Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
- 2007
- Published
GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet
McClean, P. L., Irwin, N., Cassidy, R. S., Holst, Jens Juul, Gault, V. A. & Flatt, P. R., Dec 2007, In: American Journal of Physiology: Endocrinology and Metabolism. 293, 6, p. E1746-55Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
Schäfer, S. A., Tschritter, O., Machicao, F., Thamer, C., Stefan, N., Gallwitz, B., Holst, Jens Juul, Dekker, J. M., 't Hart, L. M., t'Hart, L. M., Nijpels, G., van Haeften, T. W., Häring, H. U. & Fritsche, A., Dec 2007, In: Diabetologia. 50, 12, p. 2443-50 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal
Goldfine, A. B., Mun, E. C., Devine, E., Bernier, R., Baz-Hecht, M., Jones, D. B., Schneider, B. E., Holst, Jens Juul & Patti, M. E., Dec 2007, In: The Journal of clinical endocrinology and metabolism. 92, 12, p. 4678-85 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion
El-Ouaghlidi, A., Rehring, E., Holst, Jens Juul, Schweizer, A., Foley, J., Holmes, D. & Nauck, M. A., Nov 2007, In: The Journal of clinical endocrinology and metabolism. 92, 11, p. 4165-71 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion
Hagemann, D., Holst, Jens Juul, Gethmann, A., Banasch, M., Schmidt, W. E. & Meier, J. J., 4 Oct 2007, In: Regulatory Peptides. 143, 1-3, p. 64-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas
de Heer, J., Pedersen, J., Ørskov, Cathrine & Holst, Jens Juul, Oct 2007, In: Diabetologia. 50, 10, p. 2135-42 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion
Cani, P. D., Holst, Jens Juul, Drucker, D. J., Delzenne, N. M., Thorens, B., Burcelin, R. & Knauf, C., 30 Sep 2007, In: Molecular and Cellular Endocrinology. 276, 1-2, p. 18-23 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans
Meier, J. J., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., Sep 2007, In: American Journal of Physiology: Endocrinology and Metabolism. 293, 3, p. E849-56Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes
Pörksen, S., Nielsen, L. B., Kaas, A., Kocova, M., Chiarelli, F., Ørskov, Cathrine, Holst, Jens Juul, Ploug, K. B., Hougaard, P., Hansen, L. & Mortensen, H. B., Aug 2007, In: The Journal of clinical endocrinology and metabolism. 92, 8, p. 2910-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate
Holst, Jens Juul, Hartmann, Bolette, Gottschalck, I. B., Jeppesen, Palle Bekker, Miholic, J. & Henriksen, D. B., Jul 2007, In: Scandinavian Journal of Gastroenterology. 42, 7, p. 814-20 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2
Sigalet, D. L., Wallace, L. E., Holst, Jens Juul, Martin, G. R., Kaji, T., Tanaka, H. & Sharkey, K. A., Jul 2007, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 293, 1, p. G211-21Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes
Nielsen, L. B., Ploug, K. B., Swift, P., Ørskov, Cathrine, Jansen-Olesen, I., Chiarelli, F., Holst, Jens Juul, Hougaard, P., Pörksen, S., Holl, R., de Beaufort, C., Gammeltoft, S., Rorsman, P., Mortensen, H. B. & Hansen, L., Jun 2007, In: European Journal of Endocrinology. Supplement. 156, 6, p. 663-71 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus
Knop, F. K., Vilsbøll, Tina, Madsbad, Sten, Holst, Jens Juul, Krarup, T., Knop, Filip Krag, Vilsbøll, Tina, Madsbad, Sten, Holst, J. M. & Krarup, T., 1 Apr 2007, In: Diabetologia. 50, 4, p. 797-805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus
Knop, Filip Krag, Vilsbøll, T., Madsbad, Sten, Holst, Jens Juul & Krarup, T., Apr 2007, In: Diabetologia. 50, 4, p. 797-805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disassociation of bone resorption and formation by GLP-2: a 14-day study in healthy postmenopausal women
Henriksen, D. B., Alexandersen, P., Hartmann, Bolette, Adrian, C. L., Byrjalsen, I., Bone, H. G., Holst, Jens Juul & Christiansen, C., Mar 2007, In: Bone. 40, 3, p. 723-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gastric emptying of glucose solution and associated plasma concentrations of GLP-1, GIP, and PYY before and after fundoplication
Miholic, J., Hoffmann, M., Holst, Jens Juul, Lenglinger, J., Mittlböck, M., Bergmann, H. & Stacher, G., Feb 2007, In: Surgical Endoscopy. 21, 2, p. 309-14 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preserved GLP-1 effects in a diabetic patient with Cushing's disease
Ritzel, R. A., Kleine, N., Holst, Jens Juul, Willms, B., Schmiegel, W. & Nauck, M. A., Feb 2007, In: Experimental and Clinical Endocrinology and Diabetes. 115, 2, p. 146-50 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Small-molecule agonists for the glucagon-like peptide 1 receptor
Knudsen, L. B., Kiel, D., Teng, M., Behrens, C., Bhumralkar, D., Kodra, J. T., Holst, J. J., Jeppesen, C. B., Johnson, M. D., de Jong, J. C., Jorgensen, A. S., Kercher, T., Kostrowicki, J., Madsen, P., Olesen, P. H., Petersen, J. S., Poulsen, F., Sidelmann, U. G., Sturis, J., Truesdale, L. & 2 others, , 16 Jan 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 3, p. 937-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The antagonistic metabolite of GLP-1, GLP-1 (9-36)amide, does not influence gastric emptying and hunger sensations in man
Nagell, C. F., Pedersen, J. F. & Holst, Jens Juul, Jan 2007, In: Scandinavian Journal of Gastroenterology. 42, 1, p. 28-33 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acute effects of ghrelin administration on glucose and lipid metabolism.
