Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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The physiology of glucagon-like peptide 1.
Holst, Jens Juul, 2007, In: Physiological Reviews. 87, 4, p. 1409-39 30 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The intestinotrophic peptide, glp-2, counteracts intestinal atrophy in mice induced by the epidermal growth factor receptor inhibitor, gefitinib.
Hare, K. J., Hartmann, B., Kissow, Hannelouise, Holst, Jens Juul & Poulsen, Steen Seier, 2007, In: Clinical Cancer Research. 13, 17, p. 5170-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance.
Knop, F. K., Vilsbøll, Tina, Højberg, P. V., Larsen, S., Madsbad, Sten, Holst, Jens Juul & Krarup, T., 2007, In: Regulatory Peptides. 144, 1-3, p. 123-30 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose
Utzschneider, K. M., Tong, J., Montgomery, B., Udayasankar, J., Gerchman, F., Marcovina, S. M., Watson, C. E., Ligueros-Saylan, M. A., Foley, J. E., Holst, Jens Juul, Deacon, Carolyn F. & Kahn, S. E., 2007, In: Diabetes Care. 31, 1, p. 108-113 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients.
Balas, B., Baig, M. R., Watson, C., Dunning, B. E., Ligueros-Saylan, M., Wang, Y., He, Y., Darland, C., Holst, Jens Juul, Deacon, Carolyn F., Cusi, K., Mari, A., Foley, J. E. & DeFronzo, R. A., 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 4, p. 1249-55 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion
Ouaghlidi, A. E., Rehring, E., Holst, Jens Juul, Schweizer, A., Foley, J., Holmes, D. & Nauck, M. A., 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 11, p. 4165-4171 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion
El-Ouaghlidi, A., Rehring, E., Holst, Jens Juul, Schweizer, A., Foley, J., Holmes, D. & Nauck, M. A., Nov 2007, In: The Journal of clinical endocrinology and metabolism. 92, 11, p. 4165-71 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The antagonistic metabolite of GLP-1, GLP-1 (9-36)amide, does not influence gastric emptying and hunger sensations in man
Nagell, C. F., Pedersen, J. F. & Holst, Jens Juul, Jan 2007, In: Scandinavian Journal of Gastroenterology. 42, 1, p. 28-33 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas
de Heer, J., Pedersen, J., Ørskov, Cathrine & Holst, Jens Juul, Oct 2007, In: Diabetologia. 50, 10, p. 2135-42 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects
Meier, J. J., Deacon, Carolyn F., Schmidt, W. E., Holst, Jens Juul & Nauck, M. A., 2007, In: Diabetologia. 50, 4, p. 806-813 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1.
de Heer, J. & Holst, Jens Juul, 2007, In: Diabetes. 56, 2, p. 438-43 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Small-molecule agonists for the glucagon-like peptide 1 receptor
Knudsen, L. B., Kiel, D., Teng, M., Behrens, C., Bhumralkar, D., Kodra, J. T., Holst, J. J., Jeppesen, C. B., Johnson, M. D., de Jong, J. C., Jorgensen, A. S., Kercher, T., Kostrowicki, J., Madsen, P., Olesen, P. H., Petersen, J. S., Poulsen, F., Sidelmann, U. G., Sturis, J., Truesdale, L. & 2 others, , 16 Jan 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 3, p. 937-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor
Teng, M., Johnson, M. D., Thomas, C., Kiel, D., Lakis, J. N., Kercher, T., Aytes, S., Kostrowicki, J., Bhumralkar, D., Truesdale, L., May, J., Sidelman, U., Kodra, J. T., Jørgensen, A. S., Olesen, P. H., Jong, J. C. D., Madsen, P., Behrens, C., Pettersson, I., Knudsen, L. B. & 2 others, , 2007, In: Bioorganic & Medicinal Chemistry Letters. 17, 19, p. 5472-5478 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans
Meier, J. J., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., Sep 2007, In: American Journal of Physiology: Endocrinology and Metabolism. 293, 3, p. E849-56Research output: Contribution to journal › Journal article › Research › peer-review
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Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans
Meier, J. J., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., 2007, In: American Journal of Physiology: Endocrinology and Metabolism. 293, 3, p. E849-E856Research output: Contribution to journal › Journal article › Research › peer-review
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Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?
Knop, F. K., Vilsbøll, Tina, Højberg, P. V., Larsen, S., Madsbad, Sten, Vølund, A., Holst, Jens Juul & Krarup, T., 2007, In: Diabetes. 56, 8, p. 1951-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Preserved GLP-1 effects in a diabetic patient with Cushing's disease
Ritzel, R. A., Kleine, N., Holst, Jens Juul, Willms, B., Schmiegel, W. & Nauck, M. A., Feb 2007, In: Experimental and Clinical Endocrinology and Diabetes. 115, 2, p. 146-50 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Preserved GLP-1 effects in a diabetic patient with Cushing's disease
Ritzel, R. A., Kleine, N., Holst, Jens Juul, Willms, B., Schmiegel, W. & Nauck, M. A., 2007, In: Experimental and Clinical Endocrinology and Diabetes. 115, 2, p. 146-150 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Porcine glucagon-like peptide-2: structure, signaling, metabolism and effects
Pedersen, N. B., Hjøllund, K. R., Johnsen, A. H., Ørskov, Cathrine, Rosenkilde, Mette, Hartmann, B. & Holst, Jens Juul, 2007, In: Regulatory Peptides. 146, 1-3, p. 310-320 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus.
He, Y., Serra, D., Wang, Y., Campestrini, J., Riviere, G., Deacon, Carolyn F., Holst, Jens Juul, Schwartz, S., Nielsen, J. C. & Ligueros-Saylan, M., 2007, In: Clinical Pharmacokinetics. 46, 7, p. 577-88 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT.
He, Y., Wang, Y., Bullock, J. M., Deacon, Carolyn F., Holst, Jens Juul, Dunning, B. E., Ligueros-Saylan, M. & Foley, J. E., 2007, In: Journal of Clinical Pharmacology. 47, 5, p. 633-41 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal
Goldfine, A. B., Mun, E. C., Devine, E., Bernier, R., Baz-Hecht, M., Jones, D. B., Schneider, B. E., Holst, Jens Juul & Patti, M. E., 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 12, p. 4678-4685 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal
Goldfine, A. B., Mun, E. C., Devine, E., Bernier, R., Baz-Hecht, M., Jones, D. B., Schneider, B. E., Holst, Jens Juul & Patti, M. E., Dec 2007, In: The Journal of clinical endocrinology and metabolism. 92, 12, p. 4678-85 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Normal secretion of the incretin hormones glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 during gestational diabetes mellitus
Cypryk, K., Vilsbøll, Tina, Nadel, I., Smyczynska, J., Holst, Jens Juul & Lewinski, A., 2007, In: Gynecological Endocrinology. 23, 1, p. 58-62 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New horizons in diabetes therapy
Holst, Jens Juul & Deacon, Carolyn F., 2007, In: Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 7, 1, p. 49-55 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4207
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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