Thomas Jespersen

Thomas Jespersen

Professor

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    ORCID: 0000-0001-6575-360X

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    1. Published

      hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kinetics.

      Grunnet, Morten, Olesen, Søren-Peter, Klærke, Dan Arne & Jespersen, Thomas, 2005, In: Biochemical and Biophysical Research Communications. 328, 4, p. 1146-53 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      [68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction

      Bentsen, Simon, Clemmensen, Andreas Høeg, Loft, Mathias Hougaard, Flethøj, M., Debes, Karina Poulsdóttir, Ludvigsen, Trine Pagh, Larsen, C. B., Kirchhoff, J., Olsen, Lisbeth Høier, Møller, J. E., Andersen, Thomas Lund, Johannesen, Helle Hjorth, Jespersen, Thomas & Kjær, Andreas, 2021, In: Diagnostics. 11, 10, 1807.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Ventricular tachycardia in a Brugada syndrome patient caused by a novel deletion in SCN5A

      Tfelt-Hansen, J., Jespersen, Thomas, Hofman-Bang, J., Rasmussen, Hanne Borger, Cedergreen, P., Skovby, F., Abriel, H., Svendsen, Jesper Hastrup, Olesen, S., Christiansen, M. & Haunso, S., 2009, In: Canadian Journal of Cardiology. 25, 3, p. 156-60 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Ventricular Arrhythmias in First Acute Myocardial Infarction: Epidemiology, Mechanisms, and Interventions in Large Animal Models

      Sattler, S. M., Skibsbye, L., Dr Linz, Dominik Karl, Lubberding, Anniek Frederike, Tfelt-Hansen, Jacob & Jespersen, Thomas, 2019, In: Frontiers in Cardiovascular Medicine. 6, 14 p., 158.

      Research output: Contribution to journal › Review › Research › peer-review

    5. Published

      Utility of left atrial strain for predicting atrial fibrillation following ischemic stroke

      Rasmussen, S. M. A., Olsen, F. J., Jorgensen, P. G., Fritz-Hansen, T., Jespersen, Thomas, Gislason, Gunnar Hilmar & Biering-Sørensen, Tor, 2019, In: International Journal of Cardiovascular Imaging. 35, 9, p. 1605-1613

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Usefulness of left atrial strain for predicting incident atrial fibrillation and ischaemic stroke in the general population

      Alhakak, Alia Saed, Biering-Sørensen, S. R., Møgelvang, R., Modin, D., Jensen, G. B., Schnohr, P., Iversen, A. Z., Svendsen, Jesper Hastrup, Jespersen, Thomas, Gislason, Gunnar Hilmar & Biering-Sørensen, Tor, 2022, In: European heart journal. Cardiovascular Imaging. 23, 3, p. 363-371 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Urinary markers of nucleic acid oxidation increase with age, obesity and insulin resistance in Danish children and adolescents

      Jors, A., Lund, M. A. ,. V., Jespersen, Thomas, Hansen, Torben, Poulsen, Henrik Enghusen & Holm, Jens-Christian, 2020, In: Free Radical Biology and Medicine. 155, p. 81-86

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis

      Tommiska, J., Känsäkoski, J., Skibsbye, L., Vaaralahti, K., Liu, X., Lodge, E. J., Tang, C., Yuan, L., Fagerholm, R., Kanters, J. K., Lahermo, P., Kaunisto, M., Keski-Filppula, R., Vuoristo, S., Pulli, K., Ebeling, T., Valanne, L., Sankila, E-M., Kivirikko, S., Lääperi, M. & 15 others, Casoni, F., Giacobini, P., Phan-Hug, F., Buki, T., Tena-Sempere, M., Pitteloud, N., Veijola, R., Lipsanen-Nyman, M., Kaunisto, K., Mollard, P., Andoniadou, C. L., Hirsch, J. A., Varjosalo, M., Jespersen, Thomas & Raivio, T., 3 Nov 2017, In: Nature Communications. 8, 1, 11 p., 1289.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Transmural expression of ion channels and transporters in human nondiseased and end-stage failing hearts

