., May 2004, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 59, 5, p. 441-448 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gene expression and muscle fiber function in a porcine ICU model
Banduseela, V. C., Ochala, Julien, Chen, Y. W., Göransson, H., Norman, H., Radell, P., Eriksson, L. I., Hoffman, E. P. & Larsson, L., Nov 2009, In: Physiological Genomics. 39, 3, p. 141-159 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Human skeletal myopathy myosin mutations disrupt myosin head sequestration
Carrington, G., Hau, A., Kosta, S., Dugdale, H. F., Muntoni, F., D’Amico, A., Van den Bergh, P., Romero, N. B., Malfatti, E., Vilchez, J. J., Oldfors, A., Pajusalu, S., Õunap, K., Giralt-Pujol, M., Zanoteli, E., Campbell, K. S., Iwamoto, H., Peckham, M. & Ochala, Julien, 2023, In: JCI insight. 8, 21, p. 1-19 e172322.Research output: Contribution to journal › Journal article › Research › peer-review
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Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy
Ross, J. A., Levy, Y., Ripolone, M., Kolb, J. S., Turmaine, M., Holt, M., Lindqvist, J., Claeys, K. G., Weis, J., Monforte, M., Tasca, G., Moggio, M., Figeac, N., Zammit, P. S., Jungbluth, H., Fiorillo, C., Vissing, J., Witting, N., Granzier, H., Zanoteli, E. & 3 others, , 2019, In: Acta Neuropathologica. 138, 3, p. 477-495 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Maintenance of muscle mass, fiber size, and contractile function in mice lacking the Z-disc protein myotilin
Ochala, Julien, Carpn, O. & Larsson, L., 2009, In: Upsala Journal of Medical Sciences. 114, 4, p. 235-241 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms underlying the sparing of masticatory versus limb muscle function in an experimental critical illness model
Aare, S., Ochala, Julien, Norman, H. S., Radell, P., Eriksson, L. I., Göransson, H., Chen, Y. W., Hoffman, E. P. & Larsson, L., Dec 2011, In: Physiological Genomics. 43, 24, p. 1334-1350 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Methodological considerations in measuring specific force in human single skinned muscle fibres
Kalakoutis, M., Di Giulio, I., Douiri, A., Ochala, Julien, Harridge, S. D. R. & Woledge, R. C., 2021, In: Acta Physiologica. 233, 3, p. 1-18 e13719.Research output: Contribution to journal › Review › Research › peer-review
Modulating myosin restores muscle function in a mouse model of nemaline myopathy
Lindqvist, J., Levy, Y., Pati-Alam, A., Hardeman, E. C., Gregorevic, P. & Ochala, Julien, 1 May 2016, In: Annals of Neurology. 79, 5, p. 717-725 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Molecular consequences of the myopathy-related D286G mutation on actin function
Fan, J., Chan, C., McNamara, E. L., Nowak, K. J., Iwamoto, H. & Ochala, Julien, 1 Dec 2018, In: Frontiers in Physiology. 9, 1756.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Muscle fibre size and myonuclear positioning in trained and aged humans
Battey, E., Levy, Y., Pollock, R. D., Pugh, J. N., Close, G. L., Kalakoutis, M., Lazarus, N. R., Harridge, S. D. R., Ochala, Julien & Stroud, M. J., 2024, (E-pub ahead of print) In: Experimental Physiology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Muscle paralysis and myosin loss in a patient with cancer cachexia
Banduseela, V., Ochala, Julien, Lamberg, K., Kalimo, H. & Larsson, L., Dec 2007, In: Acta Myologica. 26, 3, p. 136-144 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Myofibre hyper-contractility in horses expressing the myosin heavy chain myopathy mutation, myh1e321g
Ochala, Julien, Finno, C. J. & Valberg, S. J., 2021, In: Cells. 10, 12, 3428.Research output: Contribution to journal › Journal article › Research › peer-review
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Myofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIb
Kurapati, R., McKenna, C., Lindqvist, J., Williams, D., Simon, M., LeProust, E., Baker, J., Cheeseman, M., Carroll, N., Denny, P., Laval, S., Lochmüller, H., Ochala, Julien & Blanco, G., Apr 2012, In: Human Molecular Genetics. 21, 8, p. 1706-1724 19 p., ddr605.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Myofilament lattice structure in presence of a skeletal myopathy-related tropomyosin mutation
Ochala, Julien & Iwamoto, H., Aug 2013, In: Journal of Muscle Research and Cell Motility. 34, 3-4, p. 171-175 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Myonuclear alterations associated with exercise are independent of age in humans
Battey, E., Ross, J. A., Hoang, A., Wilson, D. G. S., Han, Y., Levy, Y., Pollock, R. D., Kalakoutis, M., Pugh, J. N., Close, G. L., Ellison-Hughes, G. M., Lazarus, N. R., Iskratsch, T., Harridge, S. D. R., Ochala, Julien & Stroud, M. J., 2024, (E-pub ahead of print) In: Journal of Physiology.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 240294914
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Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy
Research output: Contribution to journal › Journal article › Research › peer-review
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59
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Myofibre hyper-contractility in horses expressing the myosin heavy chain myopathy mutation, myh1e321g
Research output: Contribution to journal › Journal article › Research › peer-review
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Using nuclear envelope mutations to explore age-related skeletal muscle weakness
Research output: Contribution to journal › Journal article › Research › peer-review
Published