The level of claudin-7 is reduced as an early event in colorectal carcinogenesis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The level of claudin-7 is reduced as an early event in colorectal carcinogenesis. / Lange, Jette Bornholdt; Friis, Stine; Godiksen, Sine; Poulsen, Steen S; Santoni-Rugiu, Eric; Bisgaard, Hanne C; Lothe, Inger M B; Ikdahl, Tone; Tveit, Kjell M; Johnson, Egil; Kure, Elin H; Vogel, Lotte K.

In: B M C Cancer, Vol. 11, 2011, p. 65.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lange, JB, Friis, S, Godiksen, S, Poulsen, SS, Santoni-Rugiu, E, Bisgaard, HC, Lothe, IMB, Ikdahl, T, Tveit, KM, Johnson, E, Kure, EH & Vogel, LK 2011, 'The level of claudin-7 is reduced as an early event in colorectal carcinogenesis', B M C Cancer, vol. 11, pp. 65. https://doi.org/10.1186/1471-2407-11-65

APA

Lange, J. B., Friis, S., Godiksen, S., Poulsen, S. S., Santoni-Rugiu, E., Bisgaard, H. C., Lothe, I. M. B., Ikdahl, T., Tveit, K. M., Johnson, E., Kure, E. H., & Vogel, L. K. (2011). The level of claudin-7 is reduced as an early event in colorectal carcinogenesis. B M C Cancer, 11, 65. https://doi.org/10.1186/1471-2407-11-65

Vancouver

Lange JB, Friis S, Godiksen S, Poulsen SS, Santoni-Rugiu E, Bisgaard HC et al. The level of claudin-7 is reduced as an early event in colorectal carcinogenesis. B M C Cancer. 2011;11:65. https://doi.org/10.1186/1471-2407-11-65

Author

Lange, Jette Bornholdt ; Friis, Stine ; Godiksen, Sine ; Poulsen, Steen S ; Santoni-Rugiu, Eric ; Bisgaard, Hanne C ; Lothe, Inger M B ; Ikdahl, Tone ; Tveit, Kjell M ; Johnson, Egil ; Kure, Elin H ; Vogel, Lotte K. / The level of claudin-7 is reduced as an early event in colorectal carcinogenesis. In: B M C Cancer. 2011 ; Vol. 11. pp. 65.

Bibtex

@article{e0c331b07dec4efb8c365bf7364c2d34,
title = "The level of claudin-7 is reduced as an early event in colorectal carcinogenesis",
abstract = "Compromised epithelial barriers are found in dysplastic tissue of the gastrointestinal tract. Claudins are transmembrane proteins important for tight junctions. Claudins regulate the paracellular transport and are crucial for maintaining a functional epithelial barrier. Down-regulation of the oncogenic serine protease, matriptase, induces leakiness in epithelial barriers both in vivo and in vitro. We found in an in-silico search tight co-regulation between matriptase and claudin-7 expression. We have previously shown that the matriptase expression level decreases during colorectal carcinogenesis. In the present study we investigated whether claudin-7 expression is likewise decreased during colorectal carcinogenesis, thereby causing or contributing to the compromised epithelial leakiness of dysplastic tissue.",
author = "Lange, {Jette Bornholdt} and Stine Friis and Sine Godiksen and Poulsen, {Steen S} and Eric Santoni-Rugiu and Bisgaard, {Hanne C} and Lothe, {Inger M B} and Tone Ikdahl and Tveit, {Kjell M} and Egil Johnson and Kure, {Elin H} and Vogel, {Lotte K}",
year = "2011",
doi = "10.1186/1471-2407-11-65",
language = "English",
volume = "11",
pages = "65",
journal = "B M C Cancer",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - The level of claudin-7 is reduced as an early event in colorectal carcinogenesis

AU - Lange, Jette Bornholdt

AU - Friis, Stine

AU - Godiksen, Sine

AU - Poulsen, Steen S

AU - Santoni-Rugiu, Eric

AU - Bisgaard, Hanne C

AU - Lothe, Inger M B

AU - Ikdahl, Tone

AU - Tveit, Kjell M

AU - Johnson, Egil

AU - Kure, Elin H

AU - Vogel, Lotte K

PY - 2011

Y1 - 2011

N2 - Compromised epithelial barriers are found in dysplastic tissue of the gastrointestinal tract. Claudins are transmembrane proteins important for tight junctions. Claudins regulate the paracellular transport and are crucial for maintaining a functional epithelial barrier. Down-regulation of the oncogenic serine protease, matriptase, induces leakiness in epithelial barriers both in vivo and in vitro. We found in an in-silico search tight co-regulation between matriptase and claudin-7 expression. We have previously shown that the matriptase expression level decreases during colorectal carcinogenesis. In the present study we investigated whether claudin-7 expression is likewise decreased during colorectal carcinogenesis, thereby causing or contributing to the compromised epithelial leakiness of dysplastic tissue.

AB - Compromised epithelial barriers are found in dysplastic tissue of the gastrointestinal tract. Claudins are transmembrane proteins important for tight junctions. Claudins regulate the paracellular transport and are crucial for maintaining a functional epithelial barrier. Down-regulation of the oncogenic serine protease, matriptase, induces leakiness in epithelial barriers both in vivo and in vitro. We found in an in-silico search tight co-regulation between matriptase and claudin-7 expression. We have previously shown that the matriptase expression level decreases during colorectal carcinogenesis. In the present study we investigated whether claudin-7 expression is likewise decreased during colorectal carcinogenesis, thereby causing or contributing to the compromised epithelial leakiness of dysplastic tissue.

U2 - 10.1186/1471-2407-11-65

DO - 10.1186/1471-2407-11-65

M3 - Journal article

C2 - 21310043

VL - 11

SP - 65

JO - B M C Cancer

JF - B M C Cancer

SN - 1471-2407

ER -

ID: 33232049