Glucagon antagonism as a potential therapeutic target in type 2 diabetes
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Glucagon antagonism as a potential therapeutic target in type 2 diabetes. / Bagger, J I; Knop, F K; Holst, Jens Juul; Vilsbøll, T.
In: Diabetes, Obesity and Metabolism, Vol. 13, No. 11, 11.2011, p. 965-971.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Glucagon antagonism as a potential therapeutic target in type 2 diabetes
AU - Bagger, J I
AU - Knop, F K
AU - Holst, Jens Juul
AU - Vilsbøll, T
N1 - © 2011 Blackwell Publishing Ltd.
PY - 2011/11
Y1 - 2011/11
N2 - Glucagon is a hormone secreted from the alpha cells of the pancreatic islets. Through its effect on hepatic glucose production (HGP), glucagon plays a central role in the regulation of glucose homeostasis. In patients with type 2 diabetes mellitus (T2DM), abnormal regulation of glucagon secretion has been implicated in the development of fasting and postprandial hyperglycaemia. Therefore, new therapeutic agents based on antagonizing glucagon action, and hence blockade of glucagon-induced HGP, could be effective in lowering both fasting and postprandial hyperglycaemia in patients with T2DM. This review focuses on the mechanism of action, safety and efficacy of glucagon antagonists in the treatment of T2DM and discusses the challenges associated with this new potential antidiabetic treatment modality.
AB - Glucagon is a hormone secreted from the alpha cells of the pancreatic islets. Through its effect on hepatic glucose production (HGP), glucagon plays a central role in the regulation of glucose homeostasis. In patients with type 2 diabetes mellitus (T2DM), abnormal regulation of glucagon secretion has been implicated in the development of fasting and postprandial hyperglycaemia. Therefore, new therapeutic agents based on antagonizing glucagon action, and hence blockade of glucagon-induced HGP, could be effective in lowering both fasting and postprandial hyperglycaemia in patients with T2DM. This review focuses on the mechanism of action, safety and efficacy of glucagon antagonists in the treatment of T2DM and discusses the challenges associated with this new potential antidiabetic treatment modality.
KW - Biphenyl Compounds
KW - Diabetes Mellitus, Type 2
KW - Fasting
KW - Glucagon
KW - Glucagon-Secreting Cells
KW - Humans
KW - Hyperglycemia
KW - Hypoglycemic Agents
KW - Liver
KW - Receptors, Glucagon
KW - Signal Transduction
U2 - 10.1111/j.1463-1326.2011.01427.x
DO - 10.1111/j.1463-1326.2011.01427.x
M3 - Journal article
C2 - 21615669
VL - 13
SP - 965
EP - 971
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1462-8902
IS - 11
ER -
ID: 38531952