Vestergaard, E. T., Djurhuus, C. B., Gjedsted, J., Nielsen, S., Møller, N., Holst, Jens Juul, Jørgensen, J. O. L. & Schmitz, O., 2007, In: Journal of Clinical Endocrinology and Metabolism. 93, 2, p. 438-444 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate
Holst, Jens Juul, Hartmann, B., Gottschalck, I. B., Jeppesen, P. B., Miholic, J. & Henriksen, D. B., 2007, In: Scandinavian Journal of Gastroenterology. 42, 7, p. 814-820 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cecal infusion of butyrate increases intestinal cell proliferation in piglets
Kien, C. L., Blauwiekel, R., Bunn, J. Y., Jetton, T. L., Frankel, W. L. & Holst, Jens Juul, 2007, In: Journal of Nutrition. 137, 4, p. 916-922 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes
Nielsen, L. B., Ploug, K. B., Swift, P., Ørskov, A. C., Jansen-Olesen, I., Chiarelli, F., Holst, J. J., Hougaard, P. P., Porksen, S., Holl, R., Beaufort, C. D., Gammeltoft, S., Rorsman, P., Mortensen, H. B., Hansen, L., Nielsen, L. B., Ploug, K. B., Swift, P., Ørskov, C., Jansen-Olesen, I. & 11 others, , 2007, In: European Journal of Endocrinology. 156, 6, p. 663-71 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disassociation of bone resorption and formation by GLP-2 - A 14-day study in healthy postmenopausal women
Henriksen, D. B., Alexandersen, P., Hartmann, B., Adrian, C. L., Byrjalsen, I., Bone, H. G., Holst, Jens Juul & Christiansen, C., 2007, In: Bone. 40, 3, p. 723-729 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of dairy calcium or supplementary calcium on postprandial fat metabolism, appetite, and subsequent energy intake
Lorenzen, J. K., Nielsen, S., Holst, Jens Juul, Tetens, Inge , Rehfeld, Jens Frederik & Astrup, A., 2007, In: American Journal of Clinical Nutrition. 85, 3, p. 678-687 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acids concentration in obese males
Sloth, B., Davidsen, L., Holst, Jens Juul, Flint, A. & Astrup, A., 2007, In: American Journal of Physiology: Endocrinology and Metabolism. 293, 2, p. E604-E609Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2
Sigalet, D. L., Wallace, L. E., Holst, Jens Juul, Martin, G. R., Kaji, T., Tanaka, H. & Sharkey, K. A., 2007, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 293, 1, p. G211-G221Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding.
Korner, J., Bessler, M., Inabnet, W., Taveras, C. & Holst, Jens Juul, 2007, In: Surgery for Obesity and Related Diseases. 3, 6, p. 597-601 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats.
Simonsen, L., Pilgaard, S., Orskov, C., Rosenkilde, Mette, Hartmann, B., Holst, Jens Juul & Deacon, Carolyn F., 2007, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 293, 1, p. G288-95Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet
McClean, P. L., Irwin, N., Cassidy, R. S., Holst, Jens Juul, Gault, V. A. & Flatt, P. R., 2007, In: American Journal of Physiology: Endocrinology and Metabolism. 293, 6, p. E1746-E1755Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion
Cani, P. D., Holst, Jens Juul, Drucker, D. J., Delzenne, N. M., Thorens, B., Burcelin, R. & Knauf, C., 2007, In: Molecular and Cellular Endocrinology. 276, 1-2, p. 18-23 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gastric emptying of glucose solution and associated plasma concentrations of GLP-1, GIP, and PYY before and after fundoplication
Miholic, J., Hoffmann, M., Holst, Jens Juul, Lenglinger, J., Mittlbock, M., Bergmann, H. & Stacher, G., 2007, In: Surgical Endoscopy and Other Interventional Techniques. 21, 2, p. 309-314 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gastrointestinal function and metabolic control after construction of an orthotopic ileal neobladder in bladder cancer.