      Soltysinska, E., Olesen, Søren-Peter, Christ, T., Wettwer, E., Varró, A., Grunnet, Morten & Jespersen, Thomas, 2009, In: Pflügers Archiv: European Journal of Physiology. 459, 1, p. 11-23 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Transgene stability for three replication-competent murine leukemia virus vectors

      Duch, M. R., Carrasco, M. L., Jespersen, T., Hansen, B. D., Pedersen, F. S. & Jespersen, Thomas, 31 Mar 2004, In: Gene. 329, p. 61-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Time-dependent antiarrhythmic effects of flecainide on induced atrial fibrillation in horses

      Carstensen, Helena, Hesselkilde, E. Z., Fenner, Merle Friederike, Loft-Andersen, A. V., Flethøj, M., Kanters, Jørgen K., Sattler, Stefan M, Tfelt-Hansen, Jacob, Pehrson, S., Jespersen, Thomas & Buhl, Rikke, 2018, In: Journal of Veterinary Internal Medicine. 32, 5, p. 1708-1717 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Time matters: characterization of fibroblast-like cells harvested from pig profundus tendon stored at room temperature at different postmortem time intervals

      Ozhathil, Lijo Cherian, Chen, Y., Nissen, Sarah Dalgas, Banner, Jytte, Tfelt-Hansen, Jacob & Jespersen, Thomas, 2022, In: In Vitro Cellular and Developmental Biology - Animal. 58, p. 633–637

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/- mice

      von Schoubye, N. L., Frederiksen, K., Kristiansen, Uffe, Petersen, A. V., Dalby, N. O., Grunnet, M., Jensen, H. S., Jespersen, Thomas, Sohal, V. S. & Perrier, Jean-Francois Marie, 2018, In: Neuroscience Letters. 662, p. 29-35 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome

      Winkel, B. G., Yuan, L., Olesen, Morten Steen Salling, Sadjadieh, G., Wang, Y., Risgaard, B., Jabbari, R., Haunsø, Stig, Holst, A. G., Hollegaard, M. V., Tfelt-Hansen, J. & Jespersen, Thomas, Jun 2015, In: Heart rhythm : the official journal of the Heart Rhythm Society. 12, 6, p. 1241-1249 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      The role of CAV3 in long-QT syndrome: clinical and functional assessment of a caveolin-3/Kv11.1 double heterozygote versus caveolin-3 single heterozygote

      Hedley, P. L., Kanters, Jørgen K., Dembic, M., Jespersen, Thomas, Skibsbye, L., Aidt, F. H., Eschen, O., Graff, C., Behr, E. R., Schlamowitz, S., Corfield, V., McKenna, W. J. & Christiansen, M., Oct 2013, In: Circulation: Cardiovascular Genetics. 6, 5, p. 452-61 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      The impact of an atrial septal defect on the progression of atrial tachypacing-induced atrial fibrillation in a Danish Landrace pig: A case report

      Saljic, Arnela, Hertel, Julie Norup, Leonhardt, C., Nissen, Sarah Dalgas, Dobrev, D., Jepps, Thomas Andrew Qvistgaard, Jespersen, Thomas & Sattler, Stefan M, 2022, In: IJC Heart and Vasculature. 40, 3 p., 101054.

      Research output: Contribution to journal › Letter › Research › peer-review

    17. Published

      The gut microbial-derived metabolite trimethylamine N-oxide: A missing link between lifestyle-components and atrial fibrillation?

      Gawalko, M., Jespersen, Thomas, Dobrev, D. & Dr Linz, Dominik Karl, 2020, In: IJC Heart and Vasculature. 29, 3 p., 100581.

      Research output: Contribution to journal › Editorial › Research › peer-review

    18. Published

      The corticosteroid hormone induced factor: a new modulator of KCNQ1 channels?

