Birgitte Holst

Birgitte Holst

Guest Researcher


  1. 2011
  2. Published

    Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved

    Møller, C. L., Raun, K., Jacobsen, M. L., Pedersen, T. Å., Holst, Birgitte, Conde-Frieboes, K. W. & Wulff, B. S., 20 Jul 2011, In: Molecular and Cellular Endocrinology. 341, 1-2, p. 9-17 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism

    Petersen, P. S., Jin, C., Madsen, A. N., Rasmussen, M., Kuhre, Rune Ehrenreich, Egerod, Kristoffer Lihme, Nielsen, L. B., Schwartz, Thue W. & Holst, Birgitte, 22 Jul 2011, In: FASEB Journal. p. 3803-3814 12 p., 4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice

    Wellner, N., Tsuboi, K., Madsen, A. N., Holst, Birgitte, Diep, T. A., Nakao, M., Tokumura, A., Burns, M. P., Deutsch, D. G., Ueda, N. & Hansen, Harald S., 1 Sep 2011, In: BBA General Subjects. 1811, 9, p. 508-12 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2012
  6. Published

    Beta-Cell Specific DMT1 KO Protects Islets from Cytokine Induced ROS and Apoptosis

    Hansen, J. B., Heller, S., Madsen, A. N., Holst, Birgitte, Tonnesen, M. F. & Mandrup-Poulsen, Thomas, 2012.

    Research output: Contribution to conferencePosterResearchpeer-review

  7. Published

    Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines

    Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, Mandrup-Poulsen, Thomas, 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36

    Pedersen, S. L., Bhatia, V. K., Jurt, S., Paulsson, J. F., Pedersen, M. H., Jørgensen, R., Holst, Birgitte, Stamou, Dimitrios, Vrang, N., Zerbe, O. & Jensen, Knud Jørgen, 2012, In: Journal of Peptide Science. 18, 9, p. 579-587 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances

    Clemmensen, Christoffer, Madsen, A. N., Smajilovic, S., Holst, Birgitte & Bräuner, Hans, 2012, In: Amino Acids. 43, 3, p. 1265-1275

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity.

    Olesen, M. V., Christiansen, S. H. O., Gøtzsche, C. R., Holst, Birgitte, Kokaia, M. & Woldbye, David Paul Drucker, 2012, In: Neuropeptides (Sheffield). 46, 2, p. 71-9

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop

    Mokrosinski, J., Frimurer, Thomas Michael, Sivertsen, B., Schwartz, Thue W. & Holst, Birgitte, Sep 2012, In: Journal of Biological Chemistry. 287, p. 33488-33502 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor

    Els, S., Schild, E., Petersen, P. S., Kilian, T., Mokrosinski, J., Frimurer, Thomas Michael, Chollet, C., Schwartz, Thue W., Holst, Birgitte & Beck-Sickinger, A. G., 13 Sep 2012, In: Journal of Medicinal Chemistry. 55, 17, p. 7437-49 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Acylation type determines ghrelin's effects on energy homeostasis in rodents

    Heppner, K., Chaudhary, N., Müller, T. D., Kirchner, H., Habegger, K. M., Ottaway, N., Smiley, D. L., Dimarchi, R., Hofmann, S. M., Woods, S. C., Sivertsen, B. B., Holst, Birgitte, Pfluger, P. T., Perez-Tilve, D. & Tschöp, M. H., Oct 2012, In: Contemporary Endocrinology. 153, 10, p. 4687-95 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation

    Valentin-Hansen, L., Holst, Birgitte, Frimurer, Thomas Michael, Schwartz, Thue W. & Hansen, L. V., 21 Dec 2012, In: Journal of Biological Chemistry. 287, 52, p. 43516-43526 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2013
  16. Published

    Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice

    Clemmensen, Christoffer, Smajilovic, S., Madsen, A. N., Klein, A. B., Holst, Birgitte & Bräuner, Hans, 2013, In: Journal of Endocrinology. 217, 2, p. 151-60 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance

    Holst, Birgitte, Madsen, Kenneth Lindegaard, Jansen, A. M., Jin, C., Rickhag, Karl Mattias, Lund, Viktor Karlovich, Jensen, M., Bhatia, V., Sørensen, G., Madsen, A. N., Xue, Z., Møller, S. K., Woldbye, David Paul Drucker, Qvortrup, Klaus, Huganir, R., Stamou, Dimitrios, Kjærulff, Ole & Gether, Ulrik, Apr 2013, In: P L o S Biology (Online). 11, 4, p. 1-25 25 p., e1001542.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor

    Sivertsen, B., Holliday, N., Madsen, A. N. & Holst, Birgitte, Dec 2013, In: British Journal of Pharmacology. 170, 7, p. 1349-62 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. 2014
  20. Published

    Dietary non-esterified oleic Acid decreases the jejunal levels of anorectic N-acylethanolamines

    Diep, T. A., Madsen, A. N., Krogh-Hansen, S., Al-Shahwani, M., Al-Sabagh, L., Holst, Birgitte & Hansen, Harald S., 2014, In: PloS one. 9, 6, p. 1-7 7 p., e100365.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    New potential agents for cryopreservation of hematopoietic and adipose stromal cells

    Svalgaard, J., Haastrup, E., Brink, A., Clausen, C., Holst, Birgitte, Theilgaard-Mønch, Kim, Reckzeh, K. & Fischer-Nielsen, A., Apr 2014, In: Cytotherapy. 16, Supplement 4, p. S58

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  22. Published

    Physiological and Pathological Impact of Blood Sampling by Retro-Bulbar Sinus Puncture and Facial Vein Phlebotomy in Laboratory Mice

    Teilmann, A. C., Nygaard Madsen, A., Holst, Birgitte, Hau, Jann, Rozell, B. & Abelson, Klas, 26 Nov 2014, In: PloS one. 9, 11, p. 1-19 19 p., e113225.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo

    Panaro, B. L., Tough, I. R., Engelstoft, M. S., Matthews, R. T., Digby, G. J., Møller, C. L., Svendsen, B., Gribble, F., Reimann, F., Holst, Jens Juul, Holst, Birgitte, Schwartz, Thue W., Cox, H. M. & Cone, R. D., 2 Dec 2014, In: Cell Metabolism. 20, 6, p. 1018-29 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2015
  25. Published

    GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampus

    Młyniec, K., Budziszewska, B., Holst, Birgitte, Ostachowicz, B. & Nowak, G., 2015, In: International Journal of Neuropsychopharmacology. 18, 3, p. 1-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

    Pedersen, M. H., Bentsen, M. A., Husted, Anna Sofie, Ekberg, J. P., Wright, M. J., Di Salvo, J., Weinglass, A. B., Engelstoft, M. S., Madsen, A. N., Lückmann, Michael, Miller, M. W., Trujillo, M. E., Frimurer, Thomas Michael, Holst, Birgitte, Howard, A. D. & Schwartz, Thue W., Jan 2015, In: Molecular Metabolism. 4, 1, p. 3-14 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    GPR39 Zn2+-sensing receptor: a new target in antidepressant development?

    Młyniec, K., Singewald, N., Holst, Birgitte & Nowak, G., 15 Mar 2015, In: Journal of Affective Disorders. 174, p. 89-100 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity

    Ratner, C., Madsen, A. N., Kristensen, L. V., Skov, Louise Julie, Pedersen, K. S., Mortensen, Ole Hartvig, Knudsen, Gitte Moos, Raun, K. & Holst, Birgitte, 8 Apr 2015, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 308, 11, p. R973-R982 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Ghrelin

    Mueller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., Casanueva, F. F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P. A., Cowley, M., Cummings, D. E., Dagher, A., Diano, S. & 37 others, Dickson, S. L., Dieguez, C., Granata, R., Grill, H. J., Grove, K., Habegger, K. M., Heppner, K., Heiman, M. L., Holsen, L., Holst, Birgitte, Inui, A., Jansson, J. O., Kirchner, H., Korbonits, M., Laferrere, B., LeRoux, C. W., Lopez, M., Morin, S., Nakazato, M., Nass, R., Perez-Tilve, D., Pfluger, P. T., Schwartz, Thue W., Seeley, R. J., Sleeman, M., Sun, Y., Sussel, L., Tong, J., Thorner, M. O., van der Lely, A. J., van der Ploeg, L. H. T., Zigman, J. M., Kojima, M., Kangawa, K., Smith, R. G., Horvath, T. & Tschoep, M. H., Jun 2015, In: Molecular Metabolism. 4, 6, p. 437-460 24 p.

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission

    Młyniec, K., Gaweł, M., Librowski, T., Reczyński, W., Bystrowska, B. & Holst, Birgitte, Jun 2015, In: Brain Research Bulletin. 115, p. 23-29 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 9886