Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
- 2011
- Published
Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test
Møller, J. B., Jusko, W. J., Gao, W., Hansen, Torben, Pedersen, Oluf Borbye, Holst, Jens Juul, Overgaard, R. V., Madsen, H. & Ingwersen, S. H., 2011, In: Journal of Pharmacokinetics and Pharmacodynamics. 38, 6, p. 713-25 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neuroprotective properties of GLP-1: theoretical and practical applications
Holst, Jens Juul, Burcelin, R. & Nathanson, E., 2011, In: Current Medical Research and Opinion. 27, 3, p. 547-58 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Obesity - an indication for GLP-1 treatment? Obesity pathophysiology and GLP-1 treatment potential
Torekov, Signe Sørensen, Madsbad, Sten & Holst, Jens Juul, 2011, In: Obesity Reviews. 12, 8, p. 593-601 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protein dose-response effect on glp-1, pyy and appetite in male subjects
Sparre, A. B., Sørensen, M. Q., Holst, Jens Juul, Rehfeld, Jens Frederik & Astrup, A., 2011, In: Obesity Reviews. 12, suppl. 1, p. 59 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans
Nauck, M. A., Kemmeries, G., Holst, Jens Juul & Meier, J. J., 2011, In: Diabetes. 60, 5, p. 1561-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?
Nauck, M. A., Vardarli, I., Deacon, Carolyn F., Holst, Jens Juul & Meier, J., 2011, In: Diabetologia. 54, 1, p. 10-18 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of Glucagon-Like Peptide-2 on mesenteric blood flow and cardiac parameters in end-jejunostomy short bowel patients
Bremholm, L., Hornum, Mads, Andersen, U. B., Hartmann, Bolette, Holst, Jens Juul & Jeppesen, Palle Bekker, 2011, In: Regulatory Peptides. 168, 1-3, p. 32-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of dietary fish oil in addition to lifestyle counselling on lipid oxidation and body composition in slightly overweight teenage boys
Pedersen, M. H., Mølgaard, Christian, Hellgren, L., Matthiessen, J., Holst, Jens Juul & Lauritzen, Lotte, 2011, In: Journal of Nutrition and Metabolism. 2011, 348368, 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effects of L-arabinose on intestinal sucrase activity: dose-response studies in vitro and in humans
Krog-Mikkelsen, I., Hels, O., Tetens, Inge , Holst, Jens Juul, Andersen, Jens Rikardt & Bukhave, K., 2011, In: American Journal of Clinical Nutrition. 94, 2, p. 472-478 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes
Lund, Asger Bach, Vilsbøll, Tina, Bagger, J. I., Holst, Jens Juul & Knop, Filip Krag, 2011, In: American Journal of Physiology: Endocrinology and Metabolism. 300, 6, p. E1038-E1046 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus--an adaptive response to hyperglycaemia?
Hansen, A. M. K., Bödvarsdottir, T. B., Nordestgaard, D. N. E., Heller, Rasmus, Gotfredsen, C. F., Maedler, K., Fels, J., Holst, Jens Juul & Karlsen, A., 2011, In: Diabetologia. 54, 6, p. 1379-87 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Women with bulimia nervosa exhibit attenuated secretion of glucagon-like peptide 1, pancreatic polypeptide, and insulin in response to a meal
Naessén, S., Carlström, K., Holst, Jens Juul, Hellström, P. M. & Hirschberg, A. L., 2011, In: American Journal of Clinical Nutrition. 94, 4, p. 967-972 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Treatment of insulin resistance and obesity by stimulating GLP-1 release
Hansen, Harald S., Diep, T. A., Holst, Jens Juul, Rosenkilde, Mette & Andersen, N. W., 29 Dec 2010, IPC No. A61K 31/23, Patent No. PCT/DK2010/050161, 24 Jun 2010Research output: Patent
- Published
Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1
Migoya, E. M., Bergeron, R., Miller, J. L., Snyder, R. N. K., Tanen, M., Hilliard, D., Weiss, B., Larson, P., Gutierrez, M., Jiang, G., Liu, F., Pryor, K. A., Yao, J., Zhu, L., Holst, J. J., Deacon, C., Herman, G., Thornberry, N., Amatruda, J., Williams-Herman, D. & 2 others, , 1 Dec 2010, In: Clinical Pharmacology and Therapeutics. 88, 6, p. 801-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sustained glucagon-like peptide-2 infusion is required for intestinal adaptation, and cessation reverses increased cellularity in rats with intestinal failure
Koopmann, M. C., Chen, X., Holst, Jens Juul & Ney, D. M., 1 Dec 2010, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 299, 6, p. G1222-30 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A cereal-based evening meal rich in indigestible carbohydrates increases plasma butyrate the next morning
