The effect of metformin treatment on volumes of free-living physical activity and sedentary behaviour: A post-hoc analysis of the PRE-D trial
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The effect of metformin treatment on volumes of free-living physical activity and sedentary behaviour : A post-hoc analysis of the PRE-D trial. / Karstoft, Kristian; Ried-larsen, Mathias; Bruhn, Lea; Pilmark, Nanna Skytt; Hansen, Katrine Bagge; Persson, Frederik; Jørgensen, Marit Eika; Blond, Martin Bæk; Færch, Kristine.
In: Journal of Sports Sciences, Vol. 41, No. 18, 2023, p. 1687-1691.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of metformin treatment on volumes of free-living physical activity and sedentary behaviour
T2 - A post-hoc analysis of the PRE-D trial
AU - Karstoft, Kristian
AU - Ried-larsen, Mathias
AU - Bruhn, Lea
AU - Pilmark, Nanna Skytt
AU - Hansen, Katrine Bagge
AU - Persson, Frederik
AU - Jørgensen, Marit Eika
AU - Blond, Martin Bæk
AU - Færch, Kristine
PY - 2023
Y1 - 2023
N2 - Perceived physical exertion is increased when exercise is performed on metformin treatment, but the clinical relevance of this is unknown. In this post hoc analysis of a randomized, controlled trial, we investigated whether metformin treatment was associated with lower levels of free-living physical activity. Ninety individuals with overweight/obesity (BMI>25 m2/kg) and HbA1c-defined prediabetes (39-47 mmol/mol) were randomized to treatment with dapagliflozin (SGLT2-inhibitor; 10 mg once daily, n=30), metformin (850 mg twice daily, n=30) or no treatment (control, n=30) for 13 weeks in a parallel-group, open-label trial. Before (baseline), during (6 weeks) and immediately after (13 weeks) cessation of treatment, a 6-day assessment of physical activity and sedentary behaviour was performed using accelerometer-based physical activity monitors. Intention-to-treat analyses revealed no within-group changes or differences in change between the groups for any measures of physical activity or sedentary behaviour at neither 6 nor 13 weeks. Short-term metformin treatment does not reduce free-living physical activity level in individuals with overweight/obesity and HbA1c-defined prediabetes.
AB - Perceived physical exertion is increased when exercise is performed on metformin treatment, but the clinical relevance of this is unknown. In this post hoc analysis of a randomized, controlled trial, we investigated whether metformin treatment was associated with lower levels of free-living physical activity. Ninety individuals with overweight/obesity (BMI>25 m2/kg) and HbA1c-defined prediabetes (39-47 mmol/mol) were randomized to treatment with dapagliflozin (SGLT2-inhibitor; 10 mg once daily, n=30), metformin (850 mg twice daily, n=30) or no treatment (control, n=30) for 13 weeks in a parallel-group, open-label trial. Before (baseline), during (6 weeks) and immediately after (13 weeks) cessation of treatment, a 6-day assessment of physical activity and sedentary behaviour was performed using accelerometer-based physical activity monitors. Intention-to-treat analyses revealed no within-group changes or differences in change between the groups for any measures of physical activity or sedentary behaviour at neither 6 nor 13 weeks. Short-term metformin treatment does not reduce free-living physical activity level in individuals with overweight/obesity and HbA1c-defined prediabetes.
U2 - 10.1080/02640414.2023.2291737
DO - 10.1080/02640414.2023.2291737
M3 - Journal article
C2 - 38053246
VL - 41
SP - 1687
EP - 1691
JO - Journal of Sports Sciences
JF - Journal of Sports Sciences
SN - 0264-0414
IS - 18
ER -
ID: 375203578