Jens Juul Holst

Jens Juul Holst

Professor


  1. 1999
  2. Published

    Proglucagon cleavage profile in canine L-cells expressing endogenous PC-1/3 and PC-2

    Damholt, A. B., Buchan, A. M. J., Holst, Jens Juul & Kofod, H., 1999, In: Endokrinologiya. 140, p. 4800-4808

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Selectivity of prandial glucose regulators: nateglinide, but not repaglinide, accelerates exocytosis in rat pancreatic A-cells

    Bokvist, K., Høy, M., Buschard, K., Holst, Jens Juul, Thomsen, M. K. & Gromada, J. L., 1999, In: Eur. J. Pharmacol.. 386, p. 105-111

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Tachykinins stimulate acid and pepsinogen secretion in the isolated perfused porcine stomach

    Schmidt, P. T., Rasmussen, T. N. & Holst, Jens Juul, 1999, In: Acta Physiologica (Print Edition). 166, p. 335-340

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Tachykinins stimulate the release of peptide hormones (glucagon-like peptide-1), and paracrine - (somatostatin) and neurotransmitters (vasoactive intestinal polypeptide) from porcine ileum through NK-1 receptors

    Schmidt, P. T., Rickelt, L. F. & Holst, Jens Juul, 1999, In: Digestive Diseases and Sciences. 44, p. 1273-1281

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The arcuate nucleus is pivotal in mediating the anorectic effects of centrally administered leptin

    Tang-Christensen, M., Holst, Jens Juul, Hartmann, B. & Vrang, N., 1999, In: NeuroReport. 10, p. 1183-1187

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The hypothalamic satiety peptide CART is expressed in anorectic and non-anorectic pancreatic islet tumors and in the normal islet of Langerhans

    Jensen, P. B., Kristensen, P., Clausen, J. T., Judge, M. E., Hastrup, S., Thim, L., Wulff, B. S., Foged, C., Jensen, J., Holst, Jens Juul & Madsen, O. D., 1999, In: FEBS Letters. 447, p. 139-143

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Treatment of Type 2 diabetes mellitus based on glucagon-like peptide-1

    Holst, Jens Juul, 1999, In: Exp. Opin. Invest. Drugs. 8, p. 1409-1415

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Glucagon-like peptide-1: a basis for new approaches to the management of diabetes

    Deacon, Carolyn F., Holst, Jens Juul & Carr, R. D., Mar 1999, In: Drugs of Today. 35, 3, p. 159-70 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Treatment of Type 2 diabetes mellitus based on glucagon-like peptide-1

    Holst, Jens Juul, Sep 1999, In: Expert Opinion on Investigational Drugs. 8, 9, p. 1409-15 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Proglucagon processing profile in canine L cells expressing endogenous prohormone convertase 1/3 and prohormone convertase 2

    Damholt, A. B., Buchan, A. M., Holst, Jens Juul & Kofod, H., Oct 1999, In: Endocrinology. 140, 10, p. 4800-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Diabetic intestinal growth adaptation and glucagon-like peptide 2 in the rat: effects of dietary fibre

    Thulesen, J., Hartmann, Bolette, Nielsen, C., Holst, Jens Juul & Poulsen, Steen Seier, Nov 1999, In: Gut. 45, 5, p. 672-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine

    Hansen, L., Deacon, Carolyn F., Ørskov, Cathrine & Holst, Jens Juul, Nov 1999, In: Molecular Endocrinology. 140, 11, p. 5356-63 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2000
  15. Published

    1,5-Anhydro fructose increase glucose tolerance by increasing GLP-1 and insulin in mice

    Ahrén, B., Holst, Jens Juul, Marcussen, J. & Yu, S., 2000, In: Eur. J. Pharmacol.. 397, p. 219-225

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Antidiabetogenic action of cholecystokinin in type 2 diabetes

    Ahrén, B., Holst, Jens Juul & Efendic, S., 2000, In: J. Clin. Endocrinol. Metab.. 85, p. 1043-8

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Circulating levels of incretin hormones an amylin in the fasting state and after oral glucose in growth hormone (GH-)deficient patients before and after GH replacement. A placebo controlled study

    Jørgensen, J. O. L., Rosenfalck, A. M., Fisker, S., Nyholm, B., Fineman, M. S., Schmitz, O., Madsbad, S., Holst, Jens Juul & Christiansen, J. S., 2000, In: European Journal of Endocrinology. 143, p. 593-599

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide

    Deacon, Carolyn F., Nauck, M. A., Meier, J., Hücking, K. & Holst, Jens Juul, 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, p. 3575-3581

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Dipeptidyl peptidase IV inhibition enhances the intestinotrophic effect of glucagon-like peptide-2 in rats and mice