Nilsson, A. C., Östman, E. M., Knudsen, K. E. B., Holst, Jens Juul & Björck, I. M. E., 1 Nov 2010, In: Journal of Nutrition. 140, 11, p. 1932-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis
Edholm, T., Degerblad, M., Grybäck, P., Hilsted, Linda, Holst, Jens Juul, Jacobsson, H., Efendic, S., Schmidt, P. T. & Hellström, P. M., 1 Nov 2010, In: Neurogastroenterology and Motility Online. 22, 11, p. 1191-200, e315 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kardiale virkninger af glukagonlignende peptid 1
Holst, Jens Juul, 11 Oct 2010, In: Ugeskrift for Laeger. 172, 41, p. 2821 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of mRNA for proglucagon and glucagon-like peptide-2 (GLP-2) receptor in the ruminant gastrointestinal tract and the influence of energy intake
Taylor-Edwards, C. C., Burrin, D. G., Matthews, J. C., McLeod, K. R., Holst, Jens Juul & Harmon, D. L., 1 Oct 2010, In: Domestic Animal Endocrinology. 39, 3, p. 181-93 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The intestinotrophic peptide, GLP-2, counteracts the gastrointestinal atrophy in mice induced by the epidermal growth factor receptor inhibitor, erlotinib, and cisplatin
Rasmussen, A. R., Viby, N., Hare, K. J., Hartmann, Bolette, Thim, L., Holst, Jens Juul & Poulsen, Steen Seier, 1 Oct 2010, In: Digestive Diseases and Sciences. 55, 10, p. 2785-96 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon suppression during OGTT worsens while suppression during IVGTT sustains alongside development of glucose intolerance in patients with chronic pancreatitis
Knop, Filip Krag, Vilsbøll, Tina, Larsen, S., Madsbad, Sten, Holst, Jens Juul & Krarup, T. M., 24 Sep 2010, In: Regulatory Peptides. 164, 2-3, p. 144-50 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The impact of pancreatic enzyme supplementation on postprandial responses of glucagon-like Peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency
Knop, Filip Krag, Vilsbøll, Tina, Lund, A., Krarup, T., Holst, Jens Juul & Hornum, Mads, 6 Sep 2010, In: Journal of the Pancreas. 11, 5, p. 489-91 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-dependent insulinotropic polypeptide may enhance fatty acid re-esterification in subcutaneous abdominal adipose tissue in lean humans
Asmar, M., Simonsen, L., Madsbad, Sten, Stallknecht, Bente Merete, Holst, Jens Juul & Bülow, J., 1 Sep 2010, In: Diabetes. 59, 9, p. 2160-3 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes
Christensen, M., Knop, Filip Krag, Vilsbøll, Tina, Aaboe, K., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 9 Aug 2010, In: Regulatory Peptides. 163, 1-3, p. 96-101 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dipeptidyl peptidase expression during experimental colitis in mice
Yazbeck, R., Sulda, M. L., Howarth, G. S., Bleich, A., Raber, K., von Hörsten, S., Holst, Jens Juul & Abbott, C. A., 1 Aug 2010, In: Inflammatory Bowel Diseases. 16, 8, p. 1340-1351 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans
Meier, J. J., Ritter, P. R., Jacob, A., Menge, B. A., Deacon, Carolyn F., Schmidt, W. E., Nauck, M. A. & Holst, Jens Juul, 1 Aug 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 8, p. 4061-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men
Lapauw, B., Ouwens, M., 't Hart, L. M., Wuyts, B., Holst, Jens Juul, T'Sjoen, G., Kaufman, J. & Ruige, J. B., 1 Aug 2010, In: Diabetes Care. 33, 8, p. 1831-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects
Hansen, K. B., Vilsbøll, Tina, Bagger, J. I., Holst, Jens Juul & Knop, Filip Krag, 1 Jul 2010, In: The Journal of clinical endocrinology and metabolism. 95, 7, p. 3309-17 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action
Hare, K. J., Vilsbøll, Tina, Asmar, M., Deacon, Carolyn F., Knop, Filip Krag & Holst, Jens Juul, 1 Jul 2010, In: Diabetes. 59, 7, p. 1765-70 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans
Falkén, Y., Hellström, P. M., Sanger, G. J., Dewit, O., Dukes, G., Grybäck, P., Holst, Jens Juul & Näslund, E., 1 Jun 2010, In: Neurogastroenterology and Motility. 22, 6, p. e192-200Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of growth in infancy on body composition, insulin resistance, and concentration of appetite hormones in adolescence
Larnkjær, Anni, Schack-Nielsen, L., Mølgaard, Christian, Ingstrup, H. K., Holst, Jens Juul & Michaelsen, Kim F., 1 Jun 2010, In: American Journal of Clinical Nutrition. 91, 6, p. 1675-83 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans?
