Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes
Research output: Contribution to journal › Journal article › Research › peer-review
The cytokine interleukin 6 (IL-6) is an essential regulator of the acute phase response associated with insulin-resistant states including type 2 diabetes and obesity. Three polymorphisms at positions -597, -572, and -174 of the IL6 promoter have been reported to influence IL6 transcription. The aim of this study was to investigate whether the IL6 promoter polymorphisms were associated with features of the WHO-defined metabolic syndrome and related quantitative traits in 7,553 Caucasian Danes.
| Original language | English |
|---|---|
| Journal | Diabetologia |
| Volume | 48 |
| Issue number | 2 |
| Pages (from-to) | 251-60 |
| Number of pages | 10 |
| ISSN | 0012-186X |
| DOIs | |
| Publication status | Published - 1 Feb 2005 |
- Base Sequence, Cohort Studies, DNA Primers, Denmark, European Continental Ancestry Group, Female, Gene Frequency, Genetic Variation, Genotype, Humans, Interleukin-6, Male, Metabolic Syndrome X, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Promoter Regions, Genetic
Research areas
ID: 33902487