Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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Effects of intravenous glucagon-like peptide-1 on glucose control and hemodynamics after coronary artery bypass surgery in patients with type 2 diabetes
Müssig, K., Oncü, A., Lindauer, P., Heininger, A., Aebert, H., Unertl, K., Ziemer, G., Häring, H., Holst, Jens Juul & Gallwitz, B., 1 Sep 2008, In: American Journal of Cardiology. 102, 5, p. 646-7 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion
Müssig, K., Staiger, H., Machicao, F., Kirchhoff, K., Guthoff, M., Schäfer, S. A., Kantartzis, K., Silbernagel, G., Stefan, N., Holst, Jens Juul, Gallwitz, B., Häring, H. & Fritsche, A., 2009, In: Diabetes. 58, 7, p. 1715-20 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus
Müssig, K., Staiger, H., Machicao, F., Machann, J., Schick, F., Schäfer, S. A., Claussen, C. D., Holst, Jens Juul, Gallwitz, B., Stefan, N., Fritsche, A. & Häring, H., 2009, In: Metabolism - Clinical and Experimental. 58, 12, p. 1809-11 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Somostatin and Prosomatostatin-immunoreactive nerve fibers in the bovine pineal gland
Møller, M., Mikkelsen, J. D. & Holst, Jens Juul, 1992, In: Neuroendocrinology. Vol. 56 (2), p. 278-283Research output: Contribution to journal › Journal article › Research › peer-review
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Presence of somatostatin containing neuronal-like cells in the rat pineal gland.
Møller, M., Holst, Jens Juul, Mikkelsen, J. D. & Webb, S., 1995, In: Neuroendocrinol. Letters. 17, p. 71-80Research output: Contribution to journal › Journal article › Research › peer-review
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Somatostatin receptors.
Møller, L. N., Stidsen, C. E., Hartmann, B. & Holst, Jens Juul, 2003, In: BBA General Subjects. 1616, 1, p. 1-84 83 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test
Møller, J. B., Jusko, W. J., Gao, W., Hansen, Torben, Pedersen, Oluf Borbye, Holst, Jens Juul, Overgaard, R. V., Madsen, H. & Ingwersen, S. H., 2011, In: Journal of Pharmacokinetics and Pharmacodynamics. 38, 6, p. 713-25 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose-dependent insulinotropic polypeptide (GIP) is associated with lower LDL but unhealthy fat distribution, independent of insulin: The ADDITION-PRO study
Møller, C. L., Vistisen, D., Færch, K., Johansen, N. B., Witte, D. R., Jonsson, Anna Elisabet, Pedersen, Oluf Borbye, Hansen, Torben, Lauritzen, T., Jørgensen, M. E., Torekov, Signe Sørensen & Holst, Jens Juul, Feb 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 2, p. 485– 493 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Prediction of glycemic index in mixed meals
Møller, B. K., Flint, A., Pedersen, D., Raben, A. B., Tetens, I., Holst, Jens Juul & Astrup, A., 2003. 1 p.Research output: Contribution to conference › Paper › Research
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Prolonged successful therapy for hyperinsulinaemic hypoglycaemia after gastric bypass: the pathophysiological role of GLP1 and its response to a somatostatin analogue
Myint, K. S., Greenfield, J. R., Farooqi, I. S., Henning, E., Holst, Jens Juul & Finer, N., 2012, In: European Journal of Endocrinology. 166, 5, p. 951-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of intravenous glucagon-like peptide-1 on glucose control and hemodynamics after coronary artery bypass surgery in patients with type 2 diabetes
Mussig, K., Oncu, A., Lindauer, P., Heininger, A., Aebert, H., Unertl, K., Ziemer, G., Haring, H. U., Gallwitz, B. & Holst, Jens Juul, 2008, In: Journal of the American College of Cardiology. 102, 5, p. 646-647 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of DPP-4 Inhibitor Linagliptin Versus Sulfonylurea Glimepiride as Add-on to Metformin on Renal Physiology in Overweight Patients With Type 2 Diabetes (RENALIS): A Randomized, Double-Blind Trial
Muskiet, M. H. A., Tonneijck, L., Smits, M. M., Kramer, M. H. H., Ouwens, D. M., Hartmann, Bolette, Holst, Jens Juul, Touw, D. J., Danser, A. H. J., Joles, J. A. & van Raalte, D. H., 2020, In: Diabetes Care. 43, 11, p. 2889-2893Research output: Contribution to journal › Journal article › Research › peer-review
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Postprandial renal hemodynamic effects of DPP-4 inhibitor linagliptin versus sulfonylurea glimepiride in adults with type 2 diabetes (RENALIS): a pre-defined sub-study of a randomized, double-blind trial
Muskiet, M. H. A., Tonneijck, L., Smits, M. M., Kramer, M. H. H., Ouwens, D. M., Hartmann, Bolette, Holst, Jens Juul, Danser, A. H. J., Joles, J. A. & van Raalte, D. H., 2022, In: Diabetes, Obesity and Metabolism. 24, 1, p. 115-124Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes
Muscogiuri, G., DeFronzo, R. A., Gastaldelli, A. & Holst, Jens Juul, Feb 2017, In: Trends in Endocrinology and Metabolism. 28, 2, p. 88-103 16 p.Research output: Contribution to journal › Review › Research › peer-review
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Gut: a key player in the pathogenesis of type 2 diabetes?