Asmar, M., Bache, M., Knop, Filip Krag, Madsbad, Sten & Holst, Jens Juul, 1 May 2010, In: The Journal of clinical endocrinology and metabolism. 95, 5, p. 2367-75 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The influence of nutrients, biliary-pancreatic secretions, and systemic trophic hormones on intestinal adaptation in a Roux-en-Y bypass model
Taqi, E., Wallace, L. E., de Heuvel, E., Chelikani, P. K., Zheng, H., Berthoud, H., Holst, Jens Juul & Sigalet, D. L., 1 May 2010, In: European Journal of Pediatric Surgery. Supplement. 45, 5, p. 987-95 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls
Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., Kurose, T., Deacon, Carolyn F., Holst, Jens Juul, Hirano, T., Inagaki, N. & Seino, Y., 22 Apr 2010, In: Journal of Diabetes Investigation. 1, 1-2, p. 56-9 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Automated detection of hypoglycemia-induced EEG changes recorded by subcutaneous electrodes in subjects with type 1 diabetes--the brain as a biosensor
Juhl, C. B., Højlund, K., Elsborg, R., Poulsen, M. K., Selmar, P. E., Holst, Jens Juul, Christiansen, C. & Beck-Nielsen, H., 1 Apr 2010, In: Diabetes Research and Clinical Practice. 88, 1, p. 22-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inappropriate glucagon response after oral compared with isoglycemic intravenous glucose administration in patients with type 1 diabetes
Hare, K. J., Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 1 Apr 2010, In: American Journal of Physiology: Endocrinology and Metabolism. 298, 4, p. E832-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat
Martins, C., Kulseng, B., King, N. A., Holst, Jens Juul & Blundell, J. E., 1 Apr 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 4, p. 1609-16 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus
Aaboe, K., Knop, Filip Krag, Vilsbøll, T., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, S. & Krarup, T. M., 1 Apr 2010, In: Diabetes, Obesity and Metabolism. 12, 4, p. 323-33 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery
McLaughlin, T., Peck, M., Holst, Jens Juul & Deacon, Carolyn F., Apr 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 4, p. 1851-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes
Kozawa, J., Okita, K., Imagawa, A., Iwahashi, H., Holst, Jens Juul, Yamagata, K. & Shimomura, I., 12 Mar 2010, In: Biochemical and Biophysical Research Communications. 393, 3, p. 410-3 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cardiovascular and metabolic effects of 48-h glucagon-like peptide-1 infusion in compensated chronic patients with heart failure
Halbirk, M., Nørrelund, H., Møller, N., Holst, Jens Juul, Schmitz, O., Nielsen, B. R. R., Nielsen-Kudsk, J. E., Nielsen, S. S., Nielsen, T. T., Eiskjaer, H., Bøtker, H. E. & Wiggers, H., 1 Mar 2010, In: American Journal of Physiology: Heart and Circulatory Physiology. 298, 3, p. H1096-H1102Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: new advances
Asmar, M. & Holst, Jens Juul, 1 Feb 2010, In: Current Opinion in Endocrinology, Diabetes and Obesity. 17, 1, p. 57-62 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of glucagon-like peptide-2 on arterial blood flow and cardiac parameters
Bremholm, L., Hornum, Mads, Andersen, U. B. & Holst, Jens Juul, 8 Jan 2010, In: Regulatory Peptides. 159, 1-3, p. 67-71 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of fat supplementation on postprandial GIP, GLP-1, ghrelin and IGFBP-1 levels: a pilot study on adolescents with type 1 diabetes
Lodefalk, M., Carlsson-Skwirut, C., Holst, Jens Juul, Aman, J. & Bang, P., 1 Jan 2010, In: Hormone research in pædiatrics. 73, 5, p. 355-362 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon and glucagon-like peptides 1 and 2
Holst, Jens Juul, 1 Jan 2010, In: Results and Problems in Cell Differentiation. 50, p. 121-35 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of glucagon-like Peptide-2 receptor agonists on colonic anastomotic wound healing
Redstone, H. A., Buie, W. D., Hart, D. A., Wallace, L., Hornby, P. J., Sague, S., Holst, Jens Juul & Sigalet, D. L., 1 Jan 2010, In: Gastroenterology Research and Practice. 2010, p. Article ID 672453 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes
Deacon, Carolyn F. & Holst, Jens Juul, Jan 2010, In: Expert Opinion on Investigational Drugs. 19, 1, p. 133-40 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls
Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., Kurose, T., Deacon, Carolyn F., Holst, Jens Juul, Hirano, T., Inagaki, N. & Seino, Y., Jan 2010, In: Journal of Diabetes Investigation. 1, 1/2, p. 56-59Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects
Brader, L. J., Holm, L., Mortensen, L., Thomsen, C., Astrup, A., Holst, Jens Juul, Vrese, M. D., Schrezenmeir, J. & Hermansen, K., 2010, In: Nutrition, Metabolism & Cardiovascular Diseases. 20, 2, p. 101-109 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of glucagon-like peptide-1 on alpha- and beta-cell function in C-peptide-negative type 1 diabetic patients
Kielgast, U., Asmar, M., Madsbad, Sten & Holst, Jens Juul, 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 5, p. 2492-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4207
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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