      Jespersen, Thomas, Grunnet, Morten, Rasmussen, Hanne Borger, Jørgensen, N. B., Jensen, H., Angelo, K., Olesen, Søren-Peter & Klærke, Dan Arne, 2006, In: Biochemical and Biophysical Research Communications. 341, 4, p. 979-88 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      The arrhythmogenic calmodulin mutation D129G dysregulates cell growth, calmodulin-dependent kinase II activity, and cardiac function in zebrafish

      Berchtold, Martin Werner, Zacharias, T., Kulej, K., Wang, K., Torggler, R., Jespersen, Thomas, Chen, J. N., Larsen, M. R. & la Cour, J. M., 2016, In: Journal of Biological Chemistry. 291, 52, p. 26636-26646 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      The KCNQ5 potassium channel from mouse: a broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes.

      Jensen, H. S., Callø, Kirstine, Jespersen, Thomas, Jensen, B. S. & Olesen, Søren-Peter, 2005, In: Brain Research. 139, 1, p. 52-62 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      The KCNQ1 potassium channel: from gene to physiological function.

      Jespersen, Thomas, Grunnet, Morten & Olesen, Søren-Peter, 2005, In: Physiology. 20, p. 408-16 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family.

      Jespersen, Thomas, Membrez, M., Nicolas, C. S., Pitard, B., Staub, O., Olesen, Søren-Peter, Baró, I. & Abriel, H., 2007, In: Cardiovascular Research. 74, 1, p. 64-74 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts

      Kirchhoff, J. E., Skarsfeldt, M., Muthukumarasamy, K. M., Simó-Vicens, R., Bomholtz, Sofia Hammami, Abildgaard, L., Jespersen, Thomas, Sørensen, U. S., Grunnet, Morten, Bentzen, Bo Hjorth & Diness, Jonas Goldin, 2019, In: Frontiers in Pharmacology. 10, 13 p., 668.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats

      Sobota, V., Gatta, G., van Hunnik, A., van Tuijn, I., Kuiper, M., Milnes, J., Jespersen, Thomas, Schotten, U. & Verheule, S., 2021, In: Frontiers in Pharmacology. 11, 13 p., 608410.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs

      Diness, Jonas Goldin, Skibsbye, L., Simó-Vicens, R., Louro Larupa dos Santos, J., Lundegaard, Pia Rengtved, Citerni, C., Sauter, D. R. P., Bomholtz, Sofia Hammami, Svendsen, Jesper Hastrup, Olesen, Søren-Peter, Sørensen, U. S., Jespersen, Thomas, Grunnet, Morten & Bentzen, Bo Hjorth, 10 Oct 2017, In: Circulation: Arrhythmia and Electrophysiology. 10, 19 p., e005125.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Synergistic antiarrhythmic effect of combining inhibition of Ca(2+)-activated K(+) (SK) channels and voltage-gated Na(+) channels in an isolated heart model of atrial fibrillation

      Kirchhoff, J. E., Goldin Diness, J., Sheykhzade, Majid, Grunnet, M. & Jespersen, Thomas, Feb 2015, In: Heart rhythm : the official journal of the Heart Rhythm Society. 12, 2, p. 409-18 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Subtype-specific, bi-component inhibition of SK channels by low internal pH.

      Peitersen, T., Jespersen, Thomas, Jorgensen, N. K., Olesen, Søren-Peter & Grunnet, Morten, 2006, In: Biochemical and Biophysical Research Communications. 343, 3, p. 943-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Structural and electro-anatomical characterization of the equine pulmonary veins: implications for atrial fibrillation

      Kjeldsen, S. T., Nissen, Sarah Dalgas, Saljic, Arnela, Hesselkilde, E. M., Carstensen, Helena, Sattler, Stefan M, Jespersen, Thomas, Dr Linz, Dominik Karl, Hopster-Iversen, Charlotte, Kutieleh, R., Sanders, P. & Buhl, Rikke, 2024, In: Journal of Veterinary Cardiology. 52, p. 1-13

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Stability of Circulating Blood-Based MicroRNAs - Pre-Analytic Methodological Considerations

      Glinge, C., Clauss, S., Boddum, K., Jabbari, R., Jabbari, J., Risgaard, B., Tomsits, P., Hildebrand, B., Kääb, S., Wakili, R., Jespersen, Thomas & Tfelt-Hansen, Jacob, 2017, In: PLOS ONE. 12, 2, 16 p., e0167969.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Solid-phase synthesis and biological activity of a thioether analogue of conotoxin G1.

