Birgitte Holst

Birgitte Holst

Guest Researcher


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  1. Published

    Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor

    Holst, Birgitte, Lang, M., Brandt, E., Bach, Anders, Howard, A., Frimurer, T. M., Beck-Sickinger, A. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 3, p. 936-46 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Ghrelin receptor mutations--too little height and too much hunger

    Holst, Birgitte & Schwartz, Thue W., 2006, In: Journal of Clinical Investigation. 116, 3, p. 637-41 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Ghrelin-mediated improvements in the metabolic phenotype in the R6/2 mouse model of Huntington's disease

    Rudenko, Olga, Springer, C., Skov, Louise Julie, Madsen, A. N., Hasholt, Lis Frydenreich, Nørremølle, Anne & Holst, Birgitte, 2019, In: Journal of Neuroendocrinology. 31, 7 (SI), 14 p., e12699.

    Research output: Contribution to journal › Conference article › Research › peer-review

  4. Published

    Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo

    Barington, M., Brorson, M. M., Hofman-Bang, J., Rasmussen, Å. K., Holst, Birgitte & Feldt-Rasmussen, Ulla, 2017, In: PloS one. 12, 9, 13 p., e0184992.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Hepatic NAD+ levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL/6JBomTac mice

    Dall, M., Penke, M., Sulek, K., Matz-Soja, M., Holst, Birgitte, Garten, A., Kiess, W. & Treebak, Jonas Thue, 2018, In: Molecular and Cellular Endocrinology. 473, p. 245-256 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist

    Holst, Birgitte, Cygankiewicz, A., Jensen, T. H., Ankersen, M. & Schwartz, Thue W., 2003, In: Molecular Endocrinology. 17, 11, p. 2201-10 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice

    Thieme, V., Jolly, N., Madsen, A. N., Bellmann-Sickert, K., Schwartz, Thue W., Holst, Birgitte, Cox, H. M. & Beck-Sickinger, A. G., Nov 2016, In: British Journal of Pharmacology. 173, 22, p. 3208-3221 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis

    Johnsen, Cecilie Hundahl, Kotzbeck, P., Burm, Hayley Beth, Christiansen, S. H., Pedersen, Lola Julie Torz, zmw799, zmw799, Madsen, M. P., Ratner, C., Serup, A. K., Thompson, J. J., Eichmann, T. O., Pers, Tune H, Woldbye, David Paul Drucker, Piomelli, D., Kiens, Bente, Zechner, R., Skov, Louise Julie & Holst, Birgitte, 2021, In: Molecular Metabolism. 47, 16 p., 101174.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Identification and Metabolic Profiling of a Novel Human Gut-derived LEAP2 Fragment

    Hagemann, C. A., Zhang, C., Hansen, H. H., Jorsal, T., Rigbolt, K. T. G., Madsen, M. R., Bergmann, N. C., Heimbürger, S. M. N., Falkenhahn, M., Theis, S., Breitschopf, K., Holm, Stephanie Kjærulff, Hedegaard, M. A., Christensen, Mikkel Bring, Vilsbøll, Tina, Holst, Birgitte, Vrang, N., Jelsing, J. & Knop, Filip Krag, 2021, In: The Journal of clinical endocrinology and metabolism. 106, 2, p. e966-e981

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism

    Holst, Birgitte, Mokrosinski, J., Lang, M., Brandt, E., Nygaard, R., Frimurer, T. M., Beck-Sickinger, A. G. & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 21, p. 15799-811 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder

    Młyniec, K., Trojan, E., Ślusarczyk, J., Głombik, K., Basta-Kaim, A., Budziszewska, B., Skrzeszewski, J., Siwek, A., Holst, Birgitte & Nowak, G., 15 Feb 2016, In: Journal of Neuroimmunology. 291, p. 11-17 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Impaired glucose metabolism and altered gut microbiome despite calorie restriction of ob/ob mice

    Kashani, A., Brejnrod, A. D., Jin, C., Kern, T., Madsen, A. N., Holm, L. A., Gerber, G. K., Holm, Jens-Christian, Hansen, Torben, Holst, Birgitte & Arumugam, Mani, 2019, In: Animal Microbiome. 1, 1, 16 p., 11.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity

    Ratner, C., Madsen, A. N., Kristensen, L. V., Skov, Louise Julie, Pedersen, K. S., Mortensen, Ole Hartvig, Knudsen, Gitte Moos, Raun, K. & Holst, Birgitte, 8 Apr 2015, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 308, 11, p. R973-R982 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor

    Holliday, N. D., Holst, Birgitte, Rodionova, E. A., Schwartz, Thue W. & Cox, H. M., 2007, In: Molecular Endocrinology. 21, 12, p. 3100-12 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36

    Pedersen, S. L., Bhatia, V. K., Jurt, S., Paulsson, J. F., Pedersen, M. H., Jørgensen, R., Holst, Birgitte, Stamou, Dimitrios, Vrang, N., Zerbe, O. & Jensen, Knud Jørgen, 2012, In: Journal of Peptide Science. 18, 9, p. 579-587 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist

    Lückmann, Michael, Holst, Birgitte, Schwartz, Thue W. & Frimurer, Thomas Michael, 2016, In: Molecular Informatics. 35, p. 19-24 6 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  17. Published

    In vivo characterization of high Basal signaling from the ghrelin receptor

    Petersen, P. S., Woldbye, David Paul Drucker, Madsen, A. N., Egerod, Kristoffer Lihme, Jin, C., Lang, M., Rasmussen, M., Beck-Sickinger, A. G. & Holst, Birgitte, 2009, In: Endocrinology. 150, 11, p. 4920-30 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Increased meal-induced neurotensin response predicts successful maintenance of weight loss: Data from a randomized controlled trial

    Brethvad, Annemette Overgaard, Zakariassen, Hannah Louise, Holt, Joachim, Lundgren, J. R., Jakobsen, A., Hartmann, Bolette, Lehmann, E. W., Kissow, Hannelouise, Holst, Jens Juul, Madsbad, Sten, Torekov, Signe Sørensen & Holst, Birgitte, 2023, In: Metabolism: Clinical and Experimental. 143, 8 p., 155534.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice

    Clemmensen, Christoffer, Smajilovic, S., Madsen, A. N., Klein, A. B., Holst, Birgitte & Bräuner, Hans, 2013, In: Journal of Endocrinology. 217, 2, p. 151-60 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor

    Deschaine, S. L., Hedegaard, M. A., Pince, C. L., Farokhnia, M., Moose, J. E., Stock, I. A., Adusumalli, S., Akhlaghi, F., Hougland, J. L., Sulima, A., Rice, K. C., Koob, G. F., Vendruscolo, L. F., Holst, Birgitte & Leggio, L., 2023, In: Journal of Pharmacology and Experimental Therapeutics. 386, 2, p. 117-128 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission

    Młyniec, K., Gaweł, M., Librowski, T., Reczyński, W., Bystrowska, B. & Holst, Birgitte, Jun 2015, In: Brain Research Bulletin. 115, p. 23-29 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Ketone monoester increases circulating levels of LEAP2 and decreases appetite in healthy men

    Holm, Stephanie Kjærulff, Vestergaard, E. T., Zubanovic, N. B., Byberg, Sarah, Clemmensen, Christoffer, Holst, Birgitte & Thomsen, H. H., 2023, In: Diabetes, Obesity and Metabolism. 25, 7, p. :2023–2027

    Research output: Contribution to journal › Letter › Research › peer-review

  23. Published

    L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances

    Clemmensen, Christoffer, Madsen, A. N., Smajilovic, S., Holst, Birgitte & Bräuner, Hans, 2012, In: Amino Acids. 43, 3, p. 1265-1275

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    LEAP2 is associated with cardiometabolic markers but is unchanged by antidiabetic treatment in people with prediabetes

    Byberg, Sarah, Blond, Martin Bæk, Holm, Stephanie Kjærulff, Amadid, H., Nielsen, L. B., Clemmensen, K. K. B., Færch, K. & Holst, Birgitte, 2023, In: American journal of physiology. Endocrinology and metabolism. 325, 3, p. E244-E251