Muscogiuri, G., Balercia, G., Barrea, L., Cignarelli, A., Giorgino, F., Holst, Jens Juul, Laudisio, D., Orio, F., Tirabassi, G. & Colao, A., 2018, In: Critical Reviews in Food Science and Nutrition. 58, 8, p. 1294–1309Research output: Contribution to journal › Review › Research › peer-review
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Removal of Duodenum Elicits GLP-1 Secretion
Muscogiuri, G., Mezza, T., Prioletta, A., Sorice, G. P., Clemente, G., Sarno, G., Nuzzo, G., Pontecorvi, A., Holst, Jens Juul & Giaccari, A., 7 Feb 2013, In: Diabetes Care. 36, 6, p. 1641-1646 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance
Muscelli, E., Mari, A., Natali, A., Astiarraga, B. D., Camastra, S., Frascerra, S., Holst, Jens Juul & Ferrannini, E., Dec 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 6, p. E1144-50Research output: Contribution to journal › Journal article › Research › peer-review
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Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients
Muscelli, E., Mari, A., Casolaro, A., Camastra, S., Seghieri, G., Gastaldelli, A., Holst, Jens Juul & Ferrannini, E., May 2008, In: Diabetes. 57, 5, p. 1340-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes
Muscelli, E., Casolaro, A., Gastaldelli, A., Mari, A., Seghieri, G., Astiarraga, B., Chen, Y., Alba, M., Holst, Jens Juul & Ferrannini, E., Aug 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 8, p. 2818-26 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance
Muscelli, E., Mari, A., Natali, A., Astiarraga, B. D., Camastra, S., Frascerra, S., Holst, Jens Juul & Ferrannini, E., 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 6, p. E1144-E1150Research output: Contribution to journal › Journal article › Research › peer-review
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Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients
Muscelli, E., Mari, A., Casolaro, A., Camastra, S., Seghieri, G., Gastaldelli, A., Holst, Jens Juul & Ferrannini, E., 2008, In: Diabetes. 57, 5, p. 1340-1348 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor
Murphy, R., Tura, A., Clark, P. M., Holst, Jens Juul, Mari, A. & Hattersley, A. T., 2008, In: Diabetologia. 52, 1, p. 154-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Defects in α-Cell Function in Patients With Diabetes Due to Chronic Pancreatitis Compared With Patients With Type 2 Diabetes and Healthy Individuals
Mumme, L., Breuer, T. G. K., Rohrer, S., Schenker, N., Menge, B. A., Holst, Jens Juul, Nauck, M. A. & Meier, J. J., Oct 2017, In: Diabetes Care. 40, 10, p. 1314-1322 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of wheat bran derived prebiotic supplementation on gastrointestinal transit, gut microbiota, and metabolic health: a randomized controlled trial in healthy adults with a slow gut transit
Muller, M., Hermes, G. D. A., Canfora, E. E., Holst, Jens Juul, Zoetendal, E. G., Smidt, H., Troost, F., Schaap, F. G., Damink, S. O., Jocken, J. W. E., Lenaerts, K., Masclee, A. A. M. & Blaak, E. E., 2020, In: Gut Microbes. 12, 1, 15 p., e1704141.Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans
Muller, M., Hernandez, M. A. G., Goossens, G. H., Reijnders, D., Holst, Jens Juul, Jocken, J. W. E., van Eijk, H., Canfora, E. E. & Blaak, E. E., 2019, In: Scientific Reports. 9, 9 p., 12515.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia
Mulla, C. M., Goldfine, A. B., Dreyfuss, J. M., Houten, S., Pan, H., Pober, D. M., Albrechtsen, Nicolai Jacob Wewer, Svane, M. S., Schmidt, J. B., Holst, Jens Juul, Craig, C. M., McLaughlin, T. L. & Patti, M., 2019, In: Obesity Surgery. 29, 7, p. 2092-2099Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide 1 (GLP-1)
Mueller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., Holst, J. J., Langhans, W., Meier, J. J., Nauck, M. A., Perez-Tilve, D., Pocai, A., Reimann, F., Sandoval, D. A., Schwartz, T. W., Seeley, R. J. & 5 others, , 2019, In: Molecular Metabolism. 30, p. 72-130Research output: Contribution to journal › Review › Research › peer-review
