Jens Juul Holst

Jens Juul Holst

Professor


  1. 2002
  2. Published

    Short-term administration of Glucagon-like peptide-2. Effects on bone mass density and markers of bone remodelling in short bowel patients with no colon

    Haderslev, K. V., Jeppesen, P. B., Hartmann, B., Thulesen, J., Sørensen, H. A., Graff, J., Hansen, B. S., Tofteng, F., Poulsen, Steen Seier, Madsen, J. L., Holst, Jens Juul, Staun, M. & Mortensen, P. B., 2002, In: Scandinavian Journal of Gastroenterology. vol. 37, p. 392-398

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist.

    Thulesen, J., Knudsen, L. B., Hartmann, B., Hastrup, S., Kissow, Hannelouise, Jeppesen, P. B., Ørskov, Cathrine, Holst, Jens Juul & Poulsen, Steen Seier, 2002, In: Regulatory Peptides. 103, 1, p. 9-15 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1.

    Holst, Jens Juul, 2002, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 18, 6, p. 430-41 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs

    Deacon, Carolyn F., Wamberg, S., Bie, P., Hughes, T. E. & Holst, Jens Juul, Feb 2002, In: Journal of Endocrinology. 172, 2, p. 355-62 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Abnormal release of incretins and cortisol after oral glucose in subjects with insulin-resistant myotonic dystrophy

    Johansson, A., Olsson, T., Cederquist, K., Forsberg, H., Holst, Jens Juul, Seckl, J. R. & Ahren, B., Mar 2002, In: European Journal of Endocrinology. Supplement. 146, 3, p. 397-405 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers

    Nauck, M. A., Heimesaat, M. M., Behle, K., Holst, Jens Juul, Nauck, M. S., Ritzel, R., Hüfner, M. & Schmiegel, W. H., Mar 2002, In: The Journal of clinical endocrinology and metabolism. 87, 3, p. 1239-46 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Effects of topical ropivacaine on eicosanoids and neurotransmitters in the rectum of patients with distal ulcerative colitis

    Hillingsø, Jens Georg, Kjeldsen, J., Schmidt, P. T., Rasmussen, T. N., Fisher-Hansen, B., Holst, Jens Juul, Lauristen, K., Bukhave, K. & Rask-Madsen, J., Mar 2002, In: Scandinavian Journal of Gastroenterology. 37, 3, p. 325-9 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon

    Haderslev, Kent Valentin, Jeppesen, Palle Bekker, Hartmann, Bolette, Thulesen, J., Sorensen, H. A., Graff, J., Tofteng, F., Poulsen, S. S., Madsen, J. L., Holst, Jens Juul, Staun, Michael, Mortensen, P. B. & Poulsen, Steen Seier, 1 Apr 2002, In: Scandinavian Journal of Gastroenterology. 37, 4, p. 392-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice

    Reimer, M. K., Holst, Jens Juul & Ahrén, B., May 2002, In: European Journal of Endocrinology. Supplement. 146, 5, p. 717-27 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion

    Djurhuus, C. B., Hansen, T. K., Gravholt, C., Ørskov, L., Hosoda, H., Kangawa, K., Jørgensen, J. O. L., Holst, Jens Juul & Schmitz, O., Jul 2002, In: Hormone and Metabolic Research. Supplement. 34, 7, p. 411-3 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Feast or famine - are GLP-1 and ghrelin secretion intertwined?

    Djurhuus, C. B., Hansen, T. K., Holst, Jens Juul & Schmitz, O., Jul 2002, In: Hormone and Metabolic Research. Supplement. 34, 7, p. 353-4 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

    Zhu, X., Zhou, A., Dey, A., Norrbom, C., Carroll, R., Zhang, C., Laurent, V., Lindberg, I., Ugleholdt, Randi Kjærsgaard, Holst, Jens Juul & Steiner, D. F., 6 Aug 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 16, p. 10293-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Anti-diabetogenic effect of the human amylin analogue, pramlintide, in Type 1 diabetes is not mediated by GLP-1

    Ahrén, B., Adner, N., Svartberg, J., Petrella, E., Holst, Jens Juul & Gutniak, M. K., Sep 2002, In: Diabetic Medicine. 19, 9, p. 790-2 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Repaglinide at a cellular level

    Krogsgaard Thomsen, M., Bokvist, K., Høy, M., Buschard, K., Holst, Jens Juul, Lindström, P. & Gromada, J., Dec 2002, In: Diabetes, nutrition & metabolism. 15, 6 Suppl, p. 15-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop?

    Hansen, L. & Holst, Jens Juul, 31 Dec 2002, In: Regulatory Peptides. 110, 1, p. 39-45 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2003
  18. Published

    Absence of a memory effect for the insulinotropic action of glucagon-like peptide 1(GLP-1) in healthy volunteers

    Meier, S., Hücking, K., Ritzelt, R., Holst, Jens Juul, Schmiegel, W. H. & Nauck, M. A., 2003, In: Horm Metab Res. 35, p. 551-556

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Characterization of GLP-1 effects on beta cell function after meal ingestion in humans

    Ahren, B., Holst, Jens Juul & Mari, A., 2003, In: Diabetes Care. 26, p. 2860-2864

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Circulating leptin and thyroid dysfunction.