Thorstenson, A., Jacobsson, H., Onelöv, E., Holst, Jens Juul, Hellström, P. M. & Kinn, A., 2007, In: Scandinavian Journal of Urology and Nephrology. 41, 1, p. 14-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion
Hagemann, D., Holst, Jens Juul, Gethmann, A., Banasch, M., Schmidt, W. E. & Meier, J. J., 2007, In: Regulatory Peptides. 143, 1-3, p. 64-68 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide 2 has limited efficacy to increase nutrient absorption in fetal and preterm pigs
Sangild, Per Torp, Malo, C., Schmidt, M., Petersen, Y. M., Elnif, J., Holst, Jens Juul & Bunddington, R. K., 2007, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 293, 6, p. R2179-R2184 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-2 in umbilical cord blood from mature infants
Bodé, S., Hartmann, Bolette, Holst, Jens Juul & Greisen, Gorm, 2007, In: Neonatology. 91, 1, p. 49-53 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-2 in umbilical cord blood from mature infants
Bode, S., Hartmann, B., Holst, Jens Juul & Greisen, Gorm, 2007, In: Neonatology. 91, 1, p. 49-53 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatic autoregulation: response of glucose production and gluconeogenesis to increased glycogenolysis
Stæhr, P. A., Hother-Nielsen, O., Beck-Nielsen, H., Roden, M., Stingl, H., Holst, Jens Juul, Jones, P. K., Chandramouli, V. & Landau, B. R., 2007, In: American Journal of Physiology: Endocrinology and Metabolism. 292, 5, p. E1265-E1269Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
Schafer, S. A., Tschritter, O., Machicao, F., Thamer, C., Stefan, N., Gallwitz, B., Holst, Jens Juul, Dekker, J. M., t'Hart, L. M., Nijpels, G., Haeften, T. W. V., Haring, H. U. & Fritsche, A., 2007, In: Diabetologia. 50, 12, p. 2443-2450 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes
Porksen, S., Nielsen, L. B., Kaas, A., Kocova, M., Chiarelli, F., Orskov, C., Holst, Jens Juul, Ploug, K. B., Hougaard, P. P., Hansen, L. & Mortensen, H. B., 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 8, p. 2910-2916 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes
Azuma, K., Rádiková, Z., Mancino, J., Toledo, F. G. S., Thomas, E., Kangani, C., Dalla Man, C., Cobelli, C., Holst, Jens Juul, Deacon, Carolyn F., He, Y., Ligueros-Saylan, M., Serra, D., Foley, J. E. & Kelley, D. E., 2007, In: Journal of Clinical Endocrinology and Metabolism. 93, 2, p. 459-464 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinks
Nilsson, M., Holst, Jens Juul & Bjorck, I. M. E., 2007, In: American Journal of Clinical Nutrition. 85, 4, p. 996-1004 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New horizons in diabetes therapy
Holst, Jens Juul & Deacon, Carolyn F., 2007, In: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 7, 1, p. 49-55 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Normal secretion of the incretin hormones glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 during gestational diabetes mellitus
Cypryk, K., Vilsbøll, Tina, Nadel, I., Smyczynska, J., Holst, Jens Juul & Lewinski, A., 2007, In: Gynecological Endocrinology. 23, 1, p. 58-62 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal
Goldfine, A. B., Mun, E. C., Devine, E., Bernier, R., Baz-Hecht, M., Jones, D. B., Schneider, B. E., Holst, Jens Juul & Patti, M. E., 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 12, p. 4678-4685 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT.
He, Y., Wang, Y., Bullock, J. M., Deacon, Carolyn F., Holst, Jens Juul, Dunning, B. E., Ligueros-Saylan, M. & Foley, J. E., 2007, In: Journal of Clinical Pharmacology. 47, 5, p. 633-41 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus.
He, Y., Serra, D., Wang, Y., Campestrini, J., Riviere, G., Deacon, Carolyn F., Holst, Jens Juul, Schwartz, S., Nielsen, J. C. & Ligueros-Saylan, M., 2007, In: Clinical Pharmacokinetics. 46, 7, p. 577-88 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Porcine glucagon-like peptide-2: structure, signaling, metabolism and effects
Pedersen, N. B., Hjøllund, K. R., Johnsen, A. H., Ørskov, Cathrine, Rosenkilde, Mette, Hartmann, B. & Holst, Jens Juul, 2007, In: Regulatory Peptides. 146, 1-3, p. 310-320 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preserved GLP-1 effects in a diabetic patient with Cushing's disease
Ritzel, R. A., Kleine, N., Holst, Jens Juul, Willms, B., Schmiegel, W. & Nauck, M. A., 2007, In: Experimental and Clinical Endocrinology and Diabetes. 115, 2, p. 146-150 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?
Knop, F. K., Vilsbøll, Tina, Højberg, P. V., Larsen, S., Madsbad, Sten, Vølund, A., Holst, Jens Juul & Krarup, T., 2007, In: Diabetes. 56, 8, p. 1951-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4207
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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