Neurotensin-like immunoreactivity after intestinal resection in the rat
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Neurotensin-like immunoreactivity after intestinal resection in the rat. / Poulsen, Steen Seier.
In: Gut, Vol. 28, No. 9, 09.1987, p. 1107-11.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Neurotensin-like immunoreactivity after intestinal resection in the rat
AU - Poulsen, Steen Seier
PY - 1987/9
Y1 - 1987/9
N2 - Neurotensin is a tridecapeptide located mainly in the distal small intestine. The present study was carried out in order to investigate the neurotensin response after proximal small intestinal resection in the rat. After resection, the median plasma concentration of neurotensin like immunoreactivity (NTLI) was unchanged compared with sham operated rats. Intragastric instillation of fat increased the plasma concentration of NTLI from 45 pmol/l (34-63) in sham operated rats to 92 pmol/l (46-121) in resected rats. No significant increase in the plasma concentration of NTLI was found after intragastric instillation of amino acids or glucose. The tissue concentration of NTLI increased significantly in the jejunum and ileum after proximal small intestinal resection, while the number of immunoreactive neurotensin cells was unchanged. This study shows that the adaptive responses in the distal small intestine after proximal small intestinal resection also involve the neurotensin producing cells.
AB - Neurotensin is a tridecapeptide located mainly in the distal small intestine. The present study was carried out in order to investigate the neurotensin response after proximal small intestinal resection in the rat. After resection, the median plasma concentration of neurotensin like immunoreactivity (NTLI) was unchanged compared with sham operated rats. Intragastric instillation of fat increased the plasma concentration of NTLI from 45 pmol/l (34-63) in sham operated rats to 92 pmol/l (46-121) in resected rats. No significant increase in the plasma concentration of NTLI was found after intragastric instillation of amino acids or glucose. The tissue concentration of NTLI increased significantly in the jejunum and ileum after proximal small intestinal resection, while the number of immunoreactive neurotensin cells was unchanged. This study shows that the adaptive responses in the distal small intestine after proximal small intestinal resection also involve the neurotensin producing cells.
KW - Animals
KW - Chromatography, Gel
KW - Hypertrophy
KW - Ileum
KW - Intestinal Mucosa
KW - Intestine, Small
KW - Jejunum
KW - Male
KW - Neuropeptides
KW - Neurotensin
KW - Rats
KW - Rats, Inbred Strains
M3 - Journal article
C2 - 3678970
VL - 28
SP - 1107
EP - 1111
JO - Gut
JF - Gut
SN - 0017-5749
IS - 9
ER -
ID: 47488614