    Hartmann, Bolette, Thulesen, J., Kissow, Hannelouise, Thulesen, S., Ørskov, Cathrine, Ropke, C., Poulsen, Steen Seier & Holst, Jens Juul, 2000, In: Endocrinology. 141, 11, p. 4013-20 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Effect of glucagon-like peptide 1 (7-356) amide in insulin treated patients with diabetes mellitus secondary to chronic pancreatitis

    Hedetoft, C., Larsen, S., Sheikh, S. & Holst, Jens Juul, 2000, In: Pancreas. 20, p. 25-31

    Research output: Contribution to journalJournal articleResearch

  21. Published

    Effect of glucagon-like peptide-1-(7,36)-amide on glucose effectiveness and insulin action in people with type 2 diabetes mellitus

    Vella, A., Shah, P., Basu, R., Basu, A., Holst, Jens Juul & Rizza, R. A., 2000, In: Diabetes. 49, p. 611-617

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Effects of oral glucose on systemic glucose metabolism during hyperinsulinaemic hypoglycemia in normal man

    Poulsen, P. L., Grøfte, T., Holck, P., Møller, J., Schmitz, O., Ørskov, L., Holst, Jens Juul & Møller, N., 2000, In: Metabolism. 49, p. 1598-1603

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Elevated circulating leptin in arterial hypertension: relationship to arteriovenous overflow and extraction of leptin

    Henriksen, J. H., Holst, Jens Juul, Møller, S., Jensen, G. & Bendtsen, Flemming, 2000, In: Clin.Sci.. 99, p. 527-534

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Elevated fasting glucagon-like peptide 1 and 2 secretion in ileum-resected short bowel patients with a preserved colon

    Jeppesen, P. B., Hartmann, B., Hansen, B. S., Poulsen, Steen Seier, Thulesen, J., Holst, Jens Juul & Mortensen, P. B., 2000, In: Gut. 47, p. 370-376

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Evaluation of ß-cell secretory capacity using glucagon-like peptide-1

    Visbøll, T., Toft-Nielsen, M., Krarup, T., Madsbad, S., Dinesen, B. & Holst, Jens Juul, 2000, In: Diabetes Care. 23, p. 807-812

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    GLP-2 stimulates intestinal growth by suppressing proteolysis and apoptosis in TNP-fed premature pigs

    Burrin, D. G., Stoll, B., Jiang, R., Petersen, Y., Elnif, J., Buddington, R. K., Schmidt, M., Holst, Jens Juul, Hartmann, B. & Sangild, P. T., 2000, In: Am. J. Physiol.. 279, p. G1249-G1256

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Glucose mediated glucose disposal in insulin resistant normoglycemic relatives of type 2 diabetic patients

    Henriksen, J. E., Levin, K., Thye-Rønn, P., Alford, F., Hother-Nielsen, O., Holst, Jens Juul & Beck-Nielsen, H., 2000, In: Diabetes. 49, p. 1209-1218

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Gut hormones as pharmaceuticals. From enteroglucagon to GLP-1 and GLP-2

    Holst, Jens Juul, 2000, In: Review Regul Pept. 93, p. 45-51

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Improved glucagon tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice

    Ahrén, B., Holst, Jens Juul, Mårtensson, H. & Balkan, B., 2000, In: Eur. J. Pharmacol.. 404, p. 239-245

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    In vivo and in vitro degradation of glucagon-like peptide-2 in humans

    Hartmann, B., Harr, M. B., Jeppesen, P. B., Wojdemann, M., Deacon, Carolyn F., Mortensen, P. B. & Holst, Jens Juul, 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, p. 2884-2888

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Influence of acarbose on postprandial insulin requirements in patients with type 1 diabetes

    Juntti-Berggren, L., Pigon, J., Hellström, P. M., Holst, Jens Juul & Efendic, S., 2000, In: Diab Nutr Metab. 13, p. 7-12

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: how much is enough?

    Burrin, D. G., Stoll, B., Jiang, R., Chang, X., Hartmann, B., Holst, Jens Juul, Greeley, G. H. & Reeds, P. J., 2000, In: Am. J. Clin. Nutr.. 71, p. 1603-1610

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Neurogenic nitric oxide and exocrine secretion in the gastrointestinal tract

    Ørskov, Cathrine & Holst, Jens Juul, 2000, Nitric Oxide and the Peripheral Nervous System. London, UK: Portland Press Ltd., p. 131

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  34. Published

    PACAP 1-38 as neurotransmitter in porcine adrenal glands

    Tornøe, K., Hannibal, J., Rickelt, L. F., Bolding Jensen, M., Børglum, J. T., Fahrenkrug, J. & Holst, Jens Juul, 2000, In: American Journal of Physiology: Endocrinology and Metabolism. 279, p. E1412-E1425

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    PACAP contributes to insulin secretion after gastric glucose gavage in mice