    Zimmermann-Belsing, T., Brabant, G., Holst, Jens Juul & Feldt-Rasmussen, Ulla, 2003, In: European Journal of Endocrinology. 149, 4, p. 257-71 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Cocaine and amphetamine-regulated transcript (CART) is present in hypothalamic neuroendocrine neurons and is related to the hypothalamo-pituitary portal circuit

    Larsen, P. J., Seier, V., Fink-Jensen, A., Holst, Jens Juul, Warberg, J. & Vrang, N., 2003, In: Journal of Neuroendocrinology. 15, p. 219-226

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease.

    Piche, T., des Varannes, S. B., Sacher-Huvelin, S., Holst, Jens Juul, Cuber, J. C. & Galmiche, J. P., 2003, In: Gastroenterology. 124, 4, p. 894-902 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Comparisons of leptin, incretins and body composition in obese and lean patients with hypopituitarism and healthy individuals

    Mersebach, H., Svendsen, Ole Lander, Holst, Jens Juul, Astrup, A. & Feldt-Rasmussen, Ulla, 2003, In: Clinical Endocrinology. 58, 1, p. 65-71 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Differential effects of saturated and monounsaturated fat on postprandial lipemia and incretin responses in type 2 diabetic subjects

    Thomsen, C., Storm, H., Holst, Jens Juul & Hermansen, K., 2003, In: Am. J. Clin. Nutr.. 77, p. 605-611

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Differential regional metabolism of glucagon in anesthetized pigs.

    Deacon, Carolyn F., Kelstrup, M., Trebbien, R., Klarskov, L., Olesen, M. & Holst, Jens Juul, 2003, In: American Journal of Physiology: Endocrinology and Metabolism. 285, 3, p. E552-60

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Does overnight normalization of plasma glucose by insulin infusion affect assessment of glucose metabolism in type 2 diabetes

    Staehr, P., Højlund, K., Hother-Nielsen, O., Holst, Jens Juul & Beck-Nielsen, H., 2003, In: Diabetic Medicine. 20, p. 816-822

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Effects of GLP-2 treatment and antibiotics on gut structure and function during pig weanling diarrhea

    Nielsen, T. T., Sangild, Per Torp, Elnif, J., Sorensen, K., Leser, T., Holst, Jens Juul, Hartmann, B., Jensen, B. B. & Hedemann, M. S., 2003, Ikke angivet. R.O. Ball (ed.). 2 ed. University of Alberta Press, p. 161-163 3 p.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearch

  28. Published

    Effects of free fatty acids per se on glucose production, gluconeogenesis, and glycogenolysis.

    Staehr, P., Hother-Nielsen, O., Landau, B. R., Chandramouli, V., Holst, Jens Juul & Beck-Nielsen, H., 2003, In: Diabetes. 52, 2, p. 260-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Et æble om dagen

    Larsen, P. J., Holst, Jens Juul & Astrup, A., 2003, In: Politiken. 29, 2 p.

    Research output: Contribution to journalContribution to newspaper - Feature articleCommunication

  30. Published

    Exogenous GLP-2 has only marginal effects on weaning-induced intestinal adaption in piglets

    le Huërou-Luron, I., Petersen, Y. M., Hartmann, B., Holst, Jens Juul & Sangild, Per Torp, 2003, Ikke angivet. R.O. Ball (ed.). 2 ed. University of Alberta Press, p. 164-166 3 p.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearch

  31. Published

    Functional and immunohistochemical evaluation of porcine neonatal islet-like cell clusters.

    Nielsen, T. B., Yderstraede, K. B., Schrøder, H. D., Holst, Jens Juul, Brusgaard, K. & Beck-Nielsen, H., 2003, In: Cell Transplantation. 12, 1, p. 13-25 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine

    Mortensen, K., Christensen, L. L., Holst, Jens Juul & Ørskov, Cathrine, 2003, In: Regulatory Peptides. 114, 2-3, p. 189-96 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    GLP-2 mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TNP-fed piglets

    Guan, X., Stoll, B., Lu, X., Tappenden, K., Holst, Jens Juul, Hartmann, B. & Burrin, D. G., 2003, In: Today in Medicine. Gastroenterology. 125, p. 136-147

    Research output: Contribution to journalJournal articleResearch

  34. Published

    Gastric inhibitory polypeptide (GIP) does not inhibit gastric emptying in man

    Meier, J. M., Goetze, O., Anstipp, J., Hagemann, D., Holst, Jens Juul, Schmidt, W. E., Gallwitz, B. & Nauck, M. A., 2003, In: Am. J. Physiol.. 16, p. E621-E625

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia

    Meier, J. J., Gallwitz, N., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., 2003, In: Diabetologia. 46, p. 798-801

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.

    Ugleholdt, Randi Kjærsgaard, Zhu, X., Deacon, Carolyn F., Ørskov, Cathrine, Steiner, D. F. & Holst, Jens Juul, 2003, In: Endocrinology. 145, 3, p. 1349-55 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Implementation of GLP-1 based therapy of type 2 diabetes mellitus using DPP-IV inhibitors.