      Bondebjerg, J., Grunnet, Morten, Jespersen, Thomas & Meldal, Morten Peter, 2003, In: ChemBioChem. 4, 2-3, p. 186-94 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria

      Skibsbye, L., Poulet, C., Diness, Jonas Goldin, Bentzen, Bo Hjorth, Yuan, L., Kappert, U., Matschke, K., Wettwer, E., Ravens, U., Grunnet, M., Christ, T. & Jespersen, Thomas, 1 Jul 2014, In: Cardiovascular Research. 103, 1, p. 156-67 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarisation in human atria.

      Skibsbye, L., Poulet, C., Diness, Jonas Goldin, Bentzen, Bo Hjorth, Yuan, L., Kappert, U., Matschke, K., Wettwer, E., Ravens, U., Grunnet, M., Christ, T. & Jespersen, Thomas, Jul 2014, In: Cardiovascular Research. 103, 1, p. 156-167 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Sleep apnea and atrial fibrillation: challenges in clinical and translational research

      Linz, Benedikt Maximilian, Hertel, Julie Norup, Hendriks, J., Saljic, Arnela, Dobrev, D., Baumert, M., Jespersen, Thomas & Dr Linz, Dominik Karl, 2022, In: Expert Review of Cardiovascular Therapy. 20, 2, p. 101-109

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Sick sinus syndrome, progressive cardiac conduction disease, atrial flutter and ventricular tachycardia caused by a novel SCN5A mutation

      Holst, A. G., Liang, B., Jespersen, Thomas, Bundgård, Henning, Haunso, S., Svendsen, Jesper Hastrup & Tfelt-Hansen, J., 2010, In: Cardiology. 115, 4, p. 311-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Screening of KCNN3 in patients with early-onset lone atrial fibrillation

      Olesen, M. S., Jabbari, J., Holst, A. G., Nielsen, J. B., Steinbrüchel, D. A., Jespersen, T., Haunsø, Stig, Svendsen, Jesper Hastrup & Jespersen, Thomas, 2011, In: Europace. 13, 7, p. 963-967 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Researchers in cardiology – Why and how to get on Twitter?

      Benjamin Fyenbo, D., Charlotte Frederiksen, T., Dr Linz, Dominik Karl, Jespersen, Thomas, Dobrev, D., Gislason, Gunnar Hilmar, Betz, K., Saljic, Arnela & Nielsen Holck, E., 2022, In: IJC Heart and Vasculature. 40, 101010.

      Research output: Contribution to journal › Review › Research › peer-review

    37. Published

      Repeated exposure to transient obstructive sleep apnea–related conditions causes an atrial fibrillation substrate in a chronic rat model

      Linz, Benedikt Maximilian, Hohl, M., Lang, L., Wong, D. W. L., Nickel, A. G., De La Torre, C., Sticht, C., Wirth, K., Boor, P., Maack, C., Speer, T., Jespersen, Thomas, Schotten, U., Sanders, P., Böhm, M. & Dr Linz, Dominik Karl, 2021, In: Heart Rhythm. 18, 3, p. 455-464

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Regulation of Kv1.4 potassium channels by PKC and AMPK kinases

      Andersen, M. N., Skibsbye, L., Saljic, Arnela, Larsen, M. Z., Rasmussen, Hanne Borger & Jespersen, Thomas, 20 Dec 2018, In: Channels (Austin). 12, 1, p. 34-44

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Regulation of APD and Force by the Na+/Ca2+ Exchanger in Human-Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue

      Ismaili, D., Gurr, K., Horvath, A., Yuan, L., Lemoine, M. D., Schulz, C., Sani, J., Petersen, J., Reichenspurner, H., Kirchhof, P., Jespersen, Thomas, Eschenhagen, T., Hansen, A., Koivumaeki, J. T. & Christ, T., 2022, In: Cells. 11, 15, 15 p., 2424.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Regulation and physiological function of Na(v) 1.5 and KCNQ1 channels