    Filipsson, K., Holst, Jens Juul & Ahrén, B., 2000, In: Am. J. Physiol.. 279, p. R424-432

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Potential targets for glucagon-like peptide 2 (GLP-2) in the rat: distribution and binding of i.v. injected (125)I-GLP-2

    Thulesen, J., Hartmann, B., Ørskov, Cathrine, Jeppesen, P. B., Holst, Jens Juul & Poulsen, Steen Seier, 2000, In: Peptides. 10, p. 1511-1517

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Regulatory peptides of the gastrointestinal tract

    Holst, Jens Juul, 2000, Small Bowel Disorders. London: Small Bowel Disorders, p. 96-115

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  38. Published

    Short-term treatment with GLP-1 increases pulsatile secretion in type 2 diabetes with no effect on orderliness.

    Juhl, C. B., Schmitz, O., Holst, Jens Juul, Vedhuis, J. & Pørksen, N., 2000, In: Diabetologia. 43, p. 583-588

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Somastostatin restrains the secretion of glucagon-like peptide-1 and 2 (GLP-1 and GLP-2) from isolated perfused porcine ileum

    Hansen, L., Hartmann, B., Bisgaard, T., Mineo, H., Jørgensen, P. N. & Holst, Jens Juul, 2000, In: Am. J. Physiol.. 278, p. E1010-E1018

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors

    Schmidt, P. T., Tornøe, K., Poulsen, Steen Seier, Nygaard, T. & Holst, Jens Juul, 2000, In: Pancreas. 20, p. 241-247

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Tachykinins in the regulation of gastric motility and secretion

    Schmidt, P. T. & Holst, Jens Juul, 2000, In: Review Cellular and Molecular Life Sciences. 57, p. 579-588

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humans

    Flint, A., Raben, A., Rehfeld, J. F., Holst, Jens Juul & Astrup, A., 2000, In: International Journal of Obesity. 24, p. 288-298

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors

    Schmidt, P. T., Tornøe, K., Poulsen, Steen Seier, Rasmussen, T. N. & Holst, Jens Juul, Apr 2000, In: Pancreas. 20, 3, p. 241-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Deficiency of the intestinal growth factor, glucagon-like peptide 2, in the colon of SCID mice with inflammatory bowel disease induced by transplantation of CD4+ T cells

    Schmidt, P. T., Hartmann, Bolette, Bregenholt, S., Holst, Jens Juul & Claesson, Mogens Helweg, 1 May 2000, In: Scandinavian Journal of Gastroenterology. 35, 5, p. 522-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon

    Jeppesen, Palle Bekker, Hartmann, Bolette, Thulesen, J., Hansen, B. S., Holst, Jens Juul, Poulsen, Steen Seier & Mortensen, P. B., Sep 2000, In: Gut. 47, 3, p. 370-6 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Potential targets for glucagon-like peptide 2 (GLP-2) in the rat: distribution and binding of i.v. injected (125)I-GLP-2

    Thulesen, J., Hartmann, Bolette, Ørskov, Cathrine, Jeppesen, Palle Bekker, Holst, Jens Juul & Poulsen, Steen Seier, Oct 2000, In: Peptides. 21, 10, p. 1511-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2001
  48. Published

    Additive glucose-lowering effects of glucagon-like peptide- 1 and metformin type 2 diabetes

    Zander, M., Taskiran, M., Toft-Nielsen, M. B. & Holst, Jens Juul, 2001, In: Diabetes Care. 24, p. 720-725

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Antidiabetogenic action of glucagon-like peptide- 1 related to administration relative to meal intake in subjects with type 2 diabetes

    Gutniak, M. K., Svartberg, J., Hellstrom, P. M. & Holst, Jens Juul, 2001, In: J Intern Med. 250, p. 81-87

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Assesment of hepatic insulin action in obese type 2 diabetic patients

    Staehr, P., Hother-Nielsen, O., Levin, K. & Holst, Jens Juul, 2001, In: Diabetes. 50, p. 1363-1370

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Attenuated processing of proglucagon and glucagon-like peptide- 1 in carboxypeptidase E-deficient mice

    Friis-Hansen, L., Lacourse, K. A., Samuelson, L. C. & Holst, Jens Juul, 2001, In: J. Endocrinol.. 169, p. 595-602

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Determinants of the effectiveness of glucagon-like peptide- 1 in type 2 diabetes

    Toft-Nielsen, M. B., Madsbad, S. & Holst, Jens Juul, 2001, In: J Clin Endocr Metab. 86, p. 3853-3860

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients

    Toft-Nielsen, M. B., Damholt, M. B., Madsbad, Sten, Hilsted, L. M., Hughes, T. E., Michelsen, B. K. & Holst, Jens Juul, 2001, In: Journal of Clinical Endocrinology and Metabolism. 86, 8, p. 3717-3723 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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