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β-Lactoglobulin Is Insulinotropic Compared with Casein and Whey Protein Ingestion during Catabolic Conditions in Men in a Double-Blinded Randomized Crossover Trial
Mose, M., Møller, N., Jessen, N., Mikkelsen, U. R., Christensen, B., Rakvaag, E., Hartmann, Bolette, Holst, Jens Juul, Jørgensen, J. O. L. & Rittig, N., 2021, In: Journal of Nutrition. 151, 6, p. 1462-1472 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Metabolic effects of beta-lactoglobulin, casein and whey supplementations during controlled catabolic inflammation in humans
Mose, M., Moller, N., Jessen, N., Mikkelsen, U. R., Christensen, B., Raakvaag, E., Holst, Jens Juul, Jørgensen, J. L. & Rittig, N., 2020, In: Diabetologia. 63, SUPPL 1, p. S240-S240 1 p., 496.Research output: Contribution to journal › Conference abstract in journal › Research
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Glucose homeostasis in statin users-The LIFESTAT study
Morville, T., Dohlmann, T., Kuhlman, A. B., Monberg, T., Torp, M., Hartmann, Bolette, Holst, Jens Juul, Larsen, Steen, Helge, Jørn Wulff & Dela, Flemming, 2019, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 35, 3, 9 p., e3110.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: comparison of whey, casein, gluten, and cod protein
Mortensen, L. S., Hartvigsen, M. L., Brader, L. J., Astrup, A., Schrezenmeir, J., Holst, Jens Juul, Thomsen, C. & Hermansen, K., 2009, In: American Journal of Clinical Nutrition. 90, 1, p. 41-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes
Mortensen, L. S., Holmer-Jensen, J., Hartvigsen, M., Jensen, V. K., Astrup, A., Vrese, M. D., Holst, Jens Juul, Thomsen, C. H. P. & Hermansen, K., 2012, In: European Journal of Clinical Nutrition. 66, 7, p. 799-805 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine
Mortensen, K., Christensen, L. L., Holst, Jens Juul & Ørskov, Cathrine, 2003, In: Regulatory Peptides. 114, 2-3, p. 189-96 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Short communication: Promotion of glucagon-like peptide-2 secretion in dairy calves with a bioactive extract from Olea europaea
Morrison, S. Y., Pastor, J. J., Quintela, J. C., Holst, Jens Juul, Hartmann, Bolette, Drackley, J. K. & Ipharraguerre, I. R., 1 Mar 2017, In: Journal of Dairy Science. 100, 3, p. 1940-1945 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Resistant starch combined with whey protein increases postprandial metabolism and lowers glucose and insulin responses in healthy adult men
Mohr, A. E., Minicucci, O., Long, D., Miller, V. J., Keller, A., Sheridan, C., O’brien, G., Ward, E., Schuler, B., Connelly, S., Holst, Jens Juul, Astrup, A., He, F., Gentile, C. L. & Arciero, P. J., 2021, In: Foods. 10, 3, 17 p., 537.Research output: Contribution to journal › Journal article › Research › peer-review
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Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms
Modvig, Ida Marie, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Xu, S., Engelstoft, M. S., Egerod, Kristoffer Lihme, Schwartz, Thue W., Ørskov, Cathrine, Rosenkilde, Mette & Holst, Jens Juul, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, p. E874-E885 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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L-valine is a powerful stimulator of GLP-1 secretion in rodents and stimulates secretion through ATP-sensitive potassium channels and voltage-gated calcium channels
Modvig, Ida Marie, Smits, Mark, Galsgaard, Katrine Douglas, Hjørne, A. P., Drzazga, Anna Katarzyna, Rosenkilde, Mette & Holst, Jens Juul, 2024, In: Nutrition and Diabetes. 14, 11 p., 43.Research output: Contribution to journal › Journal article › Research › peer-review
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Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine
Modvig, Ida Marie, Andersen, Daniel Bjørklund, Grunddal, Kaare Villum, Kuhre, Rune Ehrenreich, Martinussen, C., Christiansen, Charlotte Bayer, Ørskov, Cathrine, Larraufie, P., Kay, R. G., Reimann, F., Gribble, F. M., Hartmann, Bolette, Bojsen-Moller, K. N., Madsbad, Sten, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2020, In: International Journal of Obesity. 44, 9, p. 1859-1871Research output: Contribution to journal › Journal article › Research › peer-review