    Holst, Jens Juul, 2003, In: Advances in Experimental Medicine and Biology. 524, p. 263-79 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Incretin secretion in relation to meal size and body weight in healthy subjects and in people with type 1 and type 2 diabetes mellitus

    Vilsbøll, T., Krarup, T., Sonne, J., Madsbad, S., Vølund, A., Juul, A. G. & Holst, Jens Juul, 2003, In: J. Clin. Endocrinol. Metab.. 88, p. 2706-2713

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Insulin secretion and cellular glucose metabolism after prolonged low-grade intralipid infusion in young men

    Jensen, C. B., Storgaard, H., Holst, Jens Juul, Dela, F., Madsbad, Sten & Vaag, A. A., 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 6, p. 2775-2783 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development

    Petersen, Y. M., Hartmann, B., Holst, Jens Juul, Le Huërou-Luron, I., Bjørnvad, Charlotte Reinhard & Sangild, Per Torp, 2003, In: Journal of Nutrition. 133, 6, p. 1781-1786 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Lower blood glucose, hyperglucagonemia and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice

    Gelling, R. W., Du, X. Q., Dichmann, D. S., Rømer, J., Huan, H., Cui, L., Tang, B. L., Holst, Jens Juul, Fledelius, C., Johansen, P. B., Jelicks, L. A., Serup, P., Nishimura, E. & Charron, M. J., 2003, In: Proc Natl Sci. 100, p. 1438-1443

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Lower glucose-dependent insulinotropic polypeptide (GIP) response but similar glucagon-like peptide 1 (GLP-1), glycaemic, and insulinaemic response to ancient wheat compared to modern wheat depends on processing

    Bakhøj, S., Flint, A., Holst, Jens Juul & Tetens, Inge , 2003, In: European Journal of Clinical Nutrition. 57, 10, p. 1254-1261 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Meals with similar energy densities but rich in protein, fat, carbohydrate, or alcohol have different effects on energy expenditure and substrate metabolism but not on appetite and energy intake

    Raben, A. B., Agerholm-Larsen, L., Flint, A., Holst, Jens Juul & Astrup, A., 2003, In: American Journal of Clinical Nutrition. 77, 1, p. 91-100 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    NO has tonic inhibitory, but is not involved in the vagal control or VIP effects on motility of the porcine antrum

    Schmidt, P. T., Ørskov, C., Rasmussen, T. N. & Holst, Jens Juul, 2003, In: Scandinavian Journal of Gastroenterology. 38, p. 955-961

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both involved in regulating the metabolic stability of glucagon-like peptide-1 in vivo.

    Plamboeck, A., Holst, Jens Juul, Carr, R. D. & Deacon, Carolyn F., 2003, In: Advances in Experimental Medicine and Biology. 524, p. 303-12 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    No effect of physiological concentrations of glucagon-like peptide-2 on appetite and energy intake in normal weight subjects

    Sørensen, L. B., Flint, A., Raben, A. B., Hartmann, B., Holst, Jens Juul & Astrup, A., 2003, In: International Journal of Obesity. 27, 4, p. 450-456 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    No reactive hypoglycaemia after subcutaneous administrations of GLP-1 in lean type 2 diabetic patients and in patients with diabeties secondary to chronic pancreatitis

    Knop, F., Vilsbøll, T., Larsen, S., Holst, Jens Juul & Krarup, T., 2003, In: Diabetes Care. 26, p. 2581-2587

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Normalisation of glucose concentrations and deceleration of gastric emptying of solid meals during intravenous glucagon-like peptide-1 (GLP-1) in patients with type 2 diabetes

    Meier, J. J., Gallwitz, B., Salmen, S., Goetze, O., Holst, Jens Juul & Schmidt, W. E., 2003, In: J. Clin. Endocrinol. Metab.. 88, p. 2719-2725

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety

    Schmidt, P. T., Näslund, E., Grybäck, P., Jacobsson, H., Hartmann, B., Holst, Jens Juul & Hellström, P. M., 2003, In: Regul. Pept.. 116, p. 21-25

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Prediction of glycemic index in mixed meals

    Møller, B. K., Flint, A., Pedersen, D., Raben, A. B., Tetens, I., Holst, Jens Juul & Astrup, A., 2003. 1 p.

    Research output: Contribution to conferencePaperResearch

  51. Published

    Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid small bowel resection

    Dahly, E. M., Gillingham, M. B., Guo, Z., Murali, S. G., Nelson, D. W., Holst, Jens Juul & Ney, D. M., 2003, In: Amer. J. Physiol.. 284, p. G670-G682

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Similar elimination rates of GLP-1 in obese type 2 diabetic patients and matched healthy subjects

    Vilsbøll, T., Krarup, T., Agersø, H. & Holst, Jens Juul, 2003, In: J. Clin. Endocrinol. Metab.. 88, p. 220-224

    Research output: Contribution to journalJournal articleResearchpeer-review

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