      Jespersen, Thomas, 2011, In: Acta Physiologica (Print). 202 Suppl 683, p. 1-26 26 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Refractoriness in human atria: Time and voltage dependence of sodium channel availability

      Skibsbye, L., Jespersen, Thomas, Christ, T., Maleckar, M. M., van den Brink, J., Tavi, P. & Koivumäki, J. T., Dec 2016, In: Journal of Molecular and Cellular Cardiology. 101, p. 26-34 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Recruitment of motor neuronal persistent inward currents shapes withdrawal reflexes in the frog

      Grunnet, Morten, Jespersen, Thomas & Perrier, Jean-Francois Marie, 2004, In: Journal of Neuroscience Research. 78, p. 845-854

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction

      Hundahl, L. A., Tfelt-Hansen, Jacob & Jespersen, Thomas, Nov 2017, In: Journal of Cardiovascular Pharmacology and Therapeutics. 22, 6, p. 514-528 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Pulmonary vein firing initiating atrial fibrillation in the horse: Oversized dimensions but similar mechanisms

      Dr Linz, Dominik Karl, Hesselkilde, E., Kutieleh, R., Jespersen, Thomas, Buhl, Rikke & Sanders, P., 2020, In: Journal of Cardiovascular Electrophysiology. 31, 5, p. 1211-1212

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Population-based pediatric reference values for serum parathyroid hormone, vitamin D, calcium, and phosphate in Danish/North-European white children and adolescents

      Vissing Landgrebe, A., Lund, Morten Asp Vonsild, Lausten-Thomsen, U., Frithioff-Bøjsøe, C., Fonvig, Cilius Esmann, Lind Plesner, J., Aas Holm, L., Jespersen, Thomas, Hansen, Torben & Holm, Jens-Christian, 2021, In: Clinica Chimica Acta. 523, p. 483-490

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Pharmacologically induced long QT type 2 can be rescued by activation of IKs with benzodiazepine R-L3 in isolated guinea pig cardiomyocytes

      Nissen, J. D., Diness, Jonas Goldin, Diness, T. G., Hansen, R. S., Grunnet, Morten & Jespersen, Thomas, 2009, In: Journal of Cardiovascular Pharmacology. 54, 2, p. 169-77 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Pharmacological rescue of mutated K(v)3.1 ion-channel linked to progressive myoclonus epilepsies

      Munch, A. S., Saljic, Arnela, Boddum, K., Grunnet, Morten, Hougaard, C. & Jespersen, Thomas, 2018, In: European Journal of Pharmacology. 833, p. 255-262

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Pharmacological modulation of SK3 channels

      Grunnet, Morten, Jespersen, Thomas, Angelo, K., Frøkjær-Jensen, Christian, Klærke, Dan Arne, Olesen, Poul & Jensen, B. S., 1 Jun 2001, In: Neuropharmacology. 40, 7, p. 879-887 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut reduces atrial fibrillation susceptibility in obese spontaneously hypertensive rats

      Linz, Benedikt Maximilian, Hohl, M., Mishima, R., Saljic, Arnela, Lau, D. H., Jespersen, Thomas, Schotten, U., Sanders, P. & Dr Linz, Dominik Karl, 2020, In: IJC Heart and Vasculature. 28, 7 p., 100534.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Pharmacological inhibition of acetylcholine-regulated potassium current (IK,ACh) prevents atrial arrhythmogenic changes in a rat model of repetitive obstructive respiratory events

      Linz, Benedikt Maximilian, Thostrup, A. H., Saljic, Arnela, Rombouts, K., Hertel, Julie Norup, Hohl, M., Milnes, J., Tfelt-Hansen, Jacob, Dr Linz, Dominik Karl & Jespersen, Thomas, Feb 2022, In: Heart Rhythm O2. 3, 1, p. 97-104

      Research output: Contribution to journal › Journal article › Research › peer-review

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