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Peptone-mediated glucagon-like peptide-1 secretion depends on intestinal absorption and activation of basolaterally located Calcium-Sensing Receptors
Modvig, Ida Marie, Kuhre, Rune Ehrenreich & Holst, Jens Juul, Apr 2019, In: Physiological Reports. 7, 8, 13 p., e14056.Research output: Contribution to journal › Journal article › Research › peer-review
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CCK-1 and CCK-2 receptor agonism do not stimulate GLP-1 and neurotensin secretion in the isolated perfused rat small intestine or GLP-1 and PYY secretion in the rat colon
Modvig, Ida Marie, Christiansen, Charlotte Bayer, Rehfeld, Jens Frederik, Holst, Jens Juul & Veedfald, Simon, 2020, In: Physiological Reports. 8, 2, 8 p., 14352.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans
Modrzynska, J., Klein, C. F., Iversen, Kasper, Bundgård, Henning, Hartmann, Bolette, Mose, M., Rittig, N., Møller, N., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Endocrine Connections. 10, 2, p. 205-213 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of gastric inhibitory polypeptide signaling prevents obesity.
Miyawaki, K., Yamada, Y., Ban, N., Ihara, Y., Tsukiyama, K., Zhou, H., Fujimoto, S., Oku, A., Tsuda, K., Toyokuni, S., Hiai, H., Mizunoya, W., Fushiki, T., Holst, J. J., Makino, M., Tashita, A., Kobara, Y., Tsubamoto, Y., Jinnouchi, T., Jomori, T. & 1 others, , 2002, In: Nature Medicine. 8, 7, p. 738-42 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Circadian rhythms of GIP and GLP1 in glucose-tolerant and in type 2 diabetic patients after biliopancreatic diversion
Mingrone, G., Nolfe, G., Gissey, G. C., Iaconelli, A., Leccesi, L., Guidone, C., Nanni, G. & Holst, Jens Juul, 2009, In: Diabetologia. 52, 5, p. 873-81 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gut microbiota may have influence on glucose and lipid metabolism.
Mikkelsen, K. H., Nielsen, M. F., Tvede, M., Hansen, Torben, Pedersen, Oluf Borbye, Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, 11 Nov 2013, In: Ugeskrift for Laeger. 175, 46, p. 2785-2788 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course
Mikkelsen, K. H., Vilsbøll, Tina, Holst, Jens Juul, Hartmann, Bolette, Knop, Filip Krag & Frost, M., 2018, In: BMC Endocrine Disorders. 18, 6 p., 60.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of Antibiotics on Gut Microbiota, Gut Hormones and Glucose Metabolism
Mikkelsen, K. H., Frost, M., Bahl, M. I., Licht, T. R., Jensen, U. S., Rosenberg, Jacob, Pedersen, Oluf Borbye, Hansen, Torben, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, T. & Knop, Filip Krag, 12 Nov 2015, In: PLOS ONE. 10, 11, p. 1-14 e0142352.Research output: Contribution to journal › Journal article › Research › peer-review
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Nerve fibers in the rat posterior pituitary lobe contain Prosomatostatin (1-64)
Mikkelsen, J. D., Bersani, M., Holst, Jens Juul & Larsen, P. J., 1991, In: Neuroendocrinology. 54, p. 469-476Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility.
Miki, T., Minami, K., Shinozaki, H., Matsumura, K., Saraya, A., Ikeda, H., Yamada, Y., Holst, Jens Juul & Seino, S., 2005, In: Diabetes. 54, 4, p. 1056-63 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Emptying of the Gastric Substitute, Glucagon-like Peptide-1 (GLP-1), and Reactive hypoglycemia after Total Gastrectomy
Miholic, J., Ørskov, C., Holst, Jens Juul, Kotzerke, J. & Meyer, H. J., 1991, In: Digestive Diseases and Sciences. 36, no.10, p. 1361-1370Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1 (GLP-1), Entleerung des Magenersatzes und das Dumpingsyndrom nach Gastrektomie
Miholic, J., Ørskov, C., Holst, Jens Juul, Meyer, H. & Pichlmayr, R., 1991, In: Langerbecks Archiv für Chirurgie. (108. Kongress der Deutsch.Gesellsch.Chirurgie. Suppl.1991, p. 430-432Research output: Contribution to journal › Journal article › Research › peer-review
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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