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men

    Hagemann, C. A., Jensen, M. S., Holm, Stephanie Kjærulff, Gasbjerg, Lærke Smidt, Byberg, Sarah, Skov-Jeppesen, Kirsa, Hartmann, Bolette, Holst, Jens Juul, Dela, Flemming, Vilsbøll, Tina, Christensen, Mikkel Bring, Holst, Birgitte & Knop, Filip Krag, 2022, In: Cell Reports Medicine. 3, 4, 100582.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Ligand binding and micro-switches in 7TM receptor structures

    Nygaard, R., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Schwartz, Thue W., 2009, In: TIPS - Trends in Pharmacological Sciences. 30, 5, p. 249-59 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway

    Ratner, C., He, Z., Grunddal, Kaare Villum, Skov, Louise Julie, Hartmann, Bolette, Zhang, F., Feuchtinger, A., Bjerregaard, Anette, Christoffersen, Christina, Tschöp, M. H., Finan, B., DiMarchi, R. D., Leinninger, G. M., Williams, K. W., Clemmensen, Christoffer & Holst, Birgitte, 2019, In: Diabetes. 68, 6, p. 1329-1340

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation

    Bellmann-Sickert, K., Elling, C. E., Madsen, A. N., Little, P. B., Lundgren, K., Gerlach, L., Bergmann, R., Holst, Birgitte, Schwartz, Thue W. & Beck-Sickinger, A. G., 2011, In: Journal of Medicinal Chemistry. 54, 8, p. 2658-67 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans

    Andersson, E. A., Holst, Birgitte, Sparsø, T., Grarup, Niels, Banasik, Karina, Holmkvist, J., Jørgensen, T., Borch-Johnsen, K., Egerod, Kristoffer Lihme, Lauritzen, T., Sørensen, Thorkild I.A., Bonnefond, A., Meyre, D., Froguel, P., Schwartz, Thue W., Pedersen, Oluf Borbye & Hansen, Torben, 2010, In: Diabetes. 59, 6, p. 1539-48 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Melanocortin 4 receptor mutations in obese Czech children: Studies of prevalence, phenotype development, weight reduction response, and functional analysis

    Hainerova, I., Larsen, L. H., Holst, Birgitte, Finkova, M., Hainer, V., Lebl, J., Hansen, T. & Pedersen, O., 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 9, p. 3689-3696 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Metabolic insights from a GHSR-A203E mutant mouse model

    Pedersen, Lola Julie Torz, Osborne-Lawrence, S., Rodriguez, J., He, Z., Paula Cornejo, M., Roman Mustafa, E., Jin, C., Petersen, N., Hedegaard, M. A., Nybo, Maja Lind, Martinez Damonte, V., Metzger, N. P., Mani, B. K., Williams, K. W., Raingo, J., Perello, M., Holst, Birgitte & Zigman, J. M., 2020, In: Molecular Metabolism. 39, 16 p., 101004.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation

    Elling, C. E., Frimurer, T. M., Gerlach, L., Jorgensen, R., Holst, Birgitte & Schwartz, Thue W., 2006, In: Journal of Biological Chemistry. 281, 25, p. 17337-46 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors

    Holst, Birgitte, Elling, C. E. & Schwartz, Thue W., 2002, In: Journal of Biological Chemistry. 277, 49, p. 47662-70 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions.

    Frimurer, Thomas Michael, Mende, F., Graae, A., Engelstoft, M. S., Egerod, Kristoffer Lihme, Nygaard, R., Gerlach, L., Hansen, J. B., Schwartz, Thue W. & Holst, Birgitte, 2017, In: Journal of Medicinal Chemistry. 60, 3, p. 886-898 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Modifying the conserved C-terminal tyrosine of the peptide hormone PYY3-36 to improve Y2 receptor selectivity

    Pedersen, S. L., Holst, Birgitte, Vrang, N. & Jensen, Knud Jørgen, 2009, In: Journal of Peptide Science. 15, 11, p. 753-759 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop

    Mokrosinski, J., Frimurer, Thomas Michael, Sivertsen, B., Schwartz, Thue W. & Holst, Birgitte, Sep 2012, In: Journal of Biological Chemistry. 287, p. 33488-33502 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Modulation of the constitutive activity of the ghrelin receptor by use of pharmacological tools and mutagenesis

    Mokrosinski, J. & Holst, Birgitte, Jan 2010, In: Methods in Enzymology. 484, p. 53-73 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Molecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII

    Gbahou, F., Holst, Birgitte & Schwartz, Thue W., 2010, In: Journal of Pharmacology and Experimental Therapeutics. 333, 1, p. 51-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Molecular mechanism of 7TM receptor activation--a global toggle switch model

    Schwartz, Thue W., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Elling, C. E., 2006, In: Annual Review of Pharmacology and Toxicology. 46, p. 481-519 38 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39

    Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: FEBS Letters. 582, 17, p. 2583-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe

    Holst, Birgitte & Schwartz, Thue W., 2003, In: Annals of the New York Academy of Sciences. 994, p. 1-11 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Molecular structure and function of 7TM/G-protein coupled receptors

    Schwartz, Thue W. & Holst, Birgitte, 2002, Textbook of receptor Pharmacology. p. 65-84

    Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research

  43. Published

    NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype

    Martini, L., Hastrup, H., Holst, Birgitte, Fraile-Ramos, A., Marsh, M. & Schwartz, Thue W., 2002, In: Molecular Pharmacology. 62, 1, p. 30-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor

    Rosenkilde, Mette, Lucibello, M., Holst, Birgitte & Schwartz, Thue W., 1998, In: FEBS Letters. 439, 1-2, p. 35-40 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Neprilysin activity is increased in metabolic dysfunction-associated steatotic liver disease and normalizes after bariatric surgery or GLP-1 therapy

    Kjeldsen, S. A. S., Gluud, L. L., Werge, M. P., Pedersen, J. S., Bendtsen, F., Alexiadou, K., Tan, T., Torekov, S. S., Iepsen, E. W., Jensen, N. J., Richter, M. M., Goetze, J. P., Rungby, J., Hartmann, B., Holst, J. J., Holst, B., Holt, J., Gustafsson, F., Madsbad, S., Svane, M. S. & 2 others, Bojsen-Møller, K. N. & Albrechtsen, Nicolai Jacob Wewer, 2023, In: iScience. 26, 11, 13 p., 108190.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Neuromedin U inhibits food intake partly by inhibiting gastric emptying

    Dalbøge, L. S., Pedersen, S. L., Secher, T., Holst, Birgitte, Vrang, N. & Jelsing, J., Jul 2015, In: Peptides. 69, p. 56-65 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Neurotensin Is Co-Expressed, Co-Released And Acts Together With Glp-1 And Pyy In Enteroendocrine Control Of Metabolism

    Grunddal, Kaare Villum, Ratner, C. F., Svendsen, B., Sommer, F., Engelstoft, M. S., Madsen, A. N., Pedersen, Jens, Nøhr, M. K., Egerod, Kristoffer Lihme, Nawrocki, A. R., Kowalski, T., Howard, A. D., Poulsen, Steen Seier, Offermanns, S., Bäckhed, G. F., Holst, Jens Juul, Holst, Birgitte & Schwartz, Thue W., Jan 2016, In: Endocrinology. 157, 1, p. 176-94 19 p., en20151600.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    New potential agents for cryopreservation of hematopoietic and adipose stromal cells

    Svalgaard, J., Haastrup, E., Brink, A., Clausen, C., Holst, Birgitte, Theilgaard-Mønch, Kim, Reckzeh, K. & Fischer-Nielsen, A., Apr 2014, In: Cytotherapy. 16, Supplement 4, p. S58

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  49. Published

    Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling

    Holst, Birgitte, Brandt, E., Bach, Anders, Heding, A. & Schwartz, Thue W., 2005, In: Molecular Endocrinology. 19, 9, p. 2400-11 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor

    Holst, Birgitte, Frimurer, T. M., Mokrosinski, J., Halkjaer, T., Cullberg, K. B., Underwood, C. R. & Schwartz, Thue W., 2008, In: Molecular Pharmacology. 75, 1, p. 44-59 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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