Adrenergic effects on renal secretion of epidermal growth factor in the rat

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Adrenergic effects on renal secretion of epidermal growth factor in the rat. / Poulsen, Steen Seier; Nexø, Ebba.

In: Regulatory Peptides, Vol. 11, No. 1, 05.1985, p. 17-25.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS & Nexø, E 1985, 'Adrenergic effects on renal secretion of epidermal growth factor in the rat', Regulatory Peptides, vol. 11, no. 1, pp. 17-25.

APA

Poulsen, S. S., & Nexø, E. (1985). Adrenergic effects on renal secretion of epidermal growth factor in the rat. Regulatory Peptides, 11(1), 17-25.

Vancouver

Poulsen SS, Nexø E. Adrenergic effects on renal secretion of epidermal growth factor in the rat. Regulatory Peptides. 1985 May;11(1):17-25.

Author

Poulsen, Steen Seier ; Nexø, Ebba. / Adrenergic effects on renal secretion of epidermal growth factor in the rat. In: Regulatory Peptides. 1985 ; Vol. 11, No. 1. pp. 17-25.

Bibtex

@article{5fc914a5b8de446a8f5bfe613cef4a5e,
title = "Adrenergic effects on renal secretion of epidermal growth factor in the rat",
abstract = "Urinary epidermal growth factor (EGF) has been demonstrated recently to originate from the kidneys. The present study was undertaken to investigate the adrenergic and cholinergic influence on secretion of renal EGF. beta-Adrenergic agonists increased the level of urinary EGF, while propranolol, a beta-adrenergic blocking agent, decreased basal and beta-adrenergic stimulated total output of urinary EGF. Acetylcholine and the anticholinergic agent atropine had no effect on the output of EGF in urine. Also chemical sympathectomy induced by 6-hydroxydopamine reduced the urinary output of EGF. None of the experimental groups had a median serum concentration above the detection limit of the assay. The present study shows that secretion of renal EGF is under the influence of the sympathetic nervous system and release of EGF is stimulated by activation of beta-adrenergic receptors in the kidneys.",
keywords = "Adrenergic beta-Agonists, Adrenergic beta-Antagonists, Animals, Creatinine, Drug Interactions, Epidermal Growth Factor, Juxtaglomerular Apparatus, Kidney, Male, Neurosecretion, Rats, Rats, Inbred Strains, Submandibular Gland, Sympathectomy, Chemical",
author = "Poulsen, {Steen Seier} and Ebba Nex{\o}",
year = "1985",
month = may,
language = "English",
volume = "11",
pages = "17--25",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Adrenergic effects on renal secretion of epidermal growth factor in the rat

AU - Poulsen, Steen Seier

AU - Nexø, Ebba

PY - 1985/5

Y1 - 1985/5

N2 - Urinary epidermal growth factor (EGF) has been demonstrated recently to originate from the kidneys. The present study was undertaken to investigate the adrenergic and cholinergic influence on secretion of renal EGF. beta-Adrenergic agonists increased the level of urinary EGF, while propranolol, a beta-adrenergic blocking agent, decreased basal and beta-adrenergic stimulated total output of urinary EGF. Acetylcholine and the anticholinergic agent atropine had no effect on the output of EGF in urine. Also chemical sympathectomy induced by 6-hydroxydopamine reduced the urinary output of EGF. None of the experimental groups had a median serum concentration above the detection limit of the assay. The present study shows that secretion of renal EGF is under the influence of the sympathetic nervous system and release of EGF is stimulated by activation of beta-adrenergic receptors in the kidneys.

AB - Urinary epidermal growth factor (EGF) has been demonstrated recently to originate from the kidneys. The present study was undertaken to investigate the adrenergic and cholinergic influence on secretion of renal EGF. beta-Adrenergic agonists increased the level of urinary EGF, while propranolol, a beta-adrenergic blocking agent, decreased basal and beta-adrenergic stimulated total output of urinary EGF. Acetylcholine and the anticholinergic agent atropine had no effect on the output of EGF in urine. Also chemical sympathectomy induced by 6-hydroxydopamine reduced the urinary output of EGF. None of the experimental groups had a median serum concentration above the detection limit of the assay. The present study shows that secretion of renal EGF is under the influence of the sympathetic nervous system and release of EGF is stimulated by activation of beta-adrenergic receptors in the kidneys.

KW - Adrenergic beta-Agonists

KW - Adrenergic beta-Antagonists

KW - Animals

KW - Creatinine

KW - Drug Interactions

KW - Epidermal Growth Factor

KW - Juxtaglomerular Apparatus

KW - Kidney

KW - Male

KW - Neurosecretion

KW - Rats

KW - Rats, Inbred Strains

KW - Submandibular Gland

KW - Sympathectomy, Chemical

M3 - Journal article

C2 - 2861625

VL - 11

SP - 17

EP - 25

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 1

ER -

